Can a Plant-Based compound stop deadly clots in pancreatic cancer?
NCT ID NCT06861088
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This Phase 3 trial tests whether Kinisoquin™, a supplement-like drug made from isoquercetin plus vitamins C and B3, can prevent dangerous blood clots in 480 people with advanced pancreatic cancer. Participants receive either Kinisoquin™ or a placebo alongside their first chemotherapy. The study tracks clot events over 16 weeks to see if the drug reduces risk.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Kinisoquin™ (isoquercetin with vitamin C and vitamin B3)
- What this could lead to
- If it works, this could provide a new way to prevent life-threatening blood clots in people with advanced pancreatic cancer, potentially improving survival and quality of life.
- What could go wrong
- This is a large Phase 3 trial, but the drug may not reduce clot risk more than placebo. Side effects or interactions with chemotherapy are possible. Results may not apply to all patients.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Phase 3
Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.
- Participants
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About 480 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Dec 2025
- Expected to finish
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Oct 2029
An estimate. End dates often move.
- Lead sponsor
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A company
The lead sponsor is a pharmaceutical, biotech, or medical-device company.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: 1. Participants must have histological or cytological confirmed pancreatic adenocarcinoma malignancy that is metastatic (including recurrent with distant metastases) or locally advanced. 2. Receiving first line chemotherapy (within 45 days of first dose of study drug) Note: subjects must be either initiating first systemic cancer therapy regimen following initial diagnosis or initiating first cycle of chemotherapy for disease recurrence. 3. Minimum age 18 years. 4. Life expectancy of greater than 4 months. 5. Eastern Cooperative Oncology Group (ECOG) performance status ≤ 2. 6. Participants must have preserved organ and marrow function as defined by: * Platelet count ≥ 100,000/mcL. * Prothrombin time (PT) and partial thromboplastin time (PTT) ≤ 1.5x institutional upper limit of normal (ULN). * Total bilirubin ≤ 3x ULN without liver metastases and \< 5x ULN in presence of liver metastases. * Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) ≤ 3x ULN without liver metastases and \< 5x ULN in the presence of liver metastases * Estimated creatinine clearance (CrCl \> 30 mL/min). 7. Willingness of women of child-bearing potential and men to use adequate contraception (hormonal or barrier method of birth control; abstinence) prior to study entry and for the duration of study participation until at least 4 weeks after study completion. 8. Ability to understand and the willingness to sign a written informed consent document. Exclusion Criteria: 1. Participants with known brain metastases 2. Prior history of documented thromboembolic event within the last 12 months (excluding central line associated events whereby patients completed anticoagulation) 3. Active bleeding or high risk for bleeding (e.g. known acute gastrointestinal ulcer) 4. History of significant hemorrhage (requiring hospitalization or transfusion) outside of a surgical setting within the last 24 months 5. Familial bleeding diathesis 6. Known diagnosis of disseminated intravascular coagulation (DIC) 7. Currently receiving anticoagulant therapy 8. Current daily use of aspirin (\> 100mg daily), Clopidogrel (Plavix), cilostazol (Pletal), aspirin-dipyridamole (Aggrenox) (within 10 days) or considered to use regular use of higher doses of non-steroidal anti-inflammatory agents as determined by the treating physician (e.g. ibuprofen \> 800mg daily or equivalent) 9. Uncontrolled intercurrent illness including, but not limited to, ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements 10. Known intolerance to the active ingredient of Kinisoquin™, isoquercetin, nicotinic acid, or ascorbic acid (including known G6PD deficiency) 11. Females of child-bearing potential who are lactating, have a positive pregnancy test at Screening, or are unwilling to use acceptable contraception prior to study entry and for the duration of study participation until at least 4 weeks after study completion. 12. Participation in other clinical trials The study is open to any individual who has a metastatic or locally advanced pancreatic adenocarcinoma malignancy without discrimination based on race, religion, political affiliation, or other criteria.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
3 sites. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Beth Israel Deaconess Medical Center
RECRUITINGBoston, Massachusetts, 02215, United States
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Clavis Medical, LLC
RECRUITINGMiami Lakes, Florida, 33014, United States
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Ventura Clinical Trials
RECRUITINGVentura, California, 93003, United States
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Other studies related to the condition(s) this trial covers.
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- Can removing liver tumors alongside the whipple procedure extend life in stage IV pancreatic cancer?