Children's Hospital Of Philadelphia

This large, completed study aimed to find out which of two common, inexpensive IV fluids is better for treating children with septic shock. Over 9,000 children were randomly given either 'normal saline' or a 'balanced fluid' like Lactated Ringer's during their initial emergency c…

This study tested if a medication called dupilumab could help children and young adults with eosinophilic esophagitis (EoE) safely reintroduce foods that normally trigger their condition. Participants aged 6 to 25 took dupilumab for 12 weeks to control their EoE. If their conditi…

This study tested two different approaches to help under-resourced urban public schools keep their mental health support programs running effectively over time. It involved 12 schools over three years, focusing on programs for students in grades 4-8 who showed signs of behavioral…

This small pilot study tested a new set of resources designed to help parents and caregivers use proven behavioral strategies with children showing ADHD symptoms. Twenty caregivers used the resource package with their children, and researchers gathered feedback on how easy, accep…

This study tested whether automated reports from patient health records could help doctors follow best-practice guidelines when prescribing antibiotics. It involved over 26,000 patients with common infections like pneumonia, ear infections, and sore throats. The goal was to see i…

This study tested whether a proven program to reduce relational aggression (like rumor-spreading and social exclusion) in 4th and 5th grade girls could be effectively run by school staff instead of researchers. Over 5,000 students in 40 urban schools participated. Teachers and co…

This study tested whether a special support program was helpful and practical for mothers who recently had a preterm baby. The program provided care coordination and motivational coaching to help with stress, depression, follow-up doctor visits, and healthy habits. Researchers en…

This small, completed pilot study tested whether a drug called elamipretide is safe and might help control vision loss in people with advanced Friedreich ataxia (FRDA). Twenty participants with FRDA-related vision or heart problems received either a low or high dose of the drug f…

This project tested a training program for doctors to reduce unnecessary antibiotic prescriptions for common childhood infections like earaches and sore throats. Over 1,000 clinicians across different clinics were involved. The goal was to see if education and feedback could help…

This study tested whether adding a trained community health worker to a child's diabetes care team could help improve their blood sugar control. It involved 84 children with poorly controlled type 1 diabetes. The community worker provided personalized support for one year, helpin…

This study tested whether using whole genome sequencing (a complete genetic map) as a first test could provide faster and more accurate diagnoses for children with rare, inherited brain disorders called leukodystrophies. Researchers compared the new approach to the standard step-…

This study tested whether a home sleep test is as good as the standard hospital sleep study for checking on children after they've had surgery for sleep apnea. Researchers enrolled 62 children, ages 5-12, who had their tonsils and adenoids removed. They compared the results and f…

This study tested a 10-week family program designed to prevent emotional problems in children whose parents have depression. It compared a full family program (with parent training, child therapy, and shared meals) against parent training alone. The research focused on low-income…

This study aimed to see if sending text message reminders to parents could help more children get their annual flu vaccine. It involved over 228,000 children in a large pediatric care network. Researchers tested different versions of reminder texts sent to parents whose children …

This study tested a new physical therapy program called dynamic supported mobility for infants and toddlers with cerebral palsy. Researchers wanted to find the best treatment length (6 to 24 weeks) and see if this approach worked better than current standard care. They measured c…

This study tested whether a brief behavioral program called 'Sleep Well!' is practical and helpful for families with young children who have sleep problems. Researchers worked with 103 parent-child pairs from urban primary care clinics to see if the program was easy for families …

This study observed children and young adults who recently finished treatment for acute lymphoblastic leukemia (ALL) to understand how their immune systems recover. Researchers tracked infections and measured immunity to vaccine-preventable diseases like measles and chickenpox ov…

This study aimed to understand how children's bodies process PEG 3350, a common medication ingredient. Researchers measured levels of PEG 3350 components in the blood and urine of 158 children, comparing those taking the medication to those who were not. The goal was to gather ba…

This study created and tested digital care plans and text message reminders for families of children with a known genetic condition that increases cancer risk. Researchers wanted to see if these tools were helpful and easy to use, and if they improved families' understanding of r…

This study tested a new computer tool built into a hospital's electronic health record system. The tool was designed to help pediatricians screen their teenage patients for sexually transmitted infections (STIs) like chlamydia, gonorrhea, and HIV. Researchers wanted to see if doc…

This study developed and tested a remote training program for staff in rural schools. The goal was to help counselors and teachers learn to use proven mental health support strategies for students in grades 4-8 who struggle with behavior or anxiety. Researchers measured how well …

This study aimed to understand how babies at high risk for cerebral palsy learn to move during their first 18 months of life. Researchers followed 60 infants using special robots and sensors to measure their movements while crawling and learning to walk. The goal was to gather kn…

This study tested whether a short educational video could help families understand genetic testing when a child is newly diagnosed with cancer. Researchers at Children's Hospital of Philadelphia created the video to explain a common test that looks for inherited cancer risks. The…