UTERINE CANCER

This study tests a new drug, zanzalintinib, combined with standard chemotherapy (paclitaxel) for people with recurrent high-grade uterine or endometrial cancer. The goal is to find the best dose and see if the combination is safe and shrinks tumors. About 36 adults who have alrea…

This study tests a drug called Rina-S in people with advanced solid tumors that have spread or can't be removed by surgery. The goal is to check safety and see if the drug shrinks tumors. About 764 participants with cancers like ovarian, lung, breast, or endometrial cancer will t…

This study tests whether the drug belzutifan can shrink or slow the growth of clear cell cancers of the ovary, uterus, cervix, vagina, or vulva that have come back or not gone away. About 32 adults will receive belzutifan pills and be monitored for tumor response and side effects…

This study tests a combination of two drugs, cabozantinib and dostarlimab, in 37 women whose gynecologic carcinosarcoma has returned after at least one prior chemotherapy. The goal is to see if the combination can keep the cancer from growing for at least 6 months. Participants w…

This study tests a drug called azenosertib in 25 women whose uterine serous carcinoma has come back or not gone away. The drug blocks a protein (Wee1) that cancer cells need to grow. Researchers will check if the drug slows tumor growth and look at how it affects cancer cells in …

This study looks at whether buying over-the-counter pain relievers or digestive aids can be an early warning sign for 10 types of cancer, including pancreatic, colon, and ovarian cancer. Researchers will compare the shopping habits of 2,900 people—some recently diagnosed with can…

This study is creating a non-invasive diagnostic test to help rule out gynecological cancer in women aged 45 and older who have abnormal uterine or postmenopausal bleeding. Researchers will enroll 4,500 women to see how well the test detects cancer (sensitivity) and correctly ide…

This study is for people who have had surgery for cervical, uterine, or endometrial cancer and need radiation to the pelvis. It uses a precise type of proton radiation to see if it causes fewer bowel side effects than standard radiation. About 25 adults will take part.

This early-phase study tests whether fecal microbiota transplantation (FMT) can safely reduce diarrhea and colon inflammation caused by immune-checkpoint inhibitors in people with genitourinary and other cancers. About 40 participants will receive FMT and be monitored for side ef…

This study tests whether using MRI to guide brachytherapy (internal radiation) for gynecologic cancers like cervical or uterine cancer can better target tumors and reduce radiation to nearby organs like the bladder and rectum. About 54 adults who are already eligible for standard…

This study looks at whether alternate day fasting (eating very little every other day) before chemotherapy can help reduce side effects and improve quality of life for women with ovarian, endometrial, or uterine cancer. About 30 women who have had surgery and are about to start c…

This early-stage study explores whether combining transrectal ultrasound (TRUS) and MRI images can help doctors more accurately guide needles during brachytherapy (internal radiation) for uterine cancer. Researchers will enroll 17 adults with uterine or cervical cancer who are sc…

This study aims to learn more about the cells and molecules found in uterine washings from 50 women undergoing gynecologic surgery. Researchers will analyze these samples to better understand gynecologic conditions like cancer. The study does not provide treatment but may help im…

This study collects blood and leftover tissue samples from 9,600 adults with different types of cancer. Researchers will use these samples to develop and improve tests that detect cancer DNA in the blood, which may help monitor for cancer return or how well treatment is working. …

This study aims to collect blood samples (liquid biopsies) from 2,500 people with cancer or at high risk for cancer. The samples will be stored and used in future research to better understand how cancers grow and respond to treatment. No new treatments are being tested; the goal…