Boston University

This study tests whether a 12-week home-based physical activity program, using a Fitbit and coaching sessions, can help people with HIV who drink heavily increase their daily steps and reduce alcohol consumption. About 222 participants will be randomly assigned to either the full…

This study tests a combination of five oral drugs (bedaquiline, delamanid, levofloxacin, linezolid, and clofazimine) for treating multidrug-resistant tuberculosis (MDR-TB). The goal is to see if a shorter, all-pill regimen can effectively cure the infection. About 271 people with…

This study tests whether a trauma-informed program called Strength at Home works better than the usual state-approved program for reducing intimate partner violence. About 800 men who are court-ordered to attend such programs, along with their partners, will take part. Researcher…

This study looks at whether noninvasive biomarkers (like those found in breath or blood) can accurately tell if a lung nodule is cancerous or benign in high-risk smokers. Researchers will follow 85 participants with lung nodules to validate these biomarkers alongside standard ima…

This study tests whether text reminders, commitment pledges, and planning prompts can help men who have sex with men stay on PrEP, a daily pill that prevents HIV. About 106 participants in South Africa will either get standard care or these extra nudges. Researchers will check if…

This study tests whether a 3D-printed titanium mesh works better than a handmade one for rebuilding jawbone before dental implants. Thirty adults needing bone grafts will be randomly assigned to one of the two methods. Researchers will measure surgery time, healing, and bone grow…

This study looks at different ways to deliver HIV treatment and care in Zambia. Researchers want to see how these models affect patient health, satisfaction, and costs. About 8,280 patients and providers at 12 health facilities are taking part. The goal is to help policymakers ma…

This study tests whether watching a virtual reality smoking cessation program during a routine dental cleaning encourages smokers to use proven quit-smoking services. About 440 cigarette smokers will be randomly assigned to either the VR program or standard care. The main goal is…

This study looks at different ways to deliver HIV treatment in Malawi to see which methods work best for patients and clinics. Researchers are surveying over 15,000 patients and providers at 12 health facilities. The goal is to help policymakers improve HIV care and make it more …

This study looks at how different models of HIV care (like community pick-up points or fast-track refills) affect patients and healthcare workers in South Africa. Researchers will survey over 15,000 people and observe clinic operations to understand what works best. The goal is t…

This study looks for early warning signs of lung cancer in people at high risk, such as smokers aged 50-79 with COPD or a family history of lung cancer. Researchers will test blood and breath samples to find biomarkers that could predict lung cancer before symptoms appear. The go…

This study looks at a program to help caregivers tell children (ages 7-18) living with HIV about their diagnosis. The goal is to see if this approach improves the children's health and medication habits. About 747 children and their caregivers in Ghana are taking part.

This study asks about 1,100 HIV patients in South Africa what services they prefer during their first six months on antiretroviral therapy. Many patients drop out of care early, so researchers want to learn how to make treatment easier to stick with. The results will help design …

This study compares a new, non-invasive imaging technique called spatial frequency domain imaging (SFDI) to the standard skin pinch test for measuring skin thickness in people with scleroderma. Researchers will follow 78 participants over up to 3 years to see if SFDI can track ch…

This study aims to uncover the genetic causes of bicuspid aortic valve disease, a common heart condition present at birth. Researchers are gathering data from over 6,400 participants aged 8 and older to understand why some people develop serious complications like aortic aneurysm…

This study aims to discover the genetic causes of bicuspid aortic valve disease, a common heart condition. Researchers will analyze DNA from 11,000 participants, including patients and their relatives. The goal is to identify genetic variants linked to the disease, which could im…

This study looks at what services and support help people with HIV stay in treatment during their first six months on antiretroviral therapy (ART). About 771 adults in Zambia will share their preferences and needs through surveys. The goal is to design better care models that red…

This study looks at 350 former college and professional football players to find ways to diagnose Chronic Traumatic Encephalopathy (CTE) while they are still alive. Currently, CTE can only be confirmed after death. Researchers will use memory tests, brain scans, and other biomark…