OVARIAN CARCINOMA

This is the first study in people to test a new oral medication called NKT3964. The main goals are to find a safe dose and see if the drug shows early signs of shrinking tumors in adults with advanced cancers that have spread and no longer respond to standard treatments. The stud…

This early-stage trial is testing a personalized vaccine for advanced ovarian cancer. Doctors create the vaccine using a patient's own tumor cells and specialized immune cells called dendritic cells. The goal is to see if this vaccine, given alongside standard chemotherapy and su…

This study is testing a new drug called tegavivint in children and young adults whose solid tumors have come back or have not responded to other treatments. The main goals are to find the safest dose, understand the side effects, and see if the drug can help shrink tumors. Tegavi…

This study is testing whether the oral drug belzutifan can help control recurrent clear cell cancers of the ovary, uterus, cervix, and other gynecologic sites. It will enroll 32 adults who have already received platinum-based chemotherapy. Researchers will measure how well the dr…

This is an early-stage study to test the safety and find the right dose of a new experimental drug, JAB-8263, in adults with advanced cancers that have not responded to standard treatments. The trial will enroll about 152 people with various advanced solid tumors (like lung or ov…

This early-stage study is testing a new type of treatment for ovarian cancer that has come back and stopped responding to standard platinum-based chemotherapy. Researchers are collecting a patient's own immune cells, boosting them in a lab to create 'memory-like' natural killer (…

This early-stage study aims to find the safest and most effective dose of an experimental drug called DT2216 when given with standard chemotherapy (paclitaxel) for women with recurrent ovarian cancer that has stopped responding to platinum-based treatments. The trial will enroll …

This is a first-in-human study testing a new cancer drug called AVA6000 in patients with advanced solid tumors that have spread or cannot be removed by surgery. The drug is a modified version of a common chemotherapy (doxorubicin) designed to be activated only inside tumors, pote…

This large trial aims to see if one year of maintenance therapy is just as effective as two years for patients with advanced ovarian cancer who have specific genetic changes and responded well to initial chemotherapy. It will test two drugs, olaparib and bevacizumab, which work t…

This study is testing an experimental drug called patritumab deruxtecan (HER3-DXd) in people with advanced solid tumors that have spread or cannot be removed by surgery. The goal is to see if the drug can shrink tumors and control the disease in people who have already tried at l…

This study is testing whether a blood conservation technique called acute normovolemic hemodilution (ANH) can reduce the need for donor blood transfusions during ovarian cancer surgery. Researchers will randomly assign 86 patients undergoing surgery for advanced ovarian cancer to…

This study is testing two new blood tests designed to screen for 11 different cancers at the same time. It will enroll 24,000 healthy adults aged 45-75 to see how well these tests work for early detection and to understand how people and their doctors respond to the results. The …

This study is testing a new type of ultrasound imaging to see if it can better evaluate growths on or near the ovaries. The goal is to improve the ability to tell if a growth is cancerous before a patient has surgery. Researchers will enroll 40 women who are already scheduled for…

This study is comparing two surgical options to prevent ovarian cancer in women who carry a BRCA1 gene mutation. One surgery removes only the fallopian tubes, while the standard surgery removes both the tubes and ovaries. The goal is to see if the less invasive option is nearly a…

This study is testing a new communication tool designed to help patients with advanced ovarian cancer, their caregivers, and their doctors work together to set priorities for care during clinic visits. It is a pilot study to see if the tool is practical and acceptable to use. The…

This study is testing whether a small device that gently stimulates a nerve in the ear can improve quality of life for women undergoing first-line chemotherapy for ovarian cancer. The device aims to reduce digestive symptoms like nausea and discomfort that often come with treatme…

This study is testing whether cancer patients prefer to receive their standard drug treatments at home instead of in a clinic. Researchers want to see if home-based care reduces the burden of travel and improves treatment satisfaction and quality of life for patients. A specializ…

This study is testing whether a 16-week home exercise program, done over video calls, can help women with ovarian or endometrial cancer who are receiving chemotherapy after surgery. Researchers want to see if the exercise helps patients keep their leg strength and mobility, and r…

This study is testing a new workshop designed to help doctors, nurses, and other clinicians who care for ovarian cancer patients manage work-related stress and burnout. The 4-week program, called HOPE-C, helps participants reframe challenging experiences and build peer support. R…

This study is preparing for future cancer treatment trials by collecting information and materials from patients. Researchers will analyze tumor tissue from people with advanced solid tumors and collect their white blood cells through a procedure called apheresis. The collected c…

This study is testing a new radioactive tracer used in PET/CT scans to see if it can better find and track cancer cells in people with solid tumors, including ovarian, breast, and other cancers. Researchers will inject the tracer and perform scans to see how well it highlights tu…

This study is collecting medical information from 2000 patients with low-grade ovarian or peritoneal cancers to build a comprehensive database. Researchers will review medical records and store tissue samples to better understand these specific tumor types. The goal is to analyze…

This study aims to understand how often and why women with BRCA gene changes develop ovarian, fallopian tube, and peritoneal cancers. Researchers will follow 600 Japanese women with these genetic variants over time, tracking who develops cancer and examining factors like lifestyl…

This study is testing whether a multilingual AI chatbot named PERLA can help more cancer patients get important genetic testing. It compares patients who learn about testing from the chatbot to those who learn from a human genetics counselor. The goal is to see if this technology…

This study aims to understand why some people who have been treated for cancers like ovarian cancer later develop blood cancers or disorders. Researchers will observe 2,000 patients who have had certain cancer treatments to look for genetic and other risk factors. They will colle…

This study aims to understand why the immune system struggles to fight ovarian cancer. Researchers will collect blood, bone marrow, and tissue samples from 90 women—some with ovarian cancer and some without—to analyze their immune cells. The goal is to see if specific agents can …

This study is collecting tissue and blood samples from cancer patients over time to create a research resource called a biobank. Researchers will analyze these samples to understand how cancer changes during treatment and why some treatments stop working. The goal is to help scie…