Indiana University

This study tests whether a slow-release form of the hormone DHEA can improve asthma control in adults aged 18 to 50. Standard asthma steroids can lower the body's own DHEA, so supplementing it might help. The trial will compare DHEA capsules to a placebo in 30 participants, measu…

This study tests whether an eye-tracking device can help detect autism in toddlers born prematurely (before 37 weeks). Children aged 14-48 months referred for autism evaluation will use the device, and researchers will see if the eye-tracking data points to autism. The goal is to…

This early-phase study will test a new radioactive tracer called [18F]-AraG in just 5 people with advanced head and neck cancer. Participants will receive two PET/CT scans (before and during standard chemoradiotherapy) to see if the tracer's uptake matches immune cell activity an…

This pilot study will test whether breathing controlled amounts of carbon dioxide (CO2) can help doctors see blood flow in the heart using MRI, without needing standard contrast dyes. Thirty adults with known or suspected coronary artery disease will take part. The goal is to che…

This pilot study tests whether a computer-controlled device that delivers precise gas mixtures can safely help identify coronary artery disease in people without known heart problems. Eighty healthy adults aged 45 and older will breathe different gas concentrations while their vi…

This trial tests whether giving schoolchildren in Kenya an antimalarial drug every month, instead of every three months, better protects their brain function and school performance. Researchers will enroll 1,500 children aged 6 to 10 from six primary schools. Half will receive mo…

This study continues a community project in rural Kenya to prevent cervical cancer. It offers the 9-valent HPV vaccine to 2000 adolescent girls and tests self-collected swabs for high-risk HPV in adult women. Researchers will also study why some families do not participate and wh…

Researchers at Indiana University are testing whether a home-based virtual reality program can help people with mild dementia practice everyday activities like preparing food, washing dishes, or managing money. Forty participants will be randomly assigned to either VR training or…

Many people treated with aromatase inhibitors for early-stage breast cancer develop joint pain and stiffness that can make it hard to continue the therapy. This Phase II pilot study tests whether hydroxychloroquine, an anti-inflammatory drug often used for inflammatory joint cond…

Researchers at Indiana University are testing whether a food carbohydrate powder made from raw corn and potato starch can raise levels of GLP-1, a gut hormone that helps people feel full. The trial enrolls 62 adolescents aged 12 to 18 with obesity. For two months, participants dr…

This study tests two ways to deliver a group training program for caregivers of children with autism in low-resource areas. The program aims to reduce caregiver stress and improve the child's communication and behavior. About 320 caregivers of children aged 2 to 8 will take part.…

This trial tests a mobile app called Brain CareNotes Latino, paired with remote coaching, for Hispanic caregivers of people with dementia. The app helps create a care plan and tracks symptoms, while coaches offer personalized sessions. Researchers want to see if the intervention …

This study tests whether structured spiritual care from a chaplain can reduce anxiety and improve well-being for family members of ICU patients who cannot make decisions for themselves. The chaplain will meet with the family surrogate several times and stay in touch weekly. The t…

This pilot trial tests whether an AI-powered virtual assistant, called VICA, can help family caregivers of people with Alzheimer's disease. The assistant provides education, symptom monitoring, and coaching through conversation. Sixty caregiver-patient pairs will be randomly assi…

This study tests whether a new, fully immersive virtual reality walking program can help people with traumatic brain injury (TBI) improve their mobility and quality of life. Thirty participants will try two types of VR therapy: one on a treadmill with screens, and another using a…

This study tests a special device that monitors sleep without any physical contact, designed for people with Alzheimer's or related dementias living in long-term care facilities. About 100 residents will use the device for four weeks. Researchers want to see if sharing sleep data…

This study looks at whether high-intensity walking training can help people with cerebellar damage (a part of the brain that controls balance and coordination) improve their walking ability. Twenty participants will either do intense walking exercises or standard training. The go…

This study tests whether using the Replexa+ device twice daily for 3 months can improve blood flow in the lower legs and feet of veterans with peripheral artery disease (PAD) and peripheral neuropathy. Ten participants will have their blood flow measured before and after treatmen…

This study tests if a gentle electrical stimulation on the outer ear can activate the vagus nerve and reduce nausea, vomiting, and stomach discomfort in people with diabetes and gastroparesis. Sixty adults with both conditions will receive the treatment and report symptom changes…

This study tests whether a single dose of psilocybin (the active ingredient in magic mushrooms) combined with psychotherapy is safe and can reduce depression and substance use in veterans and first responders who haven't responded to standard treatments. Fifty participants will r…

Researchers are testing an AI-enabled support tool for parents and caregivers of children with autism in Indiana and western Kenya. The tool offers plain-language autism information, answers caregiver questions, supports coping, and helps families find local services, with safety…

This study aims to measure the normal flexibility (distensibility) of the esophagus in children aged 5 to 17 who are already undergoing anesthesia for a clinically indicated colonoscopy. Using a device called EndoFLIP, researchers will take quick measurements of the esophagus bef…

This study will test whether immunotherapy drugs (immune checkpoint inhibitors) change how the liver processes other medications. About 80 adults with various cancers who are starting immunotherapy will take a low-dose cocktail of 7 common drugs. Researchers will measure drug lev…

This study will collect blood samples from 100 adults with cancer who are starting immunotherapy. Researchers will analyze the samples to find patterns in immune cells and molecules that might predict how well the treatment works or if it causes side effects. The goal is to bette…

This study compares two ways of inviting people to screen for type 1 diabetes at home: a simple email or letter versus a personal phone call. Researchers want to see which method leads more people to complete and return a home screening kit. Participants are adults and children a…

This study looks at whether pregnancy complications like gestational diabetes or high blood pressure can accelerate ovarian aging. Researchers will follow 655 women over many years, tracking hormone levels and health outcomes. The goal is to understand if these complications lead…

This study looks at using simple, low-cost communication tools like picture boards and gestures for children with autism who have trouble speaking. It involves 500 children and their caregivers in rural Virginia and western Kenya. The goal is to find better ways to match each chi…

This study looks at whether using a set method for cervical ripening (preparing the cervix for labor) leads to more vaginal deliveries. About 1,158 pregnant women will be randomly assigned to receive either a balloon catheter alone or a balloon catheter plus the medication misopr…

This study looks at how being in hot or cold environments changes how hard it feels to breathe and how well you think when breathing is difficult. Fifteen healthy adults will do breathing tasks in different temperatures. The goal is to understand, not to treat or cure any conditi…

This study looks at whether changing the sound of a person's breathing can help them feel less breathless and think more clearly when breathing is hard. Researchers will have 15 healthy adults breathe through a mask that makes it harder to breathe, while playing back their breath…

This study looks at whether chemicals and other substances in a mother's body during pregnancy can help predict if her child will develop autism. Researchers will use stored urine and cord blood samples from 600 first-time mothers. The goal is to build a model that could estimate…

This study will enroll 150 pregnant individuals carrying twins to compare two ways of tracking fetal growth: the standard growth chart used for all pregnancies versus a chart designed specifically for twins. Participants will be randomly assigned to one of the two chart methods, …