RHEUMATOID ARTHRITIS (RA)

This early-stage study tests whether a single infusion of a patient's own modified immune cells (CAR-T cells) is safe for people with severe autoimmune diseases like lupus, rheumatoid arthritis, and scleroderma that haven't responded to standard treatments. The study will closely…

This study tests a new medicine called MTM-H-001 in 75 adults with B-cell-related autoimmune diseases such as lupus, multiple sclerosis, and rheumatoid arthritis. The goal is to see if the drug is safe and can help control disease activity. Participants will receive the drug and …

This study tests two different methods for slowly reducing steroid medication in people with rheumatoid arthritis whose disease is stable. About 206 adults will be randomly assigned to either a split-dose or a 1 mg-by-1 mg tapering schedule and followed for six months. The goal i…

This study tests an experimental capsule called QLS12010 in 180 adults with moderate-to-severe rheumatoid arthritis. Participants will receive either one of three doses of the drug or a placebo for 12 weeks. The goal is to see if the drug reduces disease activity and joint swelli…

This early-phase study tests a new treatment called BEN301 for people with autoimmune diseases like scleroderma, rheumatoid arthritis, Sjogren's syndrome, and inflammatory muscle diseases. BEN301 uses specially engineered immune cells (CAR-Tregs) to calm the overactive immune sys…

This study looks at how two types of rheumatoid arthritis (RA) drugs—anti-TNF-α and non-TNF-α—affect exercise ability, muscle strength, tiredness, and heart disease risk. Researchers will measure oxygen use during cycling in 40 adults with RA who have been on one of these drugs f…

This early-stage study tests a new drug called KT502 in 27 adults with moderate to severe rheumatoid arthritis who haven't responded well to other treatments. The goal is to check if the drug is safe, what side effects it may cause, and how the body processes it. Participants wil…

This early-phase study tests an experimental drug called S-4321 in 24 adults with autoimmune diseases like rheumatoid arthritis, psoriasis, lupus, or eczema. The main goal is to check safety and how the body processes the drug. Researchers will also look at early signs of effecti…

This study tests whether a personalized exercise program created by artificial intelligence can improve knee movement and reduce pain in people with rheumatoid arthritis. 147 adults with mild-to-moderate arthritis will be split into three groups: one using the AI system, one usin…

This study tests whether a gentle electrical stimulation (subthreshold stimulation) can reduce fatigue and improve leg muscle function in people with rheumatoid arthritis. 84 participants will be randomly assigned to receive either the real stimulation or a sham (fake) treatment.…

This study tests a new way for people with rheumatoid arthritis to monitor their health from home using an online platform guided by a nurse. About 104 adults who recently had a flare-up or medication change will try the tool for 16 months or start with usual care first. The goal…

This study tests whether a 6-week progressive resistance training program can improve muscle strength in adults with rheumatoid arthritis (RA). About 118 participants will be split into two groups: one does the exercise program, the other continues usual care. Researchers will me…

This study tests whether adding lavender aromatherapy massage to standard care can reduce pain and improve wrist movement in people with rheumatoid arthritis. About 100 adults aged 20 to 60 with stable medication will be randomly assigned to receive the massage plus usual care or…

This study tests two non-drug approaches—pain education and vagus nerve stimulation—against traditional exercise for improving pain and quality of life in people with rheumatoid arthritis. About 36 adults with RA will be assigned to one of three 8-week programs. The goal is to se…

This study looks at how fear of movement (kinesiophobia) is linked to physical function, disease activity, pain, fatigue, depression, anxiety, and muscle loss in adults with rheumatoid arthritis. Researchers will compare 200 RA patients with 200 healthy volunteers to understand t…

This study looks at whether two proteins, MMP7 and MMP9, can be used as a screening tool for interstitial lung disease (ILD) in people with rheumatoid arthritis (RA). Researchers will compare three groups: RA patients with ILD, RA patients without ILD, and healthy volunteers. The…

This study looks at whether people with rheumatic diseases (like rheumatoid arthritis or ankylosing spondylitis) have higher levels of harmful molecules called AGEs compared to healthy people. AGEs build up over time and can cause inflammation. Researchers will use a non-invasive…

This study looks back at medical records from 3,500 adults who had a first-time knee replacement to compare different implant brands. The goal is to see which ones work best over the medium and long term in terms of knee function, safety, and cost. Results will help surgeons and …

This study looks at a blood protein called FAP, which is linked to tissue scarring and inflammation. Researchers will measure FAP levels in people with rheumatoid arthritis, systemic sclerosis (scleroderma), and healthy volunteers. The goal is to see if FAP levels relate to disea…

This study looks at whether the arthritis drug sulfasalazine makes the standard diabetes blood test (HbA1c) unreliable. The drug can shorten red blood cell life, which may lower HbA1c levels and hide true blood sugar problems. Researchers will use continuous glucose monitors to g…

This study will use a high-tech blood test (mass spectrometry) to look at different immune cells in 500 people with various autoimmune diseases and healthy volunteers. The goal is to find patterns that could help doctors screen for and diagnose these conditions earlier. No new tr…

This study follows 150 people at different risk levels for rheumatoid arthritis (RA) to see what factors—like smoking, diet, or stress—might lead to the disease. Participants include those with high RA antibodies, relatives of RA patients, and newly diagnosed patients. The goal i…