RHEUMATOID ARTHRITIS (RA)

This study is testing a live attenuated dengue vaccine (Butantan-DV) in people aged 12–59 with autoimmune rheumatic diseases like rheumatoid arthritis or lupus, who are stable and on low or no immune-suppressing drugs. Researchers want to see if the vaccine is safe and triggers a…

This early-stage study tests a new medicine, SAR448501/DR-0201, in adults with lupus or rheumatoid arthritis. The goal is to find safe and tolerable doses by checking side effects and how the drug works in the body. About 62 participants will receive multiple doses and be followe…

This early-phase study tests a new treatment called HBI0101 CAR T for people with severe autoimmune diseases like lupus, multiple sclerosis, and rheumatoid arthritis that haven't improved with standard treatments. The therapy uses a patient's own immune cells, modified to target …

This study is testing a new treatment for people with certain autoimmune diseases (rheumatoid arthritis, Sjögren's disease, myositis, or scleroderma) that have not responded to standard therapies. The treatment combines a natural killer cell therapy called AlloNK with the drug ri…

This early-stage study tests a new drug, CLN-978, in 37 adults with rheumatoid arthritis that hasn't responded to other treatments. The goal is to see if the drug is safe and can control the disease by lowering certain immune cells. Participants must have active arthritis and sig…

This study tests a new drug called cizutamig in 28 people with severe rheumatoid arthritis that hasn't improved with other treatments. The main goal is to check if the drug is safe and to see early signs of how well it works. Participants will receive the drug and be closely moni…

This study monitors the safety and effectiveness of peficitinib, a medication for rheumatoid arthritis (RA), in 3,000 patients receiving it for the first time in regular medical practice. Researchers will track side effects, infections, and disease activity scores to see how well…

This early-stage study tests a new drug called LY4213663 in healthy volunteers and people with rheumatoid arthritis (RA). The main goal is to see if the drug is safe and what side effects it may cause. Researchers will also measure how the body processes the drug. The study lasts…

This study tests a new oral drug, TollB-001, in 24 adults aged 18-70 with moderate to severe active rheumatoid arthritis who haven't responded well to standard treatments. Participants take the drug or a placebo daily for 4 weeks, with a 1-week follow-up. The goal is to check saf…

This study tests whether a single injection of human induced stem cells (hiSCs) into the knee is safe and can help relieve symptoms of rheumatoid arthritis. Fifteen adults with active knee arthritis will receive the injection and be monitored for side effects and improvements in …

This early-phase trial tests an experimental treatment called QEL-005 in 16 adults with two autoimmune diseases: diffuse cutaneous systemic sclerosis and difficult-to-treat rheumatoid arthritis. QEL-005 is made from a patient's own white blood cells, which are genetically modifie…

This study tests if using an ultrasound device at home is safe and practical for people with rheumatoid arthritis (RA). About 40 adults with moderate-to-severe RA will use the device daily for 8 weeks. Researchers will measure changes in inflammation (hsCRP) and joint symptoms, c…

This study looks at how well and how safely a methotrexate injection works for Chinese adults with rheumatoid arthritis (RA). It will follow 10,000 people in regular clinics, including those with additional lung or heart problems. The goal is to see if the drug helps control join…

This early-phase study tests a new drug called A-319 in 12 adults with active rheumatoid arthritis who haven't responded well to standard treatments. The main goal is to check if the drug is safe and tolerable. Researchers will also measure how the drug moves through the body and…

This early-phase study tests a new treatment called ADI-001 for people with rheumatoid arthritis that hasn't improved with standard therapies. ADI-001 uses specially engineered immune cells to target and destroy faulty B cells that drive inflammation. The study involves about 25 …

This study tests a non-invasive device worn on the ear that sends mild electrical pulses to the vagus nerve, aiming to reduce inflammation in people with moderate-to-severe rheumatoid arthritis (RA). The trial includes 128 adults whose RA has not improved with standard biologic o…

This early-phase study tests the safety of a new drug called CC312 in up to 18 adults with autoimmune diseases like lupus, arthritis, or scleroderma that haven't responded to standard treatments. CC312 works by directing the body's immune T cells to attack faulty B cells, similar…

This study tests whether a 16-week plant-based diet can reduce disease activity and improve quality of life in adults with rheumatoid arthritis (RA). Participants receive weekly food boxes, diet guidance, and a cooking class, while a control group continues their usual diet. The …

This study tests an experimental oral drug called AP1189, taken alongside methotrexate, for people recently diagnosed with rheumatoid arthritis who have not yet tried disease-modifying drugs. The goal is to see if AP1189 can better control joint inflammation and disease activity …

This study tests whether people with rheumatoid arthritis, psoriatic arthritis, or axial spondyloarthritis who are doing well on a JAK inhibitor can safely lower their dose without losing disease control. About 200 participants will either follow a guided dose-reduction plan or c…

This study is testing a non-invasive, at-home ultrasound device that stimulates the spleen to reduce inflammation in people with moderate-to-severe rheumatoid arthritis. The research involves 60 adults who haven't responded well to standard arthritis medications. Participants wil…

This study is testing a new blood test that may help doctors choose the most effective medicine for people with rheumatic diseases like rheumatoid arthritis, lupus, and vasculitis. Researchers will take a blood sample and use it to see how a person's immune cells react to differe…

