European Institute Of Oncology

This study looks at how a highly targeted form of radiation called stereotactic radiosurgery (CyberKnife) works alongside newer treatments like immunotherapy and targeted therapy for people with melanoma that has spread to the brain. Researchers will observe 50 patients over time…

Researchers are studying whether a single-port robotic system can remove early-stage lung cancer through one small incision instead of several openings between the ribs. The approach aims to reduce pain and speed up recovery while keeping the same safety and cancer-fighting resul…

This study is for women with early-stage luminal breast cancer that has spread to 1 or 2 lymph nodes. Instead of removing many lymph nodes from the armpit, surgeons will remove only the marked suspicious node and the sentinel nodes. If fewer than 3 nodes are positive, full lymph …

This phase 2 trial is testing whether combining two hormone-blocking drugs, elacestrant and exemestane, can help people with a certain type of advanced breast cancer (HR+/HER2-) that has stopped responding to initial treatments. The study uses a special PET scan to select partici…

This study is testing a drug called zolbetuximab combined with standard chemotherapy in people with a specific type of advanced stomach cancer that has spread. The cancer must have a protein called claudin 18.2 on at least 75% of its cells and be HER2-negative. The goal is to see…

This study tests whether freezing small, low-risk breast tumors (cryoablation) is as effective as surgery. About 234 women with early-stage, hormone-sensitive breast cancer will receive cryoablation plus standard treatments like radiation. The goal is to see if this less invasive…

This study tests a combination of three drugs (atezolizumab, vinorelbine, and cyclophosphamide) in people with advanced triple-negative breast cancer that has spread. Participants have already received immunotherapy before. The goal is to see if this new mix can shrink tumors or …

This study enrolls 100 people with metastatic, hormone receptor-positive, HER2-negative breast cancer to compare different genetic testing methods for detecting PIK3CA mutations. Researchers will check how well newer DNA sequencing techniques match up with standard PCR tests. The…

This study aims to create a blood test (liquid biopsy) that can detect two key genetic mutations, ESR1 and gBRCA, in patients with a common type of metastatic breast cancer (HR+/HER2-). The test would help doctors choose the most effective treatments without needing a tissue biop…

This study is testing whether a special whole-body MRI scan can find breast cancer that has come back or spread to other parts of the body earlier than standard methods. Researchers will follow 145 women with aggressive breast cancer types (HER2+ or triple-negative) for five year…

This pilot study is testing a new, less invasive breast surgery called endoscopic video-assisted nipple-sparing mastectomy (E-NSM) for women with early-stage breast cancer or those at high risk. The goal is to see if this technique can reduce surgical trauma and improve cosmetic …

This study tests whether a special low-calorie diet that mimics fasting, taken for 5 days each month for 6 months, can lower cholesterol and reduce side effects from aromatase inhibitors in post-menopausal breast cancer patients. Sixty women on hormone therapy will be randomly as…

This study is testing a new algorithm that uses a liquid biopsy (a simple blood test) to find HRR gene mutations in patients with metastatic prostate cancer. It is for patients whose tumor tissue is not available or is inadequate for standard testing. The goal is to see if this m…

This study uses online surveys to explore whether cancer patients and their family members across the European Union have equal access to mental health screening and psychological support. Researchers will analyze responses from 2,000 participants to identify disparities, barrier…

This study investigates why some advanced or recurrent endometrial cancers respond to immunotherapy while others do not. Researchers will collect tumor samples from 510 patients before they start immunotherapy and use lab-grown tumor models to study molecular and genetic features…

This study is translating and testing an Italian version of a questionnaire that measures anxiety in cancer patients during whole-body MRI scans. Researchers will enroll 175 adult cancer patients at the European Institute of Oncology. The goal is to ensure the Italian version is …

This study looks at whether emotional distress (like anxiety or depression) affects how well first-line therapy works in people with metastatic breast cancer. Researchers will follow 1000 patients starting standard treatments based on their cancer type. The goal is to see if thos…

This study surveys 150 women aged 18-64 who follow vegetarian or vegan diets to assess their nutritional quality and adequacy. Participants will receive personalized nutritional counseling based on blood tests and food diaries. The goal is to see if counseling can improve diet, b…

This study observes 750 people with a common type of breast cancer who have already been treated with surgery and are now taking CDK4/6 inhibitors to lower the risk of cancer coming back. Researchers will track how many patients experience a relapse and how well they do over time…

This study looks at genetic and immune changes in laryngeal dysplasia, a precancerous condition of the voice box. Researchers will compare tissue samples from 3 patients to see if certain immune cells (TILs) differ between low-risk and high-risk lesions. The goal is to find marke…

This study is testing a new tool designed to predict side effects from cancer treatment in elderly patients (70+) with advanced head and neck cancer. The goal is to see if the tool can help doctors choose safer treatments. Only 3 participants are being enrolled, making this a ver…

This pilot study is looking at genetic material from tumors (circulating tumor DNA) found in the blood of 30 people with advanced or metastatic HER2-low breast cancer. The goal is to identify specific mutations in these cancers. This is an observational study, meaning no new trea…

This study looks at medical records from 34 people with advanced, well-differentiated high-grade neuroendocrine tumors in the lung, thymus, or pancreas. The goal is to see if these tumors behave differently and how they are treated. By comparing outcomes, researchers hope to find…

This study looks back at nearly 2,000 people who had genetic testing for the TP53 gene, which is linked to a high risk of many cancers. Researchers want to find out how often harmful changes in this gene occur and how they differ across groups. The goal is to improve genetic coun…

The ALTHEA study is talking to cancer patients, survivors, caregivers, and healthcare professionals to find out what mental health support they need most. Through focus groups and surveys, researchers hope to design a digital platform that addresses these unmet needs. The study i…

This study is testing whether a genetic test called HER2DX can help doctors decide on the best treatment for people with early-stage HER2-positive breast cancer. The study will enroll 60 patients and observe how often the test results change the treatment plan recommended by a te…

This study surveys 200 women who had a mastectomy (breast removal) with immediate reconstruction to understand their sexual well-being. The goal is to use this information to better prepare patients before surgery and to identify those who might benefit from specific treatments l…

This study is looking at genetic differences between the original lung cancer tumor and where it has spread in the body. Researchers will analyze DNA from stored tumor samples of 25 adults with non-small cell lung cancer. The goal is to better understand how lung cancer spreads, …

This study is for people with advanced breast cancer who are about to start treatment with the drug T-DXd. The goal is to find markers in the blood that could predict serious side effects, like lung inflammation. By collecting blood samples before and during treatment, researcher…

This study looks at whether a less invasive procedure called sentinel lymph node biopsy can be safely used after chemotherapy in people with inflammatory breast cancer. Traditionally, these patients need more extensive surgery because the cancer is advanced. The study will check …

This study is developing and testing a printed decision aid for women diagnosed with early-stage breast cancer. The tool is designed to help them make informed choices about their treatment. Researchers will compare how well women who receive the aid feel about their decisions ve…