PARKINSON'S DISEASE (PD)

This early-stage study tests a single injection of special nerve cells (NouvNeu001) in 10 people with moderate-to-advanced Parkinson's who have already had deep brain stimulation or similar brain surgery. The main goal is to check if the injection is safe and tolerable. Researche…

This study tests whether terazosin, a drug currently used for high blood pressure, can improve energy metabolism in people with Parkinson's disease. Researchers will measure changes in a key energy molecule (ATP) in the blood of 120 participants over 6 weeks and 1.5 years. The go…

This early-stage study tests a new way to deliver deep brain stimulation (DBS) for Parkinson's disease. Instead of constant high-level pulses, 'Coordinated Reset' DBS uses lower, patterned stimulation. Researchers will check if it is safe and can improve movement in 24 adults alr…

This early-stage study tests a gene therapy called AAV2-hAADC in 9 adults aged 18-75 with young onset Parkinson's (symptoms before age 50). The therapy delivers a gene into brain areas that help turn levodopa into dopamine, the chemical missing in Parkinson's. The main goal is to…

This early-stage trial tests a new gene therapy for Parkinson's disease. Six adults aged 40-70 with advanced Parkinson's will receive a brain injection of a specially designed virus (STP-001) that delivers a gene to calm overactive brain cells. After surgery, they will take a pil…

This study tests whether community-based screening and new treatments—including stem cell therapy and wearable brain-computer interface devices—can slow or stop memory loss in adults 55 and older with mild cognitive impairment (MCI). Researchers will enroll 600 participants acros…

This early-phase study tests a new imaging drug called SST001 in 30 healthy adults and people with multiple system atrophy (MSA) or Parkinson's disease. The main goal is to check if SST001 is safe and how it spreads in the body using PET scans. Researchers hope it may help doctor…

This study tests a remote system that uses gentle vibrations (haptic feedback) to guide arm movements for people with Parkinson's disease. Twenty participants will use the system at home for 8 weeks to see if it improves movement accuracy, speed, and smoothness. The goal is to ma…

This study will test two different physical therapy approaches—strategy training and proprioceptive neuromuscular facilitation—to see which one better helps people with Parkinson's disease improve their balance, walking, and ability to do daily tasks. About 42 adults aged 40 to 8…

This study tests a robotic device called BackHug that delivers deep back massages to people with mild-to-moderate Parkinson's disease. The goal is to see if it can improve walking, reduce back pain, and help with sleep. Thirty adults will receive 40-minute sessions over several w…

This study tests whether long-term training with an AI-powered smart electric vehicle can improve walking speed, balance, and confidence in people with Parkinson's disease or dementia. Researchers will enroll 120 adults aged 50-85 who can walk at least 10 meters but may have an u…

This study looks at how abnormal proteins build up and spread in the brains of people with Parkinson's disease. Researchers will use brain scans, blood tests, and thinking assessments to understand the disease better. The goal is to create a computer model of the brain to predict…

This study looks at how doing mental tasks—like naming objects or remembering words—changes the way people with Parkinson's disease walk. Researchers will compare 30 people with Parkinson's to healthy volunteers of the same age and sex. The goal is to find out which type of think…

This study tests a new automated method (Illumina 3D) for programming deep brain stimulation (DBS) devices in people with Parkinson's disease. Fifteen participants who recently received a DBS implant will try the automated settings and perform motor tasks like walking and finger …

This study looks at gut changes in people with untreated Parkinson's disease compared to healthy adults. Researchers want to see if the stomach lining and gut bacteria are different in early Parkinson's. The study does not test any treatment, but aims to help scientists better un…