SHOCK

This study tested whether penehyclidine hydrochloride, a drug that blocks certain nerve signals, can improve tiny blood vessel function in children with shock better than the standard drug atropine. The trial included 98 children aged 28 days to 18 years who still had signs of po…

This study looked at over 9,000 children with septic shock (a life-threatening infection) to see if a balanced salt solution is better than normal saline for preventing kidney damage. The goal was to find out which fluid reduces death, need for dialysis, or lasting kidney problem…

This study tested whether a special type of dialysis (high-permeability hemodialysis) could help people recover from shock after a cardiac arrest. The treatment aimed to remove inflammatory substances from the blood to improve blood pressure and reduce the need for strong medicat…

This study looked at 60 critically ill patients with acute kidney injury and shock who needed dialysis. Researchers compared a special dialysis method that adjusts salt levels (sodium profiling) to standard dialysis. The goal was to see if the special method helps keep blood pres…

This study tested whether methylene blue, a medicine that affects blood vessel tone, can prevent low blood pressure during kidney dialysis in critically ill patients. 261 adults with acute kidney injury and low blood pressure or requiring blood pressure support took part. The goa…

This study tested whether giving a pill called midodrine can help critically ill patients stop receiving intravenous norepinephrine (a blood pressure medication) sooner. The study included 112 patients who were stable but still needed low doses of norepinephrine. The goal was to …

This study tested whether using ultrasound to guide a needle into the wrist artery works better than the usual method of feeling for the pulse in emergency patients with shock. 100 adults with shock were randomly assigned to either ultrasound guidance or the traditional palpation…

This study looked at whether ultrasound measurements of the heart and blood vessels can predict which children on breathing machines will benefit from extra fluids. Only 4 children participated, so the findings are very limited. The goal was to find a better way to avoid giving u…

This study looked at 300 critically ill ICU patients who were receiving medications to support their blood pressure. The goal was to see if blood pressure readings taken at the upper arm (brachial) differ from those at the wrist (radial), and whether larger differences are linked…

This study looked at how blood flow and oxygen levels in the brain change when doctors treat very sick children for low blood pressure or shock. The researchers used ultrasound and light-based sensors to monitor the brain in 27 children in the intensive care unit. The goal was to…

This study tested a simple bedside method to predict whether infants in shock would benefit from additional fluids. Ten infants under 2 years old on breathing machines had their heart function measured before, during, and after a 15-second breathing pause. The goal was to see if …

This study looked at whether measuring the jugular vein and using shock indices can predict a dangerous drop in blood pressure after spinal anesthesia in planned C-sections. Researchers studied 60 pregnant women to see if these simple tests could help doctors catch and manage low…

This study looked at over 2,400 critically ill patients who needed breathing machines and medications for shock. Researchers compared early feeding through a tube into the stomach (enteral nutrition) versus feeding through a vein (parenteral nutrition) to see which approach reduc…

This small pilot study tested whether it is possible to set personalized blood pressure targets for critically ill patients based on their brain's oxygen levels. Researchers monitored 16 ICU patients with respiratory failure or shock for 24 hours to find each patient's optimal bl…