Hackensack Meridian Health

This phase 2 trial tests whether a blood test that tracks tumor DNA can guide treatment for people with advanced non-small cell lung cancer. Participants will receive either immunotherapy alone or immunotherapy plus chemotherapy, based on their blood test results. The goal is to …

This Phase II trial is testing whether a single dose of Lu-177-PSMA-617 (Pluvicto), a radioactive drug that targets prostate cancer cells, can shrink or downstage high-risk prostate tumors before surgical removal. Fifty-four men with aggressive prostate cancer (Gleason score 8 or…

This phase 2 trial is testing a new combination of chemotherapy, radiation, and immune-suppressing drugs for people aged 18-65 with blood cancers who need a stem cell transplant. The goal is to see if this regimen improves survival one year after the transplant. About 209 partici…

This study tests a combination of three drugs—carfilzomib, iberdomide, and dexamethasone (KID)—in people newly diagnosed with multiple myeloma who are eligible for a stem cell transplant. The goal is to see if this mix is safe and improves remission rates before transplant. About…

This early-phase study tests a combination of drugs (carfilzomib, cyclophosphamide, dexamethasone, and G-CSF) to see if it can safely and effectively collect stem cells for transplant in people with multiple myeloma. The goal is to find the best dose of carfilzomib that causes th…

This study looks at whether a cardiac rehabilitation program can improve recovery for people who have had a stroke. Researchers will enroll 150 stroke survivors and add cardiac rehab to their usual care. They will measure walking ability, daily function, and whether the program r…

This study tests whether a clinic that provides extra education, tools, and follow-up calls can reduce hospital readmissions for people with a type of heart failure called HFpEF. About 150 adults discharged from Ocean University Medical Center will either receive this extra suppo…

This study tests a mistletoe extract (Iscador P) in 32 patients whose osteosarcoma has returned in the lungs and has been surgically removed. The goal is to see if the treatment can delay or prevent the cancer from coming back. Participants receive injections of the extract and a…

This study is testing whether a PSMA-PET scan using a radioactive tracer called 18F-rhPSMA-7.3 can accurately detect prostate cancer that has come back after focal gland treatment. About 70 men who had focal therapy for intermediate-risk prostate cancer will receive the scan, and…

This study tests whether taking Flomax daily for a week before chest surgery can prevent urinary retention in men aged 50 and older. Urinary retention is a common complication that can require a catheter, causing discomfort and infection risk. The goal is to see if this simple me…

This study is testing a stress management program designed for people with lung cancer who experience anxiety while waiting for routine scan results. The program includes a short orientation session, self-guided web modules with relaxation exercises, and coaching calls. Researche…

This early-phase study tests whether Tamsulosin, a drug often used for prostate issues, can help men aged 55 and older urinate normally after chest cancer surgery. About 46 participants will take the drug and be monitored for their ability to void within 6-8 hours, aiming to redu…

This study looks at whether a lower dose (15mg) of the painkiller ketorolac works as well as a higher dose (30mg) for people with kidney stone pain in the emergency room. About 86 adults under 65 with moderate to severe pain will be enrolled. The main goal is to see how much pain…

This study compares two remote training programs to see which better helps people with mild traumatic brain injury (concussion) improve their emotional health and well-being. It involves 300 adults who are at least 6 months post-injury and have trouble identifying or managing emo…

This study compares two types of talk therapy—cognitive behavioral therapy (CBT) and interpersonal therapy (IPT)—for mothers of NICU babies who have postpartum depression. It will test if a 4-week course of one therapy works better than the other, and if combining both over 8 wee…

This study looks at whether a lung ultrasound done shortly after birth can predict which late preterm babies (born 34–36 weeks) will have breathing problems in the first two days of life. Researchers will compare three different ultrasound scoring methods. The goal is to help doc…

This study aims to improve early cancer detection by collecting health information and genetic data from 10,000 adults at higher-than-average cancer risk. Participants fill out questionnaires and may provide genetic samples. No experimental treatment is given; the goal is to lear…

This study creates a worldwide registry for children diagnosed with Embryonal Tumor with Multilayer Rosettes (ETMR), a rare and aggressive brain tumor. Researchers will collect medical records, tumor tissue, and treatment outcomes from up to 100 patients of any age. The goal is t…

This study tests a new way to increase lung cancer screening in people at high risk. Researchers will use the emergency department to identify eligible patients and offer them extra help to get a low-dose CT scan. The goal is to see if this approach works better than standard car…