Indiana University

This study tested whether a package of mobile phone tools could help more children finish their recommended vaccination schedules. Researchers worked with over 2,800 families in a low-resource setting, using text reminders, phone calls, and special vaccination events. The goal wa…

This study tested a one-year virtual support program for older adults with dementia and their caregivers. Nurses and social workers provided regular check-ins to address patient and caregiver needs, using standard plans for managing symptoms, stress, and medications. The main goa…

This study looked at how well different 'through-the-mouth' repair methods work for holes or tears in the esophagus (the swallowing tube). Doctors at a major hospital compared techniques like placing temporary stents (tubes) and using special sutures (stitches) delivered with a c…

This early-stage study tested whether a special virtual reality (VR) program could help people in early recovery from opioid use disorder. The VR experience was designed to help participants think more positively about their future, with the goal of reducing opioid use and increa…

This study tested whether delivering specialized early psychosis care via video calls (telehealth) works as well as standard in-clinic visits. It involved 74 young adults (ages 16-35) with recent-onset psychotic disorders. Over 12 months, researchers compared how often participan…

This study tested a new way to deliver HIV care to pregnant and new mothers in Kenya. The goal was to make care simpler and more efficient for women who are doing well on treatment, so doctors could focus more time on those who need extra help. Researchers wanted to see if this a…

This early-stage study tested whether injecting donor stem cells into the leg muscles of patients about to have a major amputation could help prevent serious wound complications after surgery. The main goal was to check if the injections were safe. Researchers also wanted to see …

This study tested the safety of a specialized, high-precision radiation treatment called stereotactic body radiation therapy (SBRT) for pancreatic cancer. It involved 36 patients whose cancer was difficult to remove with surgery or had come back after other treatments. The main g…

This large study tested a program to help nursing home residents with Alzheimer's and their families plan for future medical care. The goal was to reduce stressful and unwanted hospital visits by making sure a patient's treatment preferences are clearly known and respected by the…

This study tested whether a mental exercise called 'episodic future thinking' could help people in early alcohol recovery. Researchers had 58 participants imagine detailed, positive future events to see if it made them more likely to choose long-term rewards over immediate ones a…

This study compared two techniques for breaking up large, painful stones in the pancreatic duct of people with chronic pancreatitis. Thirty participants were randomly assigned to receive either external shock wave therapy or an internal laser procedure during an endoscopy. Resear…

This study tested a computer-based decision tool to help pediatricians more accurately diagnose and treat common childhood stomach disorders like IBS and constipation. Researchers compared clinics using the full tool (for screening and treatment advice) against those using only t…

This study looked back at medical records to see if a specific blood test (high-sensitivity troponin I) can accurately determine how severe a heart attack is. Researchers analyzed data from 312 patients who had a heart attack across several hospitals. The goal is to see if this b…

This study tested a new digital tool that scans patients' electronic health records to find older adults who might have undetected memory problems or be at risk for Alzheimer's disease. Researchers wanted to see if the tool was practical to use in primary care clinics and if send…

This study tested whether a special fluorescent dye called Cytalux could help surgeons better see prostate cancer tissue during surgery. The dye, injected before the operation, is designed to make cancer cells glow under a special near-infrared light. The goal was to see if this …

This study tested whether a simple, non-invasive eye-tracking test could help doctors diagnose autism in young children in Kenya. Researchers used a special camera to measure where and how children look at things during a brief 15-minute session. They compared these eye-tracking …

This study tested whether giving a daily zinc supplement could help prevent serious infections in young children with sickle cell anemia. One hundred children in Uganda, aged 1 to 5 years, were randomly assigned to receive either zinc or a placebo pill for six months. Researchers…

This study tested if short-term hormone treatments could protect the heart from a dangerous side effect caused by some medications. Researchers gave progesterone to older women and testosterone to older men to see if it reduced a specific heart rhythm risk triggered by a test dru…

This study tested a 12-week mindfulness program for teenagers with prediabetes or type 2 diabetes. The main goal was to see if the program was practical and acceptable for future research and clinical use. Researchers also explored whether the program might help improve physical …

This study tested whether high-intensity walking training is more effective than lower-intensity exercise at improving walking ability in people with chronic, incomplete spinal cord injury. It involved 53 participants who completed up to 30 training sessions over two months. Rese…

This study tested whether a gentle, low-intensity vibration platform could help reduce joint pain, muscle aches, and fatigue in early-stage breast cancer survivors. These symptoms are common side effects of aromatase inhibitor medications. For 12 months, 72 participants either us…

