Children's Hospital Of Philadelphia

This study tests a procedure called FETO for babies with a severe form of congenital diaphragmatic hernia (CDH), a birth defect where organs move into the chest and prevent the lungs from growing. The procedure involves placing a small balloon in the baby's windpipe while still i…

This study tests a stem cell transplant for people with blood cancers like leukemia, lymphoma, or myelodysplasia. Doctors remove certain immune cells from donor stem cells to help the body accept the transplant and reduce harmful side effects. The goal is to see if this approach …

This study tests a milder chemotherapy and immune-suppressing regimen before a bone marrow or cord blood transplant in children and young adults (ages 6 months to 25 years) with non-malignant diseases like sickle cell disease, thalassemia, and certain immune deficiencies. The goa…

This study tests the drug alpelisib (approved for breast cancer) in people aged 2 to 30 with certain genetic blood vessel growth disorders. Participants take the drug for at least 2 years and attend up to 16 clinic visits to check if their condition improves. The goal is to see i…

This pilot study tests whether adding a community health worker to the care team helps children newly diagnosed with type 1 diabetes improve blood sugar control. About 28 children under 17 with government insurance and living near Philadelphia will take part. The study tracks blo…

This study tests a stem cell transplant from a donor to treat children and young adults with life-threatening immune system problems. The goal is to replace the faulty immune system with a healthy one from the donor. Participants receive chemotherapy before the transplant to prep…

This study tests whether trametinib, a drug already approved for melanoma, can help people with rare blood vessel growth problems caused by a specific genetic pathway. About 45 children and young adults (ages 2 months to 30 years) will take the drug for up to 3 years. The goal is…

This study tests a procedure called endoscopic sleeve gastroplasty (ESG) in 10 obese teenagers aged 12-17. Instead of surgery, doctors use a flexible tube to reduce stomach size, helping with weight loss. The goal is to see if it's safe and helps teens lose weight and improve hea…

This study looks at whether a special ultrasound (contrast-enhanced ultrasound) can accurately find internal organ injuries in young children (under 8) who have had a hard hit to the belly, like from a fall or car crash. The goal is to see if this ultrasound works as well as a CT…

This study tests a therapy program for mothers recovering from substance use disorders and their children (newborn to age 5). The program combines two proven therapies to strengthen the parent-child bond and improve family well-being. About 320 mother-child pairs will take part, …

This study tests whether giving both parents and teachers a set of behavioral strategies helps children with hyperactive, inattentive, or impulsive behaviors. About 100 children in grades K-5 will take part. Some families get the toolkit along with the teacher, while others only …

This pilot study is testing whether a daily 20-minute meditation practice, done for 2-4 weeks before and 2 weeks after kidney stone surgery, can reduce pain and anxiety in patients aged 12 and older. Half of the 50 participants will learn meditation, while the other half will rec…

This study tests a resilience coaching program called PRISM for teens aged 12-17 with chronic muscle or joint pain lasting at least 3 months. The goal is to see if coaching improves daily function, reduces distress, and eases pain compared to usual care. About 260 teens and a par…

This study tests whether a set of guidelines and feedback reports can help doctors prescribe antibiotics more appropriately when children are discharged from the hospital. Over 1,100 children with pneumonia, urinary tract infections, or skin infections will take part. Families wi…

This study looks at how to safely reduce the overuse of continuous pulse oximetry (a clip that measures oxygen levels) in children hospitalized with bronchiolitis who are not on extra oxygen. Over 9,000 children participated across multiple hospitals. The goal is to find the best…

This study was designed to find out what parents of children aged 8-12 with type 1 diabetes need to better manage the condition using insulin pumps and continuous glucose monitors. The goal was to use that information to create an app to support parents and improve diabetes outco…

This study looks at whether a program called HOPS (Homework, Organization, and Planning Skills) helps middle school students with ADHD or organization problems. About 240 students in grades 6-8 will take part, with school staff leading the program. Researchers want to see if the …

This study uses special MRI scans to measure how well muscles produce energy in people with mitochondrial disease. Researchers will scan the legs of 230 participants aged 7 to 75 who either have a confirmed genetic diagnosis or strong symptoms of the disease. The goal is to learn…

This study looks at whether a stomach ultrasound can accurately measure how much food or liquid is in the stomach of injured children before emergency surgery. Knowing this may help doctors choose the safest way to manage the child's airway and reduce the risk of breathing in sto…

This study looks at how well a positive parenting program called PriCARE works for foster caregivers. The program teaches ways to build strong, caring relationships with children. Researchers want to see if it helps reduce harsh parenting and increase empathy. About 60 foster par…

This study looks at whether a simple, radiation-free ultrasound of the upper airway can help doctors predict when placing a breathing tube in a baby will be difficult. Researchers will study 180 babies under 1 year old who are scheduled for surgery. The goal is to improve safety …

This study compares two approaches to reduce the number of unnecessary blood cultures in 8 pediatric intensive care units (PICUs). It involves 8 PICU clinicians and looks at whether these strategies lower blood culture rates without harming patient safety. The goal is to improve …

This study checks if certain substances in urine can tell doctors whether a child's kidney transplant is being rejected. About 445 children aged 2 to 18 who have a kidney transplant and need a biopsy will provide urine samples. The goal is to see if these urine tests are as accur…

This study looks at whether a special computer tool can help doctors better care for children aged 5 to 18 with mild traumatic brain injury (concussion). The tool predicts which kids are at risk for long-lasting symptoms and suggests early referral to specialists. Researchers wil…

This project works with doctors and clinics to reduce unnecessary antibiotic use in children with common respiratory infections like ear infections, strep throat, sinusitis, and pneumonia. The goal is to prescribe antibiotics only when needed, using the right type and shortest ef…

This study is looking at the biological and genetic reasons why some people develop food allergies and others outgrow them. Researchers will collect blood samples from up to 5,300 people, including those with food allergies, their family members, and healthy volunteers. The goal …