European Institute Of Oncology

This study aims to see if a less invasive surgery, called targeted axillary dissection (TAD), can safely replace full axillary lymph node dissection (ALND) in women with early-stage luminal breast cancer that has spread to only 1 or 2 lymph nodes. Participants will have a marker …

This study tests a treatment called cryoablation, which uses extreme cold to freeze and destroy small, low-risk breast tumors. It aims to see if freezing the tumor works as well as surgery, while also improving quality of life, reducing pain, and avoiding general anesthesia. Abou…

This phase 2 trial tests a combination of two hormone-blocking drugs (elacestrant and exemestane) in 26 people with advanced HR+/HER2- breast cancer that has stopped responding to initial treatments. Only patients whose tumors still show high estrogen receptor activity on a speci…

This study is testing a drug called zolbetuximab combined with chemotherapy for people with advanced stomach or gastroesophageal junction cancer that has spread. The goal is to see if this combination can help control the disease longer. About 70 participants will be enrolled, an…

This study tests a combination of three drugs (atezolizumab, vinorelbine, and cyclophosphamide) in people with advanced triple-negative breast cancer that has spread. Participants must have had immunotherapy before. The goal is to see if this combo can shrink tumors and improve s…

This study aims to validate a new liquid biopsy (blood test) algorithm for detecting HRR gene mutations in patients with metastatic prostate cancer whose tumor tissue is not available or suitable for testing. The approach could help more patients access targeted therapies. Resear…

This study looks at different ways to find PIK3CA gene changes in people with metastatic breast cancer. The goal is to see which testing method works best so doctors can choose the right treatment for each patient. About 100 adults with hormone receptor-positive, HER2-negative br…

This study aims to create and validate a blood test (liquid biopsy) that can detect two important gene mutations (ESR-1 and gBRCA) in patients with a common type of advanced breast cancer (HR+/HER2-). The test is designed to help doctors choose the most effective treatments. Rese…

This study tests whether a short-term, periodic fasting-mimicking diet can safely lower high cholesterol and reduce side effects in post-menopausal women with early-stage breast cancer who are on hormone therapy (aromatase inhibitors). About 60 participants will be randomly assig…

This study aims to understand how lung cancer changes when it spreads to other parts of the body. Researchers will compare DNA from the original tumor and the metastatic site in 25 adults with non-small cell lung cancer. The goal is to learn more about cancer progression, not to …

This study examines tissue samples from people with laryngeal dysplasia, a precancerous condition of the throat, to find genetic and immune changes that may signal progression to cancer. By analyzing immune cells in the tissue, researchers hope to better predict which cases are l…

This study looks back at medical records of 34 people with rare, fast-growing neuroendocrine tumors in the lung, thymus, or pancreas. The goal is to compare how these tumors are diagnosed and treated, and to see if patients with different tumor locations have different outcomes. …

This study looks at 750 breast cancer patients whose cancer came back after they received CDK4/6 inhibitors (ribociclib or abemaciclib) along with hormone therapy. Researchers want to understand the features of these relapsed cancers and how patients fare afterward. The study doe…

This study aims to understand the mental health needs of cancer patients, their families, and healthcare providers. Researchers will gather information from 200 participants to design a digital platform called Althea. The goal is to improve emotional support and care for everyone…

This study is testing whether a new tool called HER2DX helps doctors make better treatment decisions for people with early-stage HER2+ breast cancer. About 60 participants will have their doctors use the test results during tumor board meetings. The goal is to see if the test cha…

This study surveys 200 women who had a mastectomy (breast removal) with immediate reconstruction to understand their sexual well-being. The goal is to use this information to better prepare patients before surgery and to identify those who might benefit from treatments like pelvi…

This pilot study looks at circulating tumor DNA (ctDNA) in the blood of 30 people with advanced or metastatic HER2-low breast cancer. The goal is to identify genetic mutations in the cancer, not to provide a direct treatment. The study is currently recruiting participants.

This study looks at whether emotional distress (like anxiety or depression) impacts how well first-line therapy works in people with metastatic breast cancer. Researchers will follow 1000 patients starting standard treatment and track their cancer progression over time. The goal …

This study is for people with advanced breast cancer who are about to start treatment with the drug T-DXd. The goal is to find markers in the blood that could predict serious side effects, like lung inflammation. By collecting blood samples before and during treatment, researcher…

This study is testing a new tool to predict side effects from cancer treatment in elderly patients (70+) with advanced head and neck cancer. The goal is to see if the tool can help doctors choose safer treatments and improve outcomes. About 3 participants will be enrolled to vali…

This study tests whether a type of whole-body MRI (DWB-MRI) can detect the return or spread of breast cancer earlier than standard scans. Researchers will follow 145 people with high-risk breast cancer (HER2+ or triple-negative) for 5 years to see if early detection leads to bett…

This study looks at whether a less invasive procedure called sentinel lymph node biopsy can be safely used after chemotherapy in people with inflammatory breast cancer. Normally, these patients need more extensive surgery because their cancer is advanced. The study will enroll 75…

This study reviews genetic test results from nearly 2,000 people who were referred for TP53 gene testing between 2004 and 2025. Researchers want to find out how often harmful changes in this gene occur and how they differ among various groups. The goal is to better identify and c…

This study is developing and testing a decision aid tool for women diagnosed with early-stage breast cancer. The tool is designed to help them make informed choices about their treatment. Researchers will compare how well the tool works in a group of 180 women who use it versus t…