PARKINSON'S DISEASE (PD)

This study looks at the long-term safety of the drug buntanetap in 500 people with Parkinson's disease over 36 months. It includes two groups: those who have taken buntanetap before and those who have a deep brain stimulation device. Participants take one 30 mg pill daily, and re…

This study is testing whether a 6-month program combining exercise, mindfulness training, and nutrition guidance can improve thinking, movement, sleep, and overall health in people with Parkinson's disease. Researchers will also look at changes in inflammation, gut bacteria, and …

This study is testing a new, non-invasive eye scan to see if it can detect Parkinson's disease in its early stages. Researchers will compare the scan's accuracy against standard brain imaging in 200 participants, including people with early Parkinson's, related movement disorders…

This study tests whether a new radioactive tracer called [18F]ACI-15916 can safely and reliably detect abnormal alpha-synuclein protein in the brain using PET scans. About 46 people—some healthy and some with suspected Parkinson's, Lewy body dementia, or multiple system atrophy—w…

This study tests a wearable robotic exoskeleton to see if it can improve mobility, balance, and walking in healthy older adults and people with Parkinson's disease, who are at high risk for falls. About 26 participants will attend two lab sessions to perform tasks like walking an…

This study tests a new method to program deep brain stimulation (DBS) for Parkinson's disease using the brain's own electrical signals, instead of the usual manual trial-and-error. Researchers will compare two signal-based approaches to see which one improves motor symptoms like …

This study tests if atomoxetine, a medication that boosts noradrenaline, can reduce freezing of gait in people with Parkinson's disease. About 60 participants will take either atomoxetine or a placebo and perform walking tests, MRI scans, and questionnaires. The goal is to see if…

This study tests a new, non-invasive device that uses gentle electrical currents to stimulate the brain and reduce hand tremors in people with Parkinson's disease. The device is 'closed-loop,' meaning it reads your tremor and delivers stimulation in sync with it. The study will e…

This study tests a new online group therapy program for people diagnosed with Parkinson's disease before age 65. The therapy, called Acceptance and Commitment Therapy (ACT), helps participants cope with difficult thoughts and feelings related to their condition. Researchers will …

This small pilot study tests a smart shoe called NUSHU that provides gentle vibrations to see if it can help people with Parkinson's disease walk faster. Sixteen participants will complete two short walking tests—one with the vibration on and one with it off—to compare their spee…

This study tests if magnetic stimulation applied to the spine, combined with brain stimulation, can improve walking and balance in people with Parkinson's disease. Thirty participants will receive 10 sessions of either neck or upper-back stimulation. The goal is to find which spo…

This study tests whether a new oral drug, AX-5006, is safe and tolerable in healthy adults and people with Parkinson's disease. It involves three parts: single doses, multiple doses over a week, and daily doses for 28 days. The goal is to gather safety data before larger trials.

This study aims to make deep brain stimulation (DBS) programming easier and more personalized for people with Parkinson's disease. Researchers will compare patients' own ratings of how well the stimulation works with electrical signals recorded from the brain. By finding patterns…

This study tests whether a new drug called SUL-238 can improve energy production in brain cells of people with early, untreated Parkinson's disease. About 45 participants will take either SUL-238 or a placebo daily for 28 days. Researchers will use special MRI scans to measure br…

This early-phase study tests a new imaging drug called [18F]MK-0947 that works with PET scans to show clumps of a protein called alpha-synuclein in the brain, which are linked to Parkinson's disease. About 22 adults with Parkinson's and healthy volunteers will receive the drug an…

This study looks at whether recording brain signals during deep brain stimulation (DBS) can help doctors choose the best stimulation settings for people with Parkinson's disease. About 40 participants will have their brain signals recorded during routine hospital visits. The goal…

This study looks at how well people can control their hip muscles and whether that affects their balance, walking, and fall risk. Researchers will compare healthy adults of different ages with people who have Parkinson's disease. The goal is to better understand what causes balan…

This study tests the safety of taking febuxostat and inosine together twice daily for 12 weeks in 24 adults with early-stage Parkinson's disease. Participants must be on stable Parkinson's medications and will have regular blood tests and checkups. The main goal is to measure cha…

This study tests a new PET scan tracer to measure a protein called Hsp90 in the brain. Hsp90 helps proteins fold correctly, and problems with this process are linked to Alzheimer's, Parkinson's, and ALS. Researchers will scan 48 people—healthy volunteers and patients—to see if th…

This study follows 1,573 Canadians aged 50–90 with various types of dementia or normal memory to track how brain health changes over time. Participants complete memory tests, brain scans, and provide blood samples. The goal is to better understand different forms of dementia, not…

This study looks at how two brain circuits involved in movement and speech work when people learn new sound sequences. Researchers will temporarily turn deep brain stimulation (DBS) on or off in 80 adults with Parkinson's disease or essential tremor while they perform speech task…

This study is following 600 people with Parkinson's disease and 100 with multiple system atrophy over time. Researchers are collecting medical history, biological samples, brain scans, and regular check-ups every six months. The goal is to find early signs of disease, improve dia…

This study is testing whether low-intensity focused ultrasound (LIFUS) can safely change brain activity in people with conditions like Parkinson's disease, essential tremor, epilepsy, or substance abuse disorder. Researchers will measure brain responses and any changes in movemen…

This study looks at why people with Parkinson's disease have trouble activating their leg muscles. Researchers will test if stimulating a nerve in the neck (vagus nerve) can improve muscle activation, walking, and balance. The study involves 75 participants and aims to better und…