Vitamin c may cut opioid need after emergency room pain
NCT ID NCT05555576
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether taking high-dose vitamin C for two weeks can lower the amount of opioid pain pills people need after leaving the emergency room with acute muscle or bone pain. About 464 adults will be randomly assigned to receive either vitamin C or a placebo. The goal is to see if vitamin C can safely reduce opioid use and help manage pain.
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Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 464 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Nov 2023
- Expected to finish
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Dec 2026
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: 1. Aged 18 and over; 2. Treated in ED for acute musculoskeletal pain present for less than 2 weeks; 3. Discharged with an opioid prescription; 4. Speaks French or English. Exclusion Criteria: 1. Opioid use 1 month prior to the ED visit; 2. Already taking vitamin C supplement; 3. Active cancer; 4. Treated for chronic pain; 5. Treated for opioid use disorder; 6. Unable to fill out diary or unavailable for follow-up; 7. Any allergy, intolerance or sensitivity to milk (lactose) or morphine 8. Treated with cyclosporin or coumadin 9. Pregnant or lactating (dosage \> 1,800 mg not recommended. For women of child-bearing age and sexually active in the past 3 months, a urine pregnancy test will be performed.)
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Hôpital du Sacré-Coeur de Montréal
RECRUITINGMontreal, Quebec, H4J 1C4, Canada
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