PAIN, ACUTE

This study tests whether a stellate ganglion block (a nerve injection in the neck) given before mastectomy can prevent depression and chronic pain after surgery. About 140 women with breast cancer will receive either the block or standard care. The goal is to see if this simple p…

This study tests whether taking high-dose vitamin C for two weeks can lower the amount of opioid pain pills people need after leaving the emergency room with acute muscle or bone pain. About 464 adults will be randomly assigned to receive vitamin C or a placebo, and they will tra…

This study tests whether vitamin C can safely reduce pain from recent muscle, sprain, or fracture injuries in emergency patients. About 204 adults with moderate-to-severe pain will receive either vitamin C or a placebo for three days. If effective, vitamin C could offer a cheap, …

This study tests a method called cryoneurolysis, which uses a small tool to freeze the nerves that cause pain from broken ribs. The goal is to see if this approach is practical and can reduce pain and complications. 24 adults with broken ribs will receive this treatment alongside…

This study tests if acu-TENS, a device that sends mild electrical pulses to acupuncture points on the skin, can reduce pain during a procedure to remove pregnancy tissue after a miscarriage. About 108 women will be randomly assigned to receive either real acu-TENS or a sham devic…

This study tests a mobile app called L-WebTIPS, designed to help Latinx children ages 2-7 and their families prepare for and recover from outpatient surgery. The app provides coping skills and information in a culturally adapted format. Researchers will measure whether it reduces…

This study compares three doses of a medicine called dexmedetomidine added to a standard numbing shot for arm surgery. The goal is to see if a higher dose keeps the arm numb and pain-free longer. About 69 adults having elbow, forearm, or hand surgery will take part.

This study tests whether adding a lightweight splint to standard pain relief can reduce pain for adults with a possible wrist fracture in the emergency department. About 120 people with moderate to severe pain will be randomly assigned to get either usual care or usual care plus …

This study is testing whether oxytocin, given as a nasal spray or through an IV, can reduce pain caused by heat on the skin. Researchers will ask 24 healthy adults to rate their pain levels over 4 hours after receiving the drug. The goal is to see how well oxytocin works for pain…

This study tests whether acupressure can reduce pain and improve lung function after chest surgery. About 80 adults who had a thoracotomy will receive acupressure or standard care. The goal is to see if this drug-free method can lower pain and the need for opioids, which can caus…

This study tests whether a small electrical device (TENS) can reduce pain during an outpatient procedure for stress urinary incontinence in women. One hundred women will be randomly assigned to receive either real TENS or a placebo device during the procedure. The goal is to see …

This study tests whether bright blue light therapy can reduce pain and inflammation in adults with painful rib fractures. About 75 hospitalized adults will be randomly assigned to receive blue light, white light, or usual lighting for 4 hours each morning for up to 3 days, in add…

This study tests whether a handheld canister of nitrous oxide (laughing gas) can help control pain and anxiety during burn dressing changes. Thirty adults with burns covering 5-20% of their body will try both the gas and standard care to see which works better. The goal is to fin…

This study looks at how temporary muscle pain in the leg changes the way healthy people walk. Researchers will inject a saltwater solution into leg muscles to cause short-term pain, then measure movement and muscle activity. The goal is to understand pain's effect on walking, not…

This study looks at how pain pathways in the brain and nerve regrowth in the eye change after corneal crosslinking (CXL) for keratoconus. Researchers will use brain scans (fMRI) and special eye imaging to measure these changes in 60 participants aged 8-35. The goal is to better u…

This early-stage study tests the safety of an experimental oral drug called SBS-147 in 80 healthy adults aged 18-55. Some participants get the drug, others get a placebo. The study has two parts: one group takes a single dose, another takes it daily for a week. Researchers will m…

This study is trying to understand why some people get enough pain relief from ibuprofen after having their wisdom teeth removed, while others still need stronger opioid painkillers. Researchers will study 200 adults to look for factors like genes and body chemistry that might ex…