ORAL CANCER

This trial is for people with oral cancer who have completed surgery and standard chemoradiation. Researchers will use a blood test to look for leftover cancer cells (circulating tumor cells). If the test is positive, patients will receive three months of low-dose oral chemothera…

This phase 2 trial is testing whether a 10-day course of the antibiotic metronidazole plus a chlorhexidine mouth rinse can lower the amount of bacteria living inside oral tumors. The study involves 30 adults with oral cancer who are scheduled for surgery. Researchers will compare…

This study tests whether using ultrasound during oral cancer surgery helps surgeons remove tumors more completely. About 150 adults with early-stage oral cancer will be randomly assigned to standard surgery or surgery guided by real-time ultrasound. The goal is to see if ultrasou…

This study compares two non-invasive techniques—a cell-collection brush test and a special microscope—to see if they can accurately detect precancerous and early cancerous spots in the mouth. Researchers will enroll 400 adults with visible mouth lesions. If successful, these meth…

This study is testing a smartphone app that uses artificial intelligence to help people with oral cancer manage symptoms, improve communication, and return to work. The app includes a chatbot for emotional support, posture correction exercises, and a communication aid. Researcher…

This pilot study tests whether brodalumab, a drug used for autoimmune conditions like psoriasis, can safely reduce immune-related side effects caused by cancer immunotherapy. About 11 adults with advanced solid tumors who developed these side effects will receive brodalumab injec…

This study compares two painkiller combinations—dezocine plus sufentanil versus nalbuphine plus sufentanil—for pain relief after oral cancer surgery with flap reconstruction. Sixty adults will receive one of the two combinations through a patient-controlled pump. The goal is to s…

This study tests whether closely watching jaw movement and starting physical therapy early can prevent or reduce trismus (jaw tightness) in people receiving radiation for head and neck cancer. Thirty adults will be checked weekly during treatment and given jaw exercises if their …

This study tests whether a custom dental device called a palatal augmentation prosthesis (PAP), along with speech therapy, can improve how well people speak and swallow after surgery for small tongue cancers (T1/T2). Forty participants will be randomly assigned to receive the dev…

This study tests if starting tongue strengthening exercises soon after tongue cancer surgery can improve speech and swallowing. About 40 adults who are having part of their tongue removed will use a biofeedback device called the Tongueometer to guide their exercises. The goal is …

This study follows oral cancer patients who completed a previous rehabilitation trial to see if AI-based physiotherapy offers lasting benefits over standard therapy. Researchers will check jaw movement, shoulder function, overall physical health, quality of life, and ability to r…

This study tests whether an AI-powered mobile app can help oral cancer patients recover jaw, shoulder, and overall physical function better than standard care. One hundred patients scheduled for surgery, chemo, or radiation will be split into two groups: one using the AI app for …

This study looks at why some people get infections after surgery for oral cancer. Researchers will track 40 patients undergoing standard reconstructive surgery to see where infection-causing bacteria come from and how well antibiotics work. The goal is to find better ways to prev…

This study looks at whether changes in the bacteria living in your mouth and gut (the microbiome) are linked to head and neck cancer. Researchers will collect stool and saliva samples from 60 people—half with cancer and half without—to compare their microbial makeup. The goal is …

This study tests whether an AI system can accurately measure jaw, neck, and shoulder movement in 40 adults—both healthy volunteers and oral cancer patients with stiffness or limited motion after treatment. Researchers will compare AI estimates to standard measurements to see if t…

This study compares pain sensitivity between 40 oral cancer patients and 40 healthy volunteers using pressure and tongue-stretch tests. Researchers aim to understand how nerve cells called Schwann cells contribute to oral cancer pain. No treatment is given; the goal is to gather …

This study checks if an AI-based system can accurately measure how well people can move their jaw and neck-shoulder area, which is important for oral cancer patients. Twenty healthy adults will perform movement tasks while the AI and two human raters take measurements. The goal i…

This study aims to learn more about diseases that affect the salivary glands, which produce saliva. Researchers will collect medical information, blood, saliva, and tissue samples from people with these conditions, their relatives, and healthy volunteers. The goal is to better un…

This study looks at how stiff the jaw muscles are in people who have had treatment for oral cancer. Using a special ultrasound, researchers will measure muscle hardness and see if it relates to how wide a person can open their mouth. They will also test if exercise can improve mo…

This study is for 1000 people with oral cancer or precancerous mouth lesions. Researchers will collect tissue samples and ask participants about their symptoms before, during, and after treatment. The goal is to find better ways to predict how the disease will behave and which tr…

This study tests whether using 3D computer models and printed surgical guides leads to better bone healing than standard free-hand surgery for people needing jaw reconstruction after oral cancer. About 420 adults will be randomly assigned to one of the two methods. The main goal …

This study compares an AI-powered chatbot to traditional educational handouts for teaching African American adults about oral cancer. Researchers want to see which method helps people learn more about prevention, risk factors, and early signs. The goal is to find better ways to s…