OVARIAN CARCINOMA

This early-stage study tests an experimental pill, ATV-1601, in people with advanced solid tumors (including certain breast, ovarian, and prostate cancers) that have a specific AKT1 gene mutation. The main goals are to check the drug's safety, find the best dose, and see how the …

This early-phase study tests the safety and best dose of the drug veliparib when given with standard chemotherapy (carboplatin and paclitaxel) in adults with advanced solid tumors that also have liver or kidney dysfunction. The goal is to find out how the body processes the drugs…

This phase 3 trial tests whether adding heated chemotherapy directly into the abdomen during surgery helps people with stage III ovarian cancer live longer without the disease coming back. About 362 participants will receive either standard surgery alone or surgery plus the heate…

This study tests a drug called sacituzumab govitecan in 20 people with ovarian, fallopian tube, or peritoneal cancers that stopped responding to platinum chemotherapy. The drug delivers chemotherapy directly to cancer cells using a targeted antibody. The main goal is to see how m…

This study tested a combination of two drugs, olaparib and cediranib, in 70 people with ovarian, peritoneal, or fallopian tube cancer that had returned after initial treatment. The goal was to see if the drugs could slow or stop tumor growth by blocking enzymes cancer cells need …

This study compares two imaging methods—PET/MR and standard CECT scans—to see which more accurately finds ovarian cancer tumors and predicts if they can be fully removed during surgery. About 21 women with known or suspected ovarian cancer will participate. The goal is to improve…

This study tests different programs to help people at high risk for cancer (such as those with BRCA or Lynch syndrome) or cancer survivors increase their physical activity and eat healthier. The goal is to see which program works best to improve waist size and overall health, whi…

This study looks at three approaches for women with BRCA mutations who are at high risk for ovarian cancer: regular screening, removing both fallopian tubes and ovaries at once, or removing just the fallopian tubes first and the ovaries later. The goal is to see if delaying ovary…

This study tests whether eating a diet high in magnesium can prevent low blood magnesium levels in ovarian cancer patients receiving carboplatin chemotherapy. About 26 women with previously untreated ovarian cancer will follow a magnesium-rich diet for up to 6 cycles of treatment…

This study follows about 400 adults who previously received A2Bio gene therapy for various solid tumors, including lung, colon, and pancreatic cancers. The main goal is to track long-term safety and see how well the treatment effects last over time. Participants do not receive ne…

This study tests a web-based education tool called HOPE-Genomics that teaches cancer patients about their genetic test results. About 465 adults with lung, breast, colorectal, pancreatic, ovarian, or prostate cancer are taking part. The goal is to see if the tool helps patients r…

This study looked at whether regular screening tests for ovarian cancer can help find the disease early and reduce deaths. Over 78,000 women aged 55 to 74 took part, with some getting screening and others getting usual care. Researchers tracked how many women died from ovarian ca…

This study collects tissue and blood samples, along with medical information, from 1,600 people with various advanced cancers. The goal is to track how cancer changes over time and during treatment. Researchers hope this will help them understand why some cancers resist therapy a…

This study tests whether analyzing the genes in a patient's tumor can help doctors choose a more effective treatment. Over 6,400 adults with advanced or hard-to-treat cancers (solid tumors, lymphoma, or myeloma) had their tumors genetically screened. Those with specific genetic c…

This study checks for muscle loss (sarcopenia) in 25 women with advanced ovarian cancer before they start chemotherapy. Researchers use CT scans to measure muscle mass and see how it relates to treatment timing. The goal is to better understand how muscle health affects care, not…