PERIODONTAL DISEASES

This study tests whether adding a special anti-inflammatory mouthwash to a deep-cleaning procedure (MINST) helps heal advanced gum disease better than deep cleaning alone. Twenty adults with severe gum disease will be randomly assigned to use either the active mouthwash or a plac…

This study tests whether using a special light device (dual-light antibacterial therapy) or a powered toothbrush can improve gum health and reduce bad breath in older adults (age 60+) who have gum disease and mild memory problems. Ninety participants will be split into three grou…

This study looks at how well 3D-printed, custom-fit bone grafts work for people who need dental implants after losing bone from gum disease. Researchers will check if the implants stay stable and how much the graft shrinks over 1 to 6 years. About 100 healthy adults who already r…

This study aims to develop and validate a new, non-invasive saliva test that uses artificial intelligence (AI) to detect periodontitis (gum disease) early. Researchers will collect saliva samples from 200 adults—some with gum disease and some healthy—and use a special sensor and …

This study will check if simple methods like mouth photos, smartphone images, X-rays, and questionnaires can accurately find gum disease compared to a standard dental exam. About 2,000 adults will take part across five centers. The goal is to develop AI tools that make screening …

This study aims to see if a self-reported questionnaire can accurately identify gum disease (periodontitis or gingivitis) in adults in Saudi Arabia. About 291 participants will fill out the questionnaire and then receive a standard dental exam on the same visit. The results will …

This study aims to validate an Italian version of a widely used gum disease screening questionnaire and develop an improved version with extra questions. Researchers will enroll 495 adults across 10 Italian centers to see how accurately the questionnaire identifies people with pe…

This study tests a new program that teaches pregnant women in Bangladesh how to care for their teeth and gums during routine prenatal visits. Over 95% of pregnant women in Bangladesh have gum disease, but oral health is not part of standard pregnancy care. The study will enroll 6…

This study tests three techniques for removing a tiny amount of enamel between teeth to make room during clear aligner (like Invisalign) treatment. Seventy-five adults will be randomly assigned to one of three methods: manual strips, motor-driven strips, or abrasive discs. The ma…

This study will check levels of a gene called klotho, certain bacteria, and viruses in 108 people with and without gum disease and heart problems. The goal is to see if these factors are linked to both conditions. Participants will have their gums examined and samples taken. The …

This study aims to find out if tiny plastic particles, called microplastics, are present in the deep gum pockets of people with severe gum disease (periodontitis). Researchers will collect plaque samples from 25 adults with advanced gum disease who have not yet started treatment.…

This study compares levels of oxidized LDL (a type of 'bad' cholesterol linked to heart disease) in the gum fluid of people with advanced gum disease versus those with healthy gums. Researchers aim to understand how gum inflammation might affect overall health, especially heart d…

This study looks at whether teeth that bear more chewing force are more likely to have severe gum disease. Researchers will measure bite patterns in 50 adults with natural teeth or fixed dental work. The goal is to understand the link between chewing loads and gum health, which c…

This study follows 100 adults with healthy gums or various stages of gum disease for two years. Researchers will collect saliva and plaque samples to measure specific biomarkers and see if they can predict who will get worse. No treatment is given—the goal is simply to learn whic…

This study will look at the teeth, mouth, face, and quality of life of 25 people with Mowat-Wilson syndrome, a rare genetic condition. Researchers will measure things like cavities, jaw alignment, and facial shape using photos and scans. The goal is to better understand the denta…

This study will measure certain proteins and stress markers in saliva and fluid around dental implants and teeth. Researchers want to see if these markers can help detect and track bone destruction in people with peri-implantitis or periodontitis. 80 healthy volunteers and patien…