Gentle zaps may ease RA fatigue and boost leg power
NCT ID NCT07367438
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether a mild electrical stimulation (called subthreshold stimulation) can reduce fatigue and improve leg muscle function in people with rheumatoid arthritis. Researchers will also measure inflammation and daily function. The study will include 84 adults aged 30-55 with RA for at least 5 years. Half will receive the real stimulation, half a sham treatment, and results will be compared.
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Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 84 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Feb 2026
An estimate. Start dates often move.
- Expected to finish
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May 2026
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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30 to 60 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
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Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Sixty patients with rheumatoid arthritis based on physician diagnosis and referral. * The patients' ages ranged from 30 to 55 (Tedeschi et al., 2013). * Body mass index ranged from 25-30 kg/m2. * Patients diagnosed with rheumatoid arthritis 5 years ago. Exclusion Criteria: * Patients had chronic heart failure, cancer, chronic kidney disease, infection, and any other autoimmune disease (García-Morales et al., 2020). * Patients had unstable ischemic heart disease or arrhythmia (Lange et al., 2019). * Patients had joint surgery within 6 months before inclusion which did not allow them to perform physical activity as arthroplasty (Lange et al., 2019). * Patients had received biologics for RA treatments (Lange et al., 2019).
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The official record
The full official record for this study. This one lists no contact details, but it is the first place any would appear.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
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Other studies related to the condition(s) this trial covers.
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