Centre Leon Berard

This study tests cancer treatments that target specific genetic changes in tumors. It includes 455 adults with advanced solid tumors that have not responded to standard therapies. Participants receive a treatment chosen based on their tumor's molecular profile, and the study aims…

This study is for people with certain head and neck cancers (oropharynx, larynx, hypopharynx) that haven't spread past the midline. It tests two ideas: using a smaller radiation target to reduce side effects, and adding the drug ATRA to help prevent the cancer from coming back. A…

This study tests a combination of two drugs, tarlatamab and temozolomide, in teens and adults with high-grade brain tumors that have a specific marker called DLL3. The goal is to see if the combo is safe and can shrink or control the tumors. About 70 people will join, and the tre…

This study tests a software tool called myDIET that helps manage nutrition for people with stomach or esophageal junction cancer who are scheduled for surgery. The goal is to see if using the app helps patients start their follow-up chemotherapy sooner after surgery. About 60 adu…

This study tests whether the drug regorafenib, taken for up to 12 months, can help control high-grade bone sarcomas (a type of bone cancer) in patients whose tumors did not fully disappear after standard treatments. About 36 participants aged 12 and older will receive regorafenib…

This study is for people with bone sarcomas who have finished their first round of treatment. It tests whether taking the drug regorafenib for up to 12 months can help keep the cancer from returning, compared to just being watched. About 168 participants will be randomly assigned…

This study looks at whether women with a slow-growing uterine cancer called low-grade endometrial stromal sarcoma (LGESS) can safely stop taking hormone-blocking pills (aromatase inhibitors) after long-term use. About 40 women whose cancer has spread or is at high risk will be ra…

This study tests whether giving radiation therapy after surgery helps prevent high-risk skin cancer from coming back, compared to just monitoring. About 266 adults with a type of skin cancer called cutaneous squamous cell carcinoma will be randomly assigned to receive radiation o…

This study tests a proactive care program called PASCA for adults aged 18 to 70 with multiple myeloma who have had a stem cell transplant. The program involves regular check-ups and early referrals to specialists to manage complications like high blood pressure, kidney problems, …

This study tests whether adding the immunotherapy drug atezolizumab to the standard drug imatinib can better control advanced gastrointestinal stromal tumors (GIST) that have stopped responding to multiple prior treatments. About 110 adults with inoperable or metastatic GIST will…

This phase 3 study compares a new two-drug immunotherapy (botensilimab + balstilimab) against the current standard treatment (chemotherapy plus nivolumab) in people with advanced or metastatic stomach or esophageal cancer that has a specific genetic feature (MSI-H/dMMR). The goal…

This study tests whether giving personalized diet and lifestyle advice to people at high risk for colorectal cancer helps them adopt healthier habits. About 800 participants will be followed for a year to see if they improve their diet, exercise, and other behaviors linked to can…

This study tests a new program in middle and high schools to encourage HPV vaccination among 11-17 year olds. HPV is a common virus that can cause cancer, but vaccination rates in France are low. The program will be compared to standard care to see if it increases the number of t…

This study tests whether a one-year supervised physical activity program can reduce long-term fatigue in men who have had chemotherapy for metastatic testicular cancer. About 236 men will be randomly assigned to either the exercise program or standard care. The goal is to improve…

This study tests whether a one-day hospital visit with medical, psychological, and social support after finishing cancer treatment can improve quality of life for teens and young adults (ages 15-25) with solid tumors or lymphoma. 214 participants will be randomly assigned to rece…

This study looks at two ways doctors mark non-palpable breast tumors before surgery: a magnetic clip or a thin wire. The goal is to see which method is more cost-effective and works better for patients. About 772 women with early-stage breast cancer will take part, and researcher…

This study aims to describe the immune cells and bacteria in colorectal tissue from people with benign or early-stage malignant growths. Researchers will analyze tissue samples from 400 patients undergoing surgery. The goal is to better understand how the local environment change…

This study looks at how the immune system reacts to breast and ovarian cancer. Researchers will analyze tumor and blood samples from 160 women before surgery to find patterns that might predict survival. No new treatments are tested—the goal is to gather information that could gu…

This study looks at how a 13-week physical activity program influences motivation and psychological symptoms in 80 women being treated for breast cancer. Participants will fill out questionnaires about their attitudes, confidence, and mood. The goal is to understand what helps th…

This study looks at tumor samples from 300 people with exocrine pancreatic cancer to find links between the tumor's biology and how the disease behaves. Researchers will use advanced genetic sequencing to analyze tissue already collected during surgery or biopsies. The goal is to…

This study looks at how the drug venetoclax behaves in the bodies of people with acute myeloid leukemia (AML). Researchers will take extra blood samples to measure drug levels and see how they relate to treatment response. About 100 adults starting venetoclax plus azacitidine wil…

This study aims to find genetic changes in the tumors of 750 people with advanced or metastatic pancreatic cancer. By identifying these changes, doctors hope to match patients with targeted treatments that may work better for them. The study does not test a new drug but collects …