PREGNANCY COMPLICATIONS

This study tests whether an automated insulin delivery system (CamAPS FX) can help women with type 1 diabetes maintain better blood sugar control before and during pregnancy, compared to their usual insulin routine. The trial will enroll 305 women aged 18-45 who are either planni…

This study looks at whether giving pregnant people at risk of preterm birth a single half-dose of a steroid called Celestone works as well as the usual double dose to prevent serious health problems in their babies. About 3,250 participants will be randomly assigned to receive ei…

This study tests whether wearing a continuous glucose monitor and joining a group chat with other pregnant participants can help keep blood sugar levels healthy. High blood sugar during pregnancy can cause problems for both mother and baby. The researchers hope that seeing real-t…

This study tests whether adding certolizumab (Cimzia) to standard care (heparin and aspirin) can prevent fetal death or early delivery in pregnant women with antiphospholipid syndrome (APS) and lupus anticoagulant. About 55 women will receive the drug early in pregnancy and be co…

This study looks at whether starting hepatitis C treatment during pregnancy works well for women who have used drugs. About 50 pregnant adults will take the medication glecaprevir-pibrentasvir and be followed for a year. Researchers will measure how well participants stick to the…

This study tests whether taking low-dose aspirin for six months after childbirth can help blood vessels heal and lower blood pressure in women who had preeclampsia. About 60 new mothers will receive either aspirin or a placebo. The goal is to see if this simple treatment can redu…

This study tests whether adding a specially trained doula to usual home blood pressure monitoring helps women with pregnancy-related high blood pressure achieve better blood pressure control one year after giving birth. About 454 women who had preeclampsia, eclampsia, or gestatio…

This study tests whether providing money specifically for healthy foods during pregnancy can help women avoid gaining too much weight. About 1,440 pregnant women will either receive standard care or extra funds (up to $3,000) to buy nutritious foods. Researchers will compare weig…

This study tests a new method called U-CaVIT, which uses a balloon placed in the uterus to prevent severe bleeding after a C-section in women at high risk. About 70 participants will either get standard care or standard care plus the balloon. The goal is to see if the balloon red…

This study tests whether adding a blood thinner (low molecular weight heparin) to daily low-dose aspirin can prevent preeclampsia in pregnant women at high risk. Preeclampsia is a serious condition causing high blood pressure and organ damage. The trial will enroll 100 women earl…

This study tests two different pain relief methods—propofol sedation versus spinal analgesia—during a procedure to turn a breech baby (external cephalic version). The goal is to see which method helps more babies get into the head-down position for a safer vaginal birth. About 27…

This study tests whether a buprenorphine patch can reduce withdrawal symptoms when pregnant women with opioid use disorder start sublingual buprenorphine treatment. Forty participants will receive either a real patch or a sham bandage during the initial withdrawal period. Researc…

This pilot study tests a simple strength and resistance exercise program designed for high-risk pregnant women who are on bed rest in the hospital. The goal is to see if these gentle movements can improve their physical health, mood, sleep, and overall quality of life compared to…

This study follows 500 mother-child pairs where the mother has a severe hemophilia A gene. Researchers want to learn why some mothers have heavy bleeding after childbirth and why some children develop antibodies to factor VIII treatment. By observing families over time, the study…

This study looks at whether women with gestational diabetes (GDM) experience muscle loss, known as sarcopenia, and how this might affect pregnancy outcomes and thinking skills. Researchers will test 200 pregnant women using muscle strength and function tests, along with standard …

This study is testing two new ultrasound techniques to see if they can tell the difference between healthy pregnancies and those affected by fetal growth restriction (FGR), where the baby is smaller than expected. Researchers will scan 60 pregnant women every three weeks using a …

This study looks at how the natural microbes and chemical profiles in couples' bodies relate to IVF outcomes. Researchers will collect samples from 1000 couples and track whether they have a baby, miscarriage, or other pregnancy results. The goal is to find patterns that might he…

This study looks back at the pregnancy histories of 50 women who were later diagnosed with lupus. Researchers want to see if problems like miscarriage or pre-eclampsia happened before the lupus diagnosis. By comparing pregnancies before and after diagnosis, they hope to find patt…

This study tests an iPad app called Periviable GOALS that helps parents facing a very early preterm birth (22-25 weeks) understand their options and clarify their values. The app includes videos and outcome information designed for people with varying literacy levels. Researchers…

This study looks at how cells in the placenta behave in pregnant women with complications like preeclampsia or poor fetal growth. Researchers will measure specific proteins to understand cell cleanup and death processes. The goal is to learn more about these conditions, not to te…

This study is a worldwide registry that will follow about 10 women with Fabry disease who received the drug pegunigalsidase alfa around the time of pregnancy or while breastfeeding. Researchers will track pregnancy outcomes and infant health for up to one year after birth. The go…

This study follows 6,000 pregnant women in rural Pakistan to understand how high temperatures impact pregnancy and birth outcomes. Researchers will track heat exposure, collect blood and urine samples, and monitor mothers and babies for up to a year after birth. The goal is to id…

This study looks at how a pregnant person's metabolism—specifically insulin resistance and fat burning—may be linked to placenta health and pregnancy complications like preeclampsia and gestational diabetes. Researchers will follow 50 pregnant women at high or moderate risk for p…

This study looks at how things like pregnancy complications, birth weight, and early childhood exposures may influence long-term health for both mothers and children. Researchers are following 24,000 families to track conditions like asthma, allergies, obesity, and high blood pre…

This study follows 40 pregnant women with Lyme disease to see how the infection might affect their baby's development. Researchers will monitor pregnancies and check infant growth, thinking, and motor skills from birth to 18 months. The goal is to learn if Lyme exposure in the wo…

This study looks at how pregnant women sleep, focusing on the positions they spend the most time in and how often they snore. About 500 women who are at least 28 weeks pregnant will use a sleep monitor at home. The goal is to learn more about sleep patterns during pregnancy and s…

This study uses bedside ultrasound to measure muscle loss, fat changes, and fluid buildup in critically ill pregnant and gynecological patients. Researchers will track 121 women in the ICU to see if these body changes relate to serious outcomes like death, need for a breathing ma…

This study looks at how pregnant women at risk for preeclampsia process aspirin and how that relates to signs of metabolic problems. Researchers will measure aspirin breakdown products and other health markers in blood and urine. The goal is to better understand why some women st…

This study looks at whether routine blood sugar tests (like fasting glucose and HbA1c) can predict gestational diabetes in pregnant women who have had bariatric surgery and cannot tolerate the standard sugary drink test. Researchers will follow 84 women throughout pregnancy to se…