OVARIAN CARCINOMA

This early-stage trial tests a new drug, AVA6000, designed to deliver chemotherapy directly to tumor cells while reducing harm to healthy tissue. It is for people with advanced solid tumors (like breast, ovarian, or salivary gland cancer) that have not responded to standard treat…

This study tests a drug called tegavivint in children, teens, and young adults (ages 1 to 30) whose solid tumors have returned or not responded to standard therapy. The drug works by blocking a key signal that tells cancer cells to grow. The trial aims to find the safest dose, un…

This early-phase study tests a new drug, DT2216, combined with the chemotherapy paclitaxel in people whose ovarian cancer has returned and is resistant to platinum-based treatments. The main goal is to find the safest dose of DT2216 when given with paclitaxel. About 30 participan…

This study tests a personalized vaccine made from a patient's own tumor cells and immune cells. The goal is to see if the vaccine can train the immune system to fight ovarian cancer more effectively. Ten women with advanced ovarian cancer will receive the vaccine alongside standa…

This study tests a technique called acute normovolemic hemodilution (ANH) during ovarian cancer surgery. ANH involves removing some blood before surgery and replacing it with fluids, then giving the blood back later. The goal is to see if this reduces the need for donor blood tra…

This early-phase study tests a new daily pill, NKT3964, that breaks down a protein called CDK2 to slow cancer growth. It is for adults with advanced solid tumors (like ovarian, endometrial, breast, gastric, or lung cancer) that have not responded to standard treatments. The study…

This study tests whether the drug belzutifan can shrink or slow the growth of clear cell cancers of the ovary, uterus, cervix, vagina, or vulva that have come back or not gone away. About 32 adults will receive belzutifan pills and be monitored for tumor response and side effects…

This study looks at whether taking the drug olaparib for one year is as good as taking it for two years to keep ovarian cancer from coming back. It includes people with advanced ovarian cancer who have certain gene changes (BRCA or HRD). The goal is to find the best treatment len…

This study tests a new drug called JAB-8263 in adults with advanced solid tumors or blood cancers that have stopped responding to standard treatments. The goal is to find the safest dose and see if the drug can shrink tumors. About 152 people will take part in this early-phase tr…

This study tests whether using a special camera and fluorescent dye during surgery can help surgeons see blood flow in the bowel and reduce the risk of leaks after the operation. About 310 women with ovarian cancer who need bowel surgery will take part. The goal is to see if this…

This study tests an experimental drug called patritumab deruxtecan in people with advanced solid tumors that have spread or cannot be removed. The drug targets a protein called HER3 found on some cancer cells. About 740 adults with various cancers like lung, breast, or melanoma w…

This early-phase study tests a new treatment called CIML NK cell therapy for people with recurrent ovarian cancer that no longer responds to platinum-based chemotherapy. The therapy uses specially trained natural killer cells from a donor to attack the cancer. The study aims to f…

This study tests a new ultrasound method called ultrasound microvessel imaging (UMI) to see if it can better detect blood flow in ovarian growths. Better blood flow detection may help doctors more accurately assess cancer risk. About 40 women scheduled for surgery for ovarian les…

This study is testing a new radioactive tracer called [18F]FTT to see if it can make PET/CT scans better at finding solid tumors, including ovarian, breast, and other cancers. About 300 adults with known or suspected tumors will receive the tracer and then have a PET/CT scan. The…

This study looks at two surgeries for women with BRCA1 gene mutations who are at high risk for ovarian cancer. One surgery removes only the fallopian tubes, while the other removes both tubes and ovaries. The goal is to see if removing just the tubes works nearly as well at preve…

This study tests whether a 16-week virtual exercise program can help patients with ovarian or endometrial cancer maintain leg strength and reduce numbness or tingling caused by chemotherapy. About 30 adults who have had surgery and are starting chemo will participate. The goal is…

This study tests whether a combination of two drugs (propranolol and etodolac) plus mind-body training and music therapy can reduce stress in women with advanced ovarian cancer undergoing surgery. About 35 participants will be randomly assigned to receive this bundle or standard …

This study tests whether giving cancer treatment at home is preferred over going to a clinic. It involves 27 adults with various cancers in the Florida Panhandle. The goal is to see if home care improves patient satisfaction and is safe.

This study tests a new communication tool called CASI for people with advanced ovarian cancer, their caregivers, and doctors. The goal is to see if using this tool helps patients and doctors better discuss what matters most during appointments. About 112 participants will be enro…

This study tests a non-invasive device that gently stimulates a nerve in the ear to see if it can improve quality of life by reducing digestive problems like nausea and bloating during first-line chemotherapy for ovarian cancer. About 116 women will be randomly assigned to receiv…

This study tests a workshop called HOPE-C designed to reduce burnout in doctors, nurses, and social workers who care for ovarian cancer patients. The workshop helps clinicians share their challenging experiences and build peer support. Researchers will enroll 25 participants to s…

This study is testing new blood tests that look for signs of many different cancers at the same time. The goal is to see if these tests can find cancer early, when treatment works best. About 24,000 adults aged 45 to 75 who do not have cancer will take part. They will be placed i…

This study looks at how the immune system reacts to breast and ovarian cancer. Researchers will analyze tumor and blood samples from 160 women before surgery to find patterns that might predict survival. No new treatments are tested—the goal is to gather information that could gu…

This study follows 2,000 people who have had ovarian or other solid cancers to understand why some later develop blood cancers. Researchers will look at genetic changes and treatment history to identify risk factors. The goal is to improve monitoring and prevention for cancer sur…

This study looks at how ovarian cancer affects the immune system, especially in the bone marrow and blood. Researchers will compare immune cells from 90 women with ovarian cancer to those without cancer. The goal is to find ways to retrain immune cells to better attack the tumor,…

This study is gathering tumor tissue and blood cells from 200 adults with advanced solid tumors like colorectal, lung, or pancreatic cancer. The goal is to learn how often certain genetic changes occur and to store participants' own immune cells for possible future use in making …

This study follows 600 Japanese women who carry BRCA1 or BRCA2 gene changes to see how often they develop ovarian, fallopian tube, or peritoneal cancers. Participants are monitored over time, and researchers also check tissue samples from those who choose preventive surgery. The …

This study tests whether a computer-generated character can effectively educate cancer patients about genetic testing, compared to a human genetics counselor. The goal is to see if this approach increases testing rates, especially for minority and rural patients who often lack ac…

This study is gathering information and tumor samples from 2,000 people with low-grade ovarian or peritoneal tumors. The goal is to create a detailed database that helps researchers learn more about these rare cancers and how they are treated. This knowledge may lead to better tr…