Cancer Institute And Hospital, Chinese Academy Of Medical Sciences

This early-phase study tests an inhaled mRNA vaccine called BMD006 for people with advanced lung cancer or solid tumors that have spread to the lungs. The vaccine is designed to train the immune system to attack tumor-related proteins. About 83 participants who have exhausted sta…

This study tests a drug called romiplostim N01 in children and young adults (ages 6-24) whose platelet counts drop dangerously low after chemotherapy. The goal is to see if weekly injections can safely bring platelet levels back up within three weeks. About 50 participants will r…

This study tests whether a low-dose combination of two drugs (cytarabine and thalidomide) can control Langerhans cell histiocytosis (LCH) in adults who have not received prior treatment. LCH is a rare disease where immune cells build up and damage tissues. The trial will enroll 5…

This study tests whether adding the immunotherapy drug tislelizumab after surgery can help prevent early-stage lung cancer from returning in people with high-risk features. About 108 adults with stage I non-small cell lung cancer (tumors 2–4 cm) and at least one high-risk factor …

This study tests whether combining radiation therapy with an immunotherapy drug (sintilimab) is better than a standard liver-directed treatment (TACE) at preventing liver cancer from returning after surgery. It includes 286 adults whose tumors were removed but had narrow margins …

This early-stage study tests a new drug called CREPT-618 in 13 adults with advanced liver cancer that has not responded to standard treatments. The main goal is to check the drug's safety and find the best dose. Researchers will also look at how the drug moves through the body an…

This study aims to find the best treatment before surgery for people with esophageal or stomach cancer. It compares chemotherapy, chemoradiation, targeted therapy, and immunotherapy. The goal is to improve survival and reduce side effects. About 2000 adults with stage I to IVa ca…

This study tests whether customizing radiation, surgery, and additional drug therapy based on how well the tumor responds to initial treatment can improve outcomes for women with advanced breast cancer that has spread to nearby lymph nodes. About 157 participants will receive a p…

This study is for people with biliary tract cancer who have had surgery to remove their tumor. Researchers want to see if using a special test (MiniPDX) to pick the best chemotherapy drugs can help keep the cancer from coming back. About 204 adults will take part, and the study w…

This study tests whether adding the drug sintilimab to standard chemotherapy after surgery can help prevent stage III stomach or GEJ cancer from returning. About 70 adults who have had their tumor removed will receive the combination for up to 16 cycles. The main goal is to see h…

This study tests whether giving a targeted drug (anlotinib) along with radiation therapy before surgery can safely reduce major wound complications in adults with soft tissue sarcoma of the arms, legs, or trunk. About 30 participants will receive the combination treatment, and re…

This early-phase trial tests a new treatment called Meta10-TIL for people with advanced solid tumors that have not responded to standard therapies. The treatment uses a patient's own immune cells, which are modified in the lab to better attack cancer. The main goal is to check sa…

This study tests whether combining a targeted chemo procedure (TACE) with two immunotherapy drugs (atezolizumab and bevacizumab) can eliminate or shrink liver cancer before surgery. It involves 30 adults with resectable liver cancer at high risk of coming back. The main goal is t…

This study looks at whether giving the drug tislelizumab before surgery can help people with a specific genetic type of colorectal cancer (dMMR/MSI-H). About 30 adults with stage II or III cancer will receive three doses of tislelizumab, then have surgery to remove the tumor. Res…

This study is testing a new type of radiation therapy that adapts to changes in the body during treatment. It aims to see if this approach can reduce side effects while still controlling the cancer. The trial is for people with prostate cancer that has returned after surgery, or …

This early-phase trial tests a new cell therapy called Anti-PSMA CAR NK cells in 10 people with metastatic castration-resistant prostate cancer (mCRPC). The goal is to see if the treatment is safe and can slow the cancer. Participants must have a specific marker (PSMA) on their c…

This study tests whether a combination of lenalidomide and dexamethasone can control Rosai-Dorfman disease, a rare condition where immune cells build up and cause swelling. About 40 adults who are newly diagnosed or whose disease has returned will receive the treatment. The goal …

This study tests whether adding golidocitinib to standard PD-1 inhibitor maintenance therapy can help keep extensive-stage small cell lung cancer from progressing. About 20 adults with untreated advanced disease will receive the combination after initial chemo. The goal is to see…

This study is testing a new type of PET/CT scan that uses a radioactive tracer called Al18F-octreotide to find tumors that have SSTR proteins on their surface. The goal is to see how accurate this scan is at detecting these tumors. About 400 people with suspected or confirmed SST…

This study looks at whether proteins in urine can help doctors predict how patients with advanced colorectal cancer will respond to treatment before surgery. Researchers will collect urine samples from 400 participants and use advanced technology to find protein patterns linked t…