PARKINSON DISEASE (PD)

This study tests a new treatment called XS411, made from stem cells, for people with early-onset Parkinson's disease. It involves a single injection into the brain to replace damaged cells. The trial has two parts: first, a small group to check safety, then a larger group to see …

This early-stage study tests whether transplanting 10 million special stem cells into the brain is safe for people with moderate Parkinson's disease. Ten participants aged 30 to 70 will receive the cells in a single surgery. The main goal is to check for side effects and see if t…

This study tests whether a daily dose of D-serine, an amino acid, can slow the progression of Parkinson's disease. One hundred people with early-stage Parkinson's will receive either D-serine or a placebo for 58 weeks, followed by a 12-week break. Researchers will measure changes…

This early-stage study tests a new treatment called PDR-001 for people with Parkinson's disease. The treatment is a peptide delivered directly into the brain to clear a harmful protein called alpha-synuclein, which is linked to Parkinson's. The main goal is to check safety in 12 …

This study is testing a new blood test to detect Parkinson's disease early, before symptoms become severe. Researchers will compare blood samples from 600 people with Parkinson's and 600 healthy volunteers over two years. The goal is to find reliable markers in the blood that cou…

This study tests a new radioactive imaging agent called 18F-mFBG to see if it can detect nerve damage in the heart caused by Parkinson's disease and Lewy body dementia. About 20 adults with and without these conditions will receive the agent and have PET scans. The goal is to imp…

This study tests whether adding robot-assisted walking training or electrical muscle stimulation to standard exercise helps people with Parkinson's disease walk better and feel steadier. About 40 adults with mild-to-moderate Parkinson's will take part in 6 weeks of daily sessions…

This study looks at how different types of exercise affect movement, balance, and quality of life in people with Parkinson's disease. About 45 adults with mild to moderate Parkinson's will take part in supervised exercise sessions for 8 weeks. Researchers will measure walking, ba…

This study explores whether people with Parkinson's disease can improve their quality of life, walking speed, and mobility by managing their own exercise plans at home using telerehabilitation. Researchers will compare the results to those from a supervised exercise program. The …

This study tests a wearable leg sleeve called the Cionic Neural Sleeve for people with Parkinson's disease who have trouble walking. Ten participants will use the device at home to see if it is safe and easy to operate on their own. The goal is to learn whether the sleeve can be …

This study tests whether a daily tailored amino acid supplement can improve nutrition, reduce oxidative stress, and boost physical and mental health in 30 adults aged 60-80 with Parkinson's disease. Participants take either the supplement or a placebo for 6 months and undergo blo…

This study is testing a non-invasive ultrasound device (NaviFUS-ctbTUS) to see if it can safely reduce hand tremors in people with Parkinson's disease, essential tremor, or dystonic tremor. Twelve adults aged 18-80 who don't get enough relief from medication will receive the stim…

This study tests whether adding motor imagery (mentally practicing movements without actually moving) to standard physical therapy can improve balance and reduce fear of movement in people with Parkinson's disease. About 42 participants will be randomly assigned to either standar…

This study tests whether a 12-week program combining physical and mental exercises can improve walking and balance in people with moderate to advanced Parkinson's disease. 48 participants will be randomly assigned to either continue their usual care or add the special exercise se…

This study tests whether a gentle, non-invasive brain stimulation (tDCS) given during a supervised Nordic walking program can improve walking and balance in people with Parkinson's disease. Forty participants will be randomly assigned to receive either real or fake stimulation wh…

This study explores whether a 6-week empathy and compassion training program can improve quality of life for people with Parkinson's disease and their caregivers. Participants will practice mindfulness, writing, and poetry exercises. The study aims to see if these skills help wit…

This study is testing whether special smart socks (called DANU) can accurately measure how people with Parkinson's walk and keep their balance. Researchers will compare the socks' readings to standard lab equipment. The goal is to see if these socks can help predict falls in the …

This study tests whether DANU Smart Socks can accurately measure walking and balance in people with Parkinson's disease. Researchers will compare data from 60 participants (30 with Parkinson's and 30 healthy adults of similar age) during a single lab visit. The goal is to see if …

This study looks at hearing in people with early Alzheimer's or Parkinson's to see if certain hearing problems are more common. Researchers will test hearing in 309 adults aged 50-85, including healthy volunteers. The goal is to find hidden hearing loss (trouble hearing in noise …

This study uses ultrasound to measure the thickness of belly and side breathing muscles in people with Parkinson's disease. Researchers want to see if thinner muscles are linked to more severe disease and weaker exhale strength. About 36 adults with mild to moderate Parkinson's w…