PARKINSON DISEASE (PD)

This early-stage study tests a gene therapy called VGN-R08b in 17 people with Parkinson's disease who have a specific genetic change (GBA1 mutation). The treatment is given as an injection into the fluid around the brain. The main goals are to check safety and see if it can impro…

This early-stage study tests whether a single treatment with human umbilical cord stem cells is safe and tolerable for people with Parkinson's disease. About 20 adults aged 18 to 75 will receive either stem cells or a placebo, and researchers will monitor side effects and any cha…

This study tests a non-invasive treatment called remote ischemic conditioning (RIC) for sleep problems in people with Parkinson's disease. 48 participants with insomnia will receive either active RIC (using a blood pressure cuff) or a sham version for 7 days. Researchers will mea…

This study tests a 16-week home-based exercise program for 50 people with Parkinson's disease who are not very active. Participants will either do aerobic and resistance training or simple stretching, all guided by a coach through video chats. The goal is to see if the program in…

This study tests whether doing two things at once—like moving your arm while thinking—can improve arm function and muscle thickness in people with Parkinson's disease. About 38 participants will either receive dual-task training three times a week for 8 weeks or continue their us…

This study looks at how the nerves connecting the gut and brain might be involved in Parkinson's disease. Researchers will compare people with Parkinson's, those at risk, and healthy volunteers. Participants give blood, stool, and saliva samples, plus undergo X-rays and a scope e…

This study tests whether body-worn sensors at home can help doctors fine-tune Parkinson's medications better than standard care. About 218 people with Parkinson's who have motor fluctuations will wear sensors for 6 months. The goal is to reduce daily "OFF" time (when symptoms ret…

This study will follow 3000 people with Parkinson's disease over 10 years to learn how the disease progresses and what factors affect survival. Participants will have regular check-ups, questionnaires, brain scans, and lab tests, but no experimental treatments are given. The goal…

This observational study looks at how a specific brain function called inhibitory control—the ability to stop or change actions—relates to walking adaptability in people with Parkinson's disease. About 50 participants will complete thinking tests, have brain activity recorded wit…