Gustave Roussy, Cancer Campus, Grand Paris

This study tests a drug called ASP3082 in people with advanced lung or pancreatic cancer that has a specific genetic change (KRAS G12D). About 60 participants will receive the drug intravenously once a week. The goal is to see how well it shrinks tumors and understand why some ca…

This study tests an experimental drug called patritumab deruxtecan in people with advanced breast cancer that is hormone-receptor positive but no longer responds to hormone therapy or CDK4/6 inhibitors. About 139 participants will receive the drug every three weeks to see if it s…

This study tests whether taking a daily pill called olaparib for one year after standard treatment can help prevent endometrial cancer from coming back. It is for people with a specific type of aggressive endometrial cancer (p53abn). About 554 participants will be randomly assign…

This study tests a new hormone therapy drug, elacestrant, given alone or with a drug that temporarily stops ovarian function, in premenopausal women with early-stage ER+/HER2- breast cancer. Participants take the drug for 4 weeks before their planned breast surgery. The goal is t…

This study tests whether adding local ablative treatments (like radiation or heat to destroy tumors) to standard first-line immunotherapy can help people with oligometastatic non-small cell lung cancer live longer. About 124 adults whose cancer has spread to up to 5 spots in up t…

This study tests whether two common, low-cost drugs—aspirin and atorvastatin (a cholesterol-lowering statin)—can help men with a type of advanced prostate cancer live longer. About 1,210 men whose cancer has stopped responding to hormone therapy will take one or both drugs alongs…

This study tests whether adding a drug called ATRA (a form of vitamin A) to precise radiation therapy can prevent a drop in infection-fighting white blood cells (lymphocytes) in adults with solid tumors that have spread to a few spots. About 58 participants will receive radiation…

This phase 3 trial tests whether the drug ONC201 works better than everolimus for children with diffuse intrinsic pontine glioma (DIPG), a rare and aggressive brain tumor. About 433 participants will receive one of the two drugs, and can switch if their disease gets worse. The go…

This study tests a new vaccine designed to help the immune system fight HPV-positive oropharyngeal cancer. It is for 24 adults who have completed initial treatment and show no signs of cancer remaining. The vaccine targets HPV proteins to trigger a stronger immune response, and r…

This study tests an experimental drug called tarlatamab in people with advanced small-cell lung cancer or other rare, fast-growing neuroendocrine cancers. About 40 adults will receive the drug intravenously to see if it shrinks tumors and how long that effect lasts. Researchers w…

This study looks at how older adults (70+) with advanced kidney cancer handle a combination of two drugs, cabozantinib and nivolumab. The goal is to see what doses work best and how often side effects cause treatment breaks. About 50 participants will be followed for a year to tr…

This study tests whether taking a special fecal transplant (MaaT033) alongside the immunotherapy drug cemiplimab can help overcome resistance caused by prior antibiotic use in people with advanced non-small cell lung cancer. About 162 participants will be randomly assigned to rec…

This study tests whether adding a precise, high-dose X-ray treatment (contact X-ray brachytherapy) to standard chemotherapy can help people with intermediate-stage rectal cancer keep their rectum and avoid major surgery. About 212 adults with tumors 3.1 to 6 cm in size will be en…

This study tests a drug called valemetostat in people with advanced solid tumors that have certain gene changes (like SMARCB1 or ARID1A). The drug aims to reactivate protective genes to slow or stop cancer growth. About 900 adults will take the drug daily for up to 2 years, with …

This study tests whether a near-infrared camera and a dye called indocyanine green can help surgeons spot tiny bits of cancer left behind during head and neck cancer surgery. About 65 adults with mouth or throat cancer will receive the dye before surgery, and the camera will scan…

This study tests whether low-level laser therapy can prevent severe mouth sores caused by chemotherapy in children and young adults aged 4 to 25. Participants receive laser treatment or a placebo before chemotherapy to see if it reduces the risk of painful sores. The goal is to i…

This study tests whether a digital app (Open Food Facts) plus nutrition education can help 170 people at high risk for breast, pancreas, colon cancer, or with Lynch syndrome or BRCA mutations improve their diet quality. Participants will use the app to reduce ultra-processed food…

This study tests three different online programs to help cancer patients reduce fatigue. 372 adults with cancer who feel moderate to severe tiredness will use digital tools like educational materials or a self-management program, with or without a psychologist's guidance. The goa…

This study tests whether a mobile app with educational and self-care tools can improve quality of life for people with early-stage breast cancer who are taking hormone therapy. About 180 participants will either use the app plus standard care, or standard care alone, for 12 weeks…

This study is for children and teens with cancer that has come back or not responded to standard treatments. Researchers will use advanced genetic testing of each child's tumor to select specific anticancer drugs that target the tumor's unique molecular features. The main goals a…

This study collects real-world data on innovative cancer drugs used in children, adolescents, and young adults (up to age 25) whose cancer has returned or not responded to standard therapy and who cannot join a clinical trial. Researchers will track safety and effectiveness of ta…

This study aims to create immune organoids—miniature lab-grown models of the immune system—using cells from children and young adults with brain tumors, kidney tumors, neuroblastoma, or sarcoma. Researchers will take blood or tissue samples and turn them into stem cells, then gro…

This study is testing whether simple tests on body fluids (like blood or urine) can find cancer early in people who are at high risk. About 5,900 adults with a high chance of developing cancer will provide samples and be followed for 3 years. The goal is to see which tests work b…

This study will analyze the DNA of tumors from 20,000 adults with cancer to find genetic changes that can be targeted with existing drugs or experimental treatments. The goal is to understand how many patients have a 'targetable' mutation and to use that information to guide thei…

This study aims to better understand chronic myelomonocytic leukemia (CMML) by collecting blood and bone marrow samples from 5,000 adults. Researchers will analyze these samples to improve diagnosis, predict disease progression, and identify new treatment options. Participants ar…

This study aims to find biological markers in tumor, blood, and other samples from 350 ovarian cancer patients. Researchers will track how these markers change with treatment and relate to outcomes like progression-free survival. The goal is to better understand why some cancers …

This study is for adults with any type of cancer. It looks at whether offering proactive supportive care—like help with emotional, practical, or physical needs—can reduce distress and unmet needs. Researchers will track 700 participants over 12 weeks using a simple distress therm…