RENAL CELL CARCINOMA

This study tested whether adding nivolumab (an immunotherapy) to tivozanib (a targeted therapy) helps people with advanced kidney cancer whose disease worsened after one or two prior treatments, including an immunotherapy. About 343 adults participated. The main goal was to see i…

This study tested whether combining two drugs—pembrolizumab (an immunotherapy) and axitinib (a targeted therapy)—works better than the standard drug sunitinib alone for people with advanced kidney cancer. Over 860 participants received either the combination or sunitinib as their…

This study tested a combination of two drugs, pembrolizumab and lenvatinib, in 160 people with a rare type of advanced kidney cancer that had not been treated before. The goal was to see if the drugs could shrink tumors and control the disease. While the treatment may help manage…

This study tested whether transferring gut bacteria from people who responded well to immunotherapy could help others with advanced kidney cancer. Fifty patients received either a fecal transplant or a placebo alongside their standard immunotherapy. The goal was to see if this ap…

This study looked at how safe and effective the drug Cabozantinib is for people aged 70 and older with advanced kidney cancer. Researchers tracked side effects and tumor response in 100 participants. The goal was to see if this treatment is a good option for older patients who ha…

This study tested a personalized vaccine made by fusing a patient's own tumor cells with immune-stimulating cells from a healthy donor. The goal was to see if these injections are safe and can help the immune system attack advanced kidney cancer. 40 adults with stage IV kidney ca…

This early-phase study tested a combination of two experimental drugs (vobramitamab duocarmazine and lorigerlimab) in 31 people with advanced solid tumors like prostate, melanoma, and pancreatic cancer. The main goal was to check safety and find the right dose. Participants recei…

This study tested whether the immunotherapy drug pembrolizumab (Keytruda) can help prevent kidney cancer from coming back after surgery to remove the kidney. Nearly 1,000 adults with intermediate-to-high risk of recurrence received either pembrolizumab or a placebo every three we…

This early-phase study tested a drug called gevokizumab alongside standard cancer treatments in 167 adults with advanced colorectal, stomach, or kidney cancer. The goal was to find a safe dose and see if the combination helps control tumor growth. While not a cure, it aims to imp…

This study tested a new type of stem cell transplant for children and young adults (ages 2-21) with cancers that came back or didn't respond to treatment. The approach uses a special cell filter to speed up immune recovery after transplant. The main goal was to see if the procedu…

This study tested a fast-recovery program for people having minimally invasive kidney surgery (laparoscopic or robotic) to remove kidney tumors. The goal was to see if the program could safely shorten hospital stays by at least one day without increasing complications. Sixty adul…

This study looked at whether taking the kidney cancer drug cabozantinib with a light breakfast could reduce side effects like nausea and diarrhea, and possibly allow patients to skip doses sometimes. Twelve adults with advanced kidney cancer who were already on a stable dose of c…

This study looked at whether people with advanced cancer (melanoma, kidney, or lung cancer) who are starting immunotherapy can collect tiny blood samples at home using a finger-prick method. The goal was to see if this approach is practical and if the samples are good enough for …

This study involved 91 adults with advanced kidney cancer. Researchers collected blood and urine samples over 16 weeks to see if tiny particles called exosomal miRNAs change with treatment. The goal was to find out if these changes can predict whether the cancer responds to thera…

This study tested whether analyzing the genetic makeup of a child's tumor could help doctors choose better treatments. 186 children with cancers that had come back or were not responding to standard therapy took part. The goal was to see if this approach was practical and safe, n…

This study collected tumor tissue, blood, and urine samples from 8,000 children and young adults with kidney tumors. The goal was to store these samples for future research to find DNA changes and biomarkers linked to cancer. No new treatments were tested; instead, the study focu…

This study explored whether small particles called exosomes, found in blood and urine, can help predict how well advanced kidney cancer responds to treatment. Researchers followed 91 adults receiving standard therapies and collected samples over 16 weeks. The goal was to find pat…

This study looked at how immune checkpoint inhibitors, a type of cancer drug, might cause artery disease in 39 people with cancer. Researchers used ultrasound and blood tests to find early signs of blood vessel damage. The goal was to better understand these side effects, not to …