Hospital For Special Surgery, New York

This program provides a finger joint implant for people who have had a previous finger joint replacement fail. It is for those with arthritis who need a revision surgery. The implant is available under a special FDA humanitarian use program.

This study tests whether adding two immune-targeting drugs (belimumab and rituximab) to standard treatment can improve skin hardening in people with early, severe scleroderma. About 30 adults will receive either the drug combo or a placebo, plus their usual medication, for one ye…

This early-phase study tests whether a new drug, ONTO1, is safe and tolerable for people with lupus nephritis or systemic lupus erythematosus (SLE). Researchers will also see if adding ONTO1 to standard lupus treatments can improve symptoms. The study enrolls 61 adults with activ…

This study tests whether a concentrated bone marrow injection (cBMA) given during revision ACL surgery can reduce knee pain and inflammation from post-traumatic osteoarthritis. About 40 adults aged 18-55 who need a second ACL repair will be randomly assigned to get cBMA or not. R…

This study tests whether applying tranexamic acid directly into the surgical wound, in addition to giving it through an IV, can reduce blood loss and the need for blood transfusions in adults undergoing long-segment spine surgery for scoliosis or degenerative joint disease. About…

This study tests whether a platelet-rich plasma (PRP) injection given soon after an ACL tear can reduce inflammation and improve knee function, with the goal of lowering the risk of post-traumatic osteoarthritis later. About 56 people with a recent ACL injury will receive either …

This study tests a new back brace designed to prevent a condition called proximal junctional kyphosis (PJK), where the spine curves abnormally above the surgical area after adult spinal deformity surgery. Researchers will enroll 84 adults aged 30-75 who are having their first spi…

This study looks at whether wearing a knee brace for 10 days after revision knee replacement surgery helps patients regain better knee movement after 3 months. About 170 adults having revision knee replacement for non-infection reasons will be split into two groups: one wears a b…

This study tests a powered knee brace called Agilik in 10 children with cerebral palsy who walk with a crouched posture. The brace helps straighten the knee and reduce effort while walking. Researchers will compare walking with the brace versus without it to see if it improves di…

This study tests a new device that only gives out opioid pain pills at set times after spine surgery. Half of the 30 participants will use the device, while the other half use a standard pill bottle. The goal is to see if the device helps people take fewer pills and feel safer, w…

This study tests a new pain medicine called suzetrigine in 210 adults having hip replacement surgery. Half will get the drug and half a placebo for seven days, starting before surgery. The goal is to see if it lowers the amount of opioids needed in the first 48 hours after surger…

This study tests if a continuous nerve catheter placed in the thigh provides better pain relief and reduces opioid use compared to a single nerve block after total knee replacement. About 64 adults will be randomly assigned to receive either the catheter or a sham catheter plus a…

This study tests whether a special nerve block (erector spinae plane block) can lower the amount of strong painkillers patients need after minimally invasive lower back surgery. About 48 adults having a specific type of spine fusion will be randomly assigned to receive either the…

This study compares two pain management techniques for people having total knee replacement surgery. One group gets a single injection near the knee, while the other gets a continuous pain pump through a small tube. The goal is to see which method reduces the need for opioid pain…

This study is testing a standardized physical therapy program for people aged 18-60 with non-arthritic hip and groin pain. The goal is to see if this program can improve quality of life and reduce pain. Participants will follow a set therapy plan and track their progress.

This study looks at whether bisphosphonates, drugs used to strengthen bones, can help hearing loss in people with Osteogenesis Imperfecta (OI) type I. About 100 adults and children with OI will either receive the drug or be observed for up to 5 years. The goal is to see if the tr…

This study tests if drinking a special carbohydrate drink before knee or hip replacement surgery helps patients leave the hospital sooner. About 312 adults having same-day joint replacement will be randomly assigned to get the drink or a placebo. The goal is to see if the drink r…

This study tests whether a single shot of platelet-rich plasma (PRP) can reduce pain and improve function in people with shoulder osteoarthritis. Researchers will compare low-dose PRP, high-dose PRP, and a saline placebo in 135 adults aged 18-100. The goal is to see if PRP offers…

This study tests if placing a steroid directly on the spine during back surgery helps reduce pain and the need for opioid painkillers afterward. About 150 adults having a 1-2 level lumbar laminectomy will be randomly assigned to receive the steroid or not. Researchers will track …

This study compares two nerve block methods (AFCN block vs. adductor canal block) for pain control in children aged 8-18 having ACL or MPFL knee surgery. Researchers will measure pain levels, opioid use, and muscle strength recovery. The goal is to find which block provides bette…

This study looks at whether injecting bone marrow fluid into the knee during routine arthroscopic surgery can improve pain and function. Fifty adults with cartilage or meniscus injuries will be randomly assigned to get either a bone marrow injection or a saltwater injection durin…

This study is creating a registry and repository for people with scleroderma, a rare autoimmune disease. Researchers will collect medical information and samples from 300 participants to better understand the disease's features, genetics, and biology. The goal is to lay the groun…

This study follows 850 people aged 10-35 who are having surgery to fix a kneecap that keeps popping out of place. Researchers want to learn why some patients still have kneecap problems after the operation. Participants will fill out surveys about their knee function and activity…

This study follows 432 golfers who have hip, knee, or shoulder replacement surgery. Researchers check in at 6 weeks, 3 months, 6 months, and 12 months after surgery to see if and how they return to golf. The goal is to learn more about the recovery process and what helps golfers …

This study is creating a registry of 100 people with undifferentiated connective tissue disease (UCTD) to learn more about how the condition affects them physically and emotionally. Participants will complete questionnaires about quality of life, fatigue, and mood, and doctors wi…

This study looks at whether showering early after orthopedic fracture surgery is better than waiting. About 56 adults with arm or leg fractures will be split into two groups: one showers early without covering the wound, the other follows the usual delayed approach with covered w…

This study looks at whether using artificial intelligence to simplify medical handouts helps parents better understand their child's bone condition. About 80 parents of pediatric orthopaedic patients at Hospital for Special Surgery will read either the original or an AI-simplifie…

This study looks at 20 adults with a pinched nerve in the neck (cervical radiculopathy) to see if combining advanced MRI scans with nerve tests can improve diagnosis and predict who will get better with treatment. Participants will undergo imaging and electrical studies, and thei…

This study tests whether a special thermal camera can detect changes in blood flow and nerve activity after spinal cord stimulation in people with Complex Regional Pain Syndrome (CRPS). About 12 adults with CRPS in one leg will have thermal images taken before and after the proce…

This study tests a new device called BrightPoint that uses light to help doctors confirm they have placed an epidural needle in the right spot during lumbar spine surgery. About 36 adults having spine surgery will take part. Doctors will use the device alongside the standard meth…

This study follows 250 adults who are having shoulder replacement surgery at Hospital for Special Surgery. Researchers will collect information from patients and surgeons over 1, 2, 5, and 10 years to understand how well the replacements work and what affects long-term success. N…

This study looks at how a drug called abatacept (Orencia) changes immune cells in people with rheumatoid arthritis. Researchers will compare patients starting abatacept, those on other treatments, and healthy volunteers. The goal is to understand why joints swell and hurt, and to…

This study follows 700 pregnant women with lupus or antiphospholipid syndrome to see if certain proteins in the blood can predict serious pregnancy complications like fetal death, preterm birth, or low birth weight. Participants are enrolled early in pregnancy and monitored throu…