THROMBOSIS

This study looks at whether giving platelet transfusions only when platelet levels are very low is better for extremely premature babies (born at 23-26 weeks) than giving them at a higher threshold. About 2,400 infants will be enrolled within 48 hours of birth. The goal is to see…

This study tests a new imaging test (PET-CT scan) that can see blood clots in the heart arteries from outside the body. The goal is to better identify what caused a heart attack, so patients get the right treatment. Researchers will recruit 80 adults who recently had a heart atta…

This early-phase study is testing a new radioactive tracer called 64Cu-FBP8 that lights up blood clots on PET-MR scans. Researchers want to see if it can safely and accurately find clots anywhere in the body, including in the heart of people with atrial fibrillation. The study in…

This study looks at how to best prevent dangerous blood clots in people who have a leg cast or splint after an injury. Over 10,000 participants will be split into high- and low-risk groups. High-risk patients will get either tablets or injections, while low-risk patients may get …

This study is creating a large database of health information from up to 200,000 people with blood disorders like hemophilia, sickle cell disease, and thrombosis. Researchers will use this data to better understand these conditions, improve treatments, and guide public health dec…

This study follows 3,000 people with non-cancer blood disorders (like hemophilia, sickle cell disease, and clotting issues) to see how well treatments work over time and what side effects may occur. Researchers collect safety data on approved therapies to understand long-term ris…

This study aims to understand how platelets—blood cells that help with clotting—function in healthy adults. Researchers will follow 400 volunteers for up to 10 years, collecting blood samples and health information to see how factors like diet, exercise, and genetics affect plate…

This study is creating a collection of blood, urine, and stool samples from 500 adults with or at risk for heart and blood vessel diseases. Researchers will use these samples to look for biological markers that could help understand these conditions better. The goal is to support…

This study looks at whether a type of artificial intelligence (AI) can help doctors better identify complications in people with rheumatoid arthritis (RA). Researchers will use AI to suggest possible complications from patient records and see if doctors agree with and use those s…

This study observes 1,300 critically ill ICU patients to see if measuring anti-factor Xa activity (a blood thinner level) is linked to dangerous blood clots. Researchers want to understand how well current blood thinner dosing works and whether it affects bleeding, survival, and …

This study looks at why newborns with severe congenital heart disease are more likely to develop dangerous blood clots after heart surgery. Researchers will collect blood samples from 10 babies to study tiny molecules called microRNAs that control inflammation and clotting. The g…

This study is for cancer patients who have a blood clot and are taking blood thinners. These medicines can cause dangerous bleeding. Researchers want to see if a special blood test (thrombin generation assay) can predict who is at higher risk of bleeding. The study will follow 21…

This study is creating a global registry to track the safety of direct oral anticoagulants (DOACs) in people with antiphospholipid syndrome (APS) who are not at high risk for blood clots. Researchers will collect data from 500 adults over at least 6 months to monitor rates of new…

This study looks at over 12,000 people with coronary heart disease who take blood thinners. These patients face serious risks of blood clots or major bleeding. Researchers will use advanced tests on blood samples and medical images to find new markers that better predict these ri…

This study aims to better understand the role of blood clots in different types of stroke. Researchers will use a special PET scan tracer that sticks to activated platelets, the cells that form clots, to see where clots are in the body. The study will involve 120 adults who have …