Children's Hospital Of Philadelphia

This study tested whether sending text message reminders to parents could increase flu vaccination rates among children. Over 228,000 kids aged 6 months to 18 years from the Children's Hospital of Philadelphia network took part. Researchers compared vaccination rates 30 days afte…

This study tested whether adding a community health worker to the care team helps children with type 1 diabetes improve blood sugar control and reduce hospital visits. 84 children with type 1 diabetes for over a year and with recent high blood sugar or hospital visits took part. …

This study tested if the drug dupilumab can help children and young adults with eosinophilic esophagitis (EoE) safely add back foods like milk, egg, soy, or wheat into their diet. EoE is a condition where certain foods cause inflammation in the esophagus, and current treatments o…

This study looked at over 9,000 children with septic shock (a life-threatening infection) to see if a balanced salt solution is better than normal saline for preventing kidney damage. The goal was to find out which fluid reduces death, need for dialysis, or lasting kidney problem…

This study looked at whether a home sleep apnea test (HSAT) is as accurate as a standard lab sleep test (PSG) for checking if children still have sleep apnea after having their tonsils removed. 62 children aged 5-12 who had tonsil surgery for sleep apnea took both tests. The goal…

This study tested a 10-week program called Protecting Families for depressed parents and their pre-teen children. The goal was to see if the program could prevent depression in the children. 42 families took part, and researchers compared the program to parent training alone, loo…

This study tested a new mobility training program for infants and toddlers (12-36 months old) with cerebral palsy. The goal was to see if the program helps improve movement and balance compared to standard care. 42 children participated, and researchers measured changes in gross …

This study tested the safety and effectiveness of elamipretide for treating vision loss in people with Friedreich ataxia (FRDA). Twenty participants with advanced symptoms received either a low or high dose of the drug. The main goal was to see if it improved how many letters the…

This study tested a behavioral sleep program called Sleep Well! for children ages 1 to 5 who have sleep problems. About 103 families from urban primary care clinics took part. The goal was to see if the program was easy to use and helpful for improving child sleep and behavior.

This study tested whether taking an NAD+ precursor (a vitamin-like supplement called NR) combined with exercise training can improve aerobic capacity (how well the body uses oxygen during activity) and blood sugar control in people with Friedreich's ataxia. 75 participants aged 1…

This study tested a computer tool designed to help pediatricians screen and treat teens for sexually transmitted infections (STIs). Researchers worked with 190 participants, including doctors, teens aged 13 and older, and their parents, to see if the tool was easy to use and help…

This study looked at how to keep mental health supports running in under-resourced city schools. Over 400 students and staff from 12 schools took part. Researchers compared two methods to sustain programs that help students with behavior and anxiety. The goal was to see which app…

This study looked at whether digital care plans and text message reminders help families of children with a known cancer predisposition syndrome. 164 families took part. The goal was to see if these tools improved knowledge and were easy to use.

This study tested a program to reduce unnecessary antibiotic prescriptions for children with respiratory infections like colds, ear infections, and sinusitis. Over 1,000 doctors and clinics took part. The goal was to see if training and feedback could help doctors follow guidelin…

This study looked at whether a program called Friend to Friend (F2F) works when run by teachers and counselors. Over 5,000 students in Philadelphia schools took part. The program included small group sessions for girls who show relational aggression (like rumor spreading or exclu…

This study measured levels of PEG 3350 (a common laxative) and its breakdown products in the blood and urine of 158 children. Some children were taking PEG 3350, and others were not. The goal was to see how much of the medicine stays in the body and if it relates to any symptoms.…

This study tested a program to help mothers after a preterm birth. The program offered extra support and care coordination. Researchers wanted to see if mothers found it helpful and if it reduced stress. 67 mothers took part in the study.

This study tested a resource package designed to help caregivers use behavioral interventions for children with hyperactive, inattentive, or impulsive behaviors. Twenty caregivers of children in grades K-5 in the Philadelphia area participated. The research team collected feedbac…

This study tested a program to help Black youth (ages 6-18) who came to the emergency room with suicidal thoughts or self-harm. The program, called STAT-ED, was adapted for Black youth and their families. It used a patient navigator to help them start and keep up with mental heal…

This study tested a remote training program for school staff in rural areas to help them deliver mental health support to children with behavior disorders. Researchers worked with 174 participants, including counselors and teachers, to see if the training was practical and effect…

This study looked at whether a short video could help parents and teens better understand genetic testing after a new cancer diagnosis. Over 350 families from a children's hospital took part. The goal was to see if the video was helpful and easy to use, not to treat the disease i…

This study looked at how children's immune systems bounce back in the year after finishing treatment for acute lymphoblastic leukemia (ALL). Researchers tracked infections and checked immunity to vaccine-preventable diseases like measles. The goal is to learn whether kids need ex…

This study followed 60 infants at high risk for cerebral palsy from birth to 18 months old. Researchers used special sensors and robots to watch how babies learn to move—from kicking to crawling to walking. The goal was to understand how motor skills develop or get delayed, not t…

This study involved 513 children with a severe lung condition called ARDS who were on breathing machines. Researchers took blood samples to look for different patterns of illness, called subtypes, that might need different treatments. The goal was not to test a new drug, but to b…

This study looked at whether whole genome sequencing (a complete scan of a person's DNA) can help doctors diagnose leukodystrophies—rare brain disorders that damage white matter—more accurately than standard methods. About 236 children with abnormal brain MRI scans but no known g…

This study tested whether automated electronic reports could help doctors prescribe antibiotics more appropriately for common infections like pneumonia, ear infections, and sore throat. Over 26,000 patients were included, and the reports compared prescribing patterns before and a…