This study compares two common steroid treatments for rheumatoid arthritis flares: pills taken over a few weeks versus a single injection. Researchers want to see which option provides better symptom relief, improves daily function, and is preferred by patients. The trial will in…

This study tests whether one-on-one coaching from a trained peer (someone with rheumatoid arthritis) can help reduce anxiety and depression in adults with RA. About 250 participants will meet weekly with a coach for 9 weeks and complete surveys. The goal is to see if this approac…

This early-stage study tests a new drug called F8IL10, given as an injection directly into the joint, for people with rheumatoid arthritis. The main goal is to check its safety and find the best dose. About 42 adults with active arthritis in a knee, ankle, shoulder, wrist, or elb…

This study looks at how 45, 90, or 150 minutes of physical activity each week affects arthritis symptoms like pain and mobility. Researchers will track changes in walking distance and other physical functions. The goal is to find the most effective amount of exercise for people w…

This study compares the effects of Mediterranean and Paleolithic diets on disease activity, nutrition, and quality of life in adults aged 40-60 with rheumatoid arthritis. Over 12 weeks, participants will follow one of these diets or their usual diet. The goal is to see if these e…

This early-stage study tests a new drug called KT501 in 24 adults with moderate to severe rheumatoid arthritis (RA). The main goal is to check safety and how the body processes the drug after a single injection. Participants must have had RA for at least 6 months and not responde…

This study looks at whether taking a daily probiotic for 6 weeks can help adults with rheumatoid arthritis. Fifty participants will take the probiotic and provide stool samples to track how the bacteria settle in the gut. Researchers will also check joint pain and swelling to see…

This early-stage study tests a new oral drug, LPX-TI641, in 48 adults with rheumatoid arthritis or psoriatic arthritis. The main goal is to see if the drug is safe and tolerable compared to a placebo over 28 days. Researchers will also measure how the drug moves through the body.…

This study tests whether a ketogenic (low-carb, high-fat) or carnivore (meat-only) diet can improve quality of life and reduce symptoms in 160 adults with inflammatory bowel disease (Crohn's or ulcerative colitis) or rheumatoid arthritis. Participants are randomly assigned to one…

This study watches people who already got a gene-modified Treg treatment for rheumatoid arthritis or hidradenitis suppurativa. Researchers want to see if any delayed side effects show up over time. About 36 participants will be followed to track safety and how long the modified c…

This study aims to find out why some people with rheumatoid arthritis have trouble swallowing. Researchers will use a small camera to look at the throat and voice box in 137 adults with RA. The goal is to identify factors that predict swallowing difficulty and see if the camera t…

This study is for adults aged 40-79 with rheumatoid arthritis who have at least one heart disease risk factor (like high blood pressure or smoking). It aims to find better ways to detect early signs of heart disease using heart scans and blood tests. The goal is to identify high-…

This study looks at 200 adults with autoimmune joint diseases like rheumatoid arthritis and psoriatic arthritis. Researchers will measure markers of oxidative stress in their blood at three visits over one year. The goal is to see if these markers can help track disease progressi…

This study is testing whether a blood test can predict how well a lower dose of the drug rituximab works for people with rheumatoid arthritis. Researchers will compare the predicted response to what actually happens in 30 adults. The goal is to see if a simple test can help docto…

This study explores whether medications with anticholinergic effects increase the risk of bone fractures in people with rheumatoid arthritis. Researchers will track 100 patients, measuring their anticholinergic load and using the FRAX tool to estimate fracture risk. The goal is t…

This study looks at the link between nutrition and disease activity in people with rheumatic diseases like rheumatoid arthritis, lupus, and psoriatic arthritis. Researchers will assess the nutritional status of 460 participants using several standard tools and compare it to how a…

This study looks at whether a type of artificial intelligence (AI) can help doctors better identify complications in people with rheumatoid arthritis (RA). Researchers will use AI to suggest possible complications from patient records and see if doctors agree with and use those s…

This early-stage study tests the safety of a new drug called CIGB-814 in 70 healthy adults aged 18 to 45. Researchers will measure how the drug moves through the body and how the immune system responds. This is a first step before testing the drug in people with rheumatoid arthri…

This early-stage study tests a single injection of a new drug called SHR-3045 in 16 healthy adults. The main goal is to check if it is safe and how the body processes it. This is the first step before testing it in people with rheumatoid arthritis.

This study checks if the Four Square Step Test (FSST) is a good and reliable way to measure balance in people with rheumatoid arthritis (RA). Researchers will test 50 adults with RA to see how well the FSST works and how it relates to their pain, quality of life, and muscle stren…

This study looks at the best way to give COVID-19 booster and flu vaccines to people with weakened immune systems, such as those with rheumatoid arthritis, HIV, or organ transplants. Researchers will compare giving both vaccines at the same time versus one month apart, and also t…

This study tracks 70 people who have already received an infusion of KYV-101, a CAR T cell therapy, for autoimmune diseases like lupus, multiple sclerosis, and rheumatoid arthritis. The goal is to watch for delayed side effects, new cancers, or other health problems over up to 15…

This large observational study will follow at least 10,000 people with rheumatoid arthritis (RA), including those with hard-to-treat RA or related lung disease. Researchers will collect data on symptoms, treatments, and side effects from both Traditional Chinese and Western medic…