VENOUS THROMBOEMBOLISM

This study tests whether giving blood thinners based on each person's risk level after hip or knee replacement works better than the standard one-size-fits-all approach. About 10,000 adults having elective hip or knee replacement will be assigned to either standard treatment or a…

This study tests whether omeprazole, a common stomach acid drug, can reduce gastrointestinal bleeding in adults aged 65 and older who are taking blood thinners for a blood clot. The trial will enroll 360 participants to see if enough people are willing to join and follow the stud…

This study tests whether a low dose of colchicine, a medicine usually used for gout, can reduce the risk of post-thrombotic syndrome (PTS) after a deep vein thrombosis (DVT) in the leg. PTS can cause pain, swelling, and skin changes long after the clot resolves. The trial will en…

This study tests a new drug called SRSD107 to see if it works better than the standard blood thinner enoxaparin at preventing dangerous blood clots after knee replacement surgery. About 450 adults aged 60 to 80 will receive either SRSD107 or enoxaparin before and after surgery. T…

This study tests whether adding rosuvastatin (a cholesterol-lowering drug) to standard blood thinners can lower the risk of another blood clot in people who recently had a deep vein thrombosis or pulmonary embolism. About 2700 adults will receive either rosuvastatin or a placebo …

This study is testing two medical devices (Symphony and Prodigy) that remove blood clots from arteries, veins, or the lungs. About 750 adults will be enrolled to see if the devices are safe and work well in the short and long term. The goal is to improve blood flow and prevent se…

This study tests a drug called Kinisoquin™ to see if it can prevent dangerous blood clots in people with advanced pancreatic cancer. About 480 adults with metastatic or locally advanced pancreatic cancer who are starting chemotherapy will receive either Kinisoquin™ or a placebo. …

This study follows 82 people who receive a vena cava filter to catch blood clots and prevent them from reaching the lungs. Researchers will check for complications like filter movement or breakage over 5 years. The goal is to confirm the device works safely for long-term use.

This study tests a device that physically removes blood clots from the leg veins (ClotTriever) against standard blood thinner medication alone. About 300 people with a recent, severe deep vein thrombosis (DVT) in one leg will be randomly assigned to one of the two treatments. The…

This study compares two blood thinners—rivaroxaban (a pill) and low-molecular-weight heparin (a daily injection)—in people with leg injuries that require a cast or brace for at least two weeks. The goal is to see if the pill is as good as or better than the injection at preventin…

This study looks at a new way to decide how long people with unexplained blood clots should take blood thinners. Currently, many patients take these drugs indefinitely, which can raise the risk of serious bleeding. The researchers will use special risk scores and involve patients…

This study looks at whether giving blood-thinning medicine after keyhole varicose vein surgery can prevent dangerous blood clots in the legs or lungs. About 1 in 50 people get a clot after this procedure. The trial will involve 6,660 adults and compare those who get the medicine …

This study tests whether a computer alert can remind doctors to prescribe blood-thinning medicine for high-risk patients after they leave the hospital. About 400 adults aged 40 and older with medical conditions like heart failure or infection will take part. The goal is to preven…

This study looks at whether wearing graduated compression stockings in the hospital, on top of taking blood-thinning medication for several weeks, can further reduce the risk of dangerous blood clots after high-risk surgery. About 8,600 adults having cancer, abdominal, or orthope…

This study looks at 200 people with high-blood-pressure-related brain bleeding to find the best time to start blood thinners (heparin) to prevent dangerous clots in the legs or lungs. Participants get heparin either within 2 days (but not before 12 hours) or starting on day 3 aft…

This study tests whether a pill (apixaban) is a safe and more convenient alternative to a daily shot (enoxaparin) for preventing blood clots after head and neck cancer surgery. About 76 adults will take one of the two medicines for 10 days after surgery and complete surveys about…

This study tests whether the blood thinner apixaban can safely prevent blood clots (venous thromboembolism) in people newly diagnosed with grade 4 glioma, a serious brain cancer. About 40 adults will take apixaban while undergoing standard radiation and chemotherapy. The main goa…

This study looks at whether taking 81 mg of aspirin once a day works just as well as taking it twice a day to prevent dangerous blood clots after hip or knee replacement surgery. About 5,500 adults having joint replacement will be randomly assigned to one of the two dosing schedu…

This study watches 2,400 lung cancer patients who are getting immunotherapy (immune checkpoint inhibitors) to see how often they develop dangerous blood clots. Researchers will compare patients who get clots with those who don't, looking for clues in their health records and lab …

This study is a registry that follows adults who have an IVC filter placed or removed to prevent blood clots. Researchers will review medical records to see how patients do over time. The goal is to learn more about the long-term safety and effectiveness of these filters. No new …

This study is not testing a new drug or treatment. Instead, researchers are gathering and combining health information from 20,000 people across Europe who have had blood clots (venous thromboembolism). The goal is to create a single, large database to improve future research and…

This study checks if a tool called the Caprini score can accurately predict blood clots in people having varicose vein surgery. Researchers will follow 3,000 adults for four weeks after surgery to see who develops clots. The goal is to identify high-risk patients who would benefi…

This study is testing a computer tool that helps doctors follow the best guidelines for preventing blood clots in adults with traumatic brain injury. About 15,000 patients across 7 hospitals will take part. The goal is to see if the tool improves how often patients get the right …

This study tests a software tool that uses DNA from a blood sample to predict if a cancer patient's blood clot is likely to return after stopping blood thinners. About 259 adults who have finished 3-12 months of blood thinner therapy will be followed for 6 months. The goal is to …

This study collects health information from over 120,000 people with blood clots (venous thromboembolism) to help doctors better understand the disease and its complications. It includes groups often left out of other studies, like pregnant women and elderly patients. The goal is…

This study looks at 380 cancer patients getting chemotherapy for ovarian, lung, stomach, or pancreatic cancer. Researchers will take extra blood samples during routine chemo visits to measure clotting markers. The goal is to find out which patients are most likely to develop dang…

This study follows 825 pregnant women who need blood thinners for blood clots to see how doctors manage their medication around childbirth. The goal is to learn which strategies lead to fewer bleeding problems. No new treatments are tested; instead, researchers observe real-world…

This study tests whether a hospital-wide quality improvement program can increase the use of blood clot prevention methods (like blood thinners or compression devices) in hospitalized patients. About 5,800 adults across multiple hospitals in China will take part. The goal is to s…

This study aims to understand if COVID-19 vaccines have any impact on brain health. Researchers will use MRI scans to look at the brains of 500 healthy adults in Hong Kong, comparing scans taken before and after vaccination. The goal is to provide clear, evidence-based informatio…