This study tested a one-year support program for Veterans diagnosed with Alzheimer's disease or traumatic brain injury and their family caregivers. The program aimed to improve the quality of life for both the Veteran and the caregiver while reducing the stress and burden felt by…

This study tested a training program to help nursing home staff provide better comfort and symptom management for residents with moderate to severe Alzheimer's disease. The program educated staff on palliative care, which focuses on relieving pain, stress, and other symptoms to i…

This study tested whether having a special conversation about personal care priorities could help people with mild memory loss or dementia. 178 patients received information before a clinic visit and could talk with a trained helper about what matters most to them. Researchers th…

This study tested whether listening to slow-tempo music could help prevent or reduce delirium in older adults who are critically ill and on a breathing machine in the ICU. Delirium is a serious state of confusion linked to longer hospital stays and future memory problems. Researc…

This study tested whether the medication buspirone helps reduce anger, irritability, and aggression in people living with traumatic brain injury (TBI). 81 adults with TBI and significant irritability were randomly assigned to receive either buspirone or a placebo pill for 91 days…

This study tested whether a breathing muscle training program could improve heart health and mood in postmenopausal women. Researchers worked with 28 women aged 50-75 to see if using a handheld breathing device for several weeks made a difference. The goal was to gather informati…

This study tested whether a new series of structured meetings between doctors, nurses, and parents could improve care for children with very serious cancer. The meetings, which used visual aids, aimed to help families and medical teams better align on treatment goals from diagnos…

This study tested whether a non-invasive sound therapy program could help reduce symptoms of PTSD and anxiety. 45 therapy clients either received the 5-hour listening program or continued their usual therapy for comparison. Researchers measured changes in symptoms, body awareness…

This study tested a new digital system for creating prosthetic sockets while the user is standing and bearing weight. It compared this new method to the traditional way of scanning a limb while sitting. The goal was to see if the new approach leads to a better-fitting, more comfo…

This study tested whether having a trained facilitator visit older adults at home to help them complete a medical preference form (called a POST or POLST form) would improve the match between the care they want and the care they actually receive. It involved 389 older adults livi…

This study aimed to understand how different parts of the brain help us sense where our limbs are and learn new movement skills. Researchers temporarily altered brain activity in healthy adults using safe, non-invasive magnetic stimulation, then measured their performance on move…

This study aimed to understand when and how the body's inflammatory chemicals change during a common cancer treatment called immune checkpoint inhibitor therapy. Researchers followed 98 adults with cancers like melanoma and lung cancer, taking their blood at specific times after …

This study collected information from 105 stroke patients to see how well a new type of guide wire works during a procedure to remove blood clots from the brain. The goal was to build a database to understand if this wire can reliably deliver the necessary tools to the clot and h…

This study tested a computer tool designed to help emergency room staff. The tool uses a statistical model to predict which adult patients are likely to have unmet social needs, like problems with housing, food, or transportation. Researchers wanted to see if giving doctors this …

This study aimed to understand how advanced, powered ankle prosthetics affect the pressure inside the socket and the health of the skin on the residual limb. Researchers measured six adults with below-knee amputations while they walked using different types of prosthetic ankles. …

This study tested a new public discussion method to improve the consent process for clinical research, especially for teens in sensitive HIV prevention studies. Researchers gathered 128 people, including teens, parents, and community members, to debate different consent models. T…

This study aimed to understand how different parts of the brain work together when we learn new hand movements. Researchers used brain scans and simple pointing tasks with healthy volunteers to see how vision and the sense of body position interact. The goal is to gather basic kn…

This study looked at how CBD oil interacts with tacrolimus, a critical anti-rejection drug for transplant recipients. Researchers tested 57 healthy volunteers and people with chronic kidney disease to see if CBD changes how the body processes the medication. The goal is to provid…

This study tested a new, high-resolution camera designed to see the tiny cells in the back of the eye (the retina) in much finer detail than standard equipment. Researchers wanted to see if this clearer view could help them better observe how certain eye diseases progress over ti…

This study aimed to understand why Black individuals are more prone to high blood pressure and heart problems from eating too much salt. Researchers compared how a single high-salt meal affected blood pressure and blood vessel function in healthy Black and White adults. They meas…

This small, early-stage study looked at whether taking vitamin C (ascorbic acid) tablets could temporarily make stomach contents more acidic in healthy young men who were taking a common acid-reducing drug. The goal was to see if this simple approach could help other important me…