Can antibiotics fight oral cancer from the inside? new trial aims to find out
NCT ID NCT06627270
First seen Mar 06, 2026 · Last updated Jun 21, 2026 · Updated 15 times
Summary
This phase 2 trial is testing whether a 10-day course of the antibiotic metronidazole plus a chlorhexidine mouth rinse can lower the amount of bacteria living inside oral tumors. The study involves 30 adults with oral cancer who are scheduled for surgery. Researchers will compare bacteria levels before and after treatment, and track long-term outcomes like disease-free survival.
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Case Comprehensive Cancer Center, Cleveland Clinic Foundation
RECRUITINGCleveland, Ohio, 44195, United States
Contact
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
metronidazole and chlorhexidine mouth rinse
What this could lead to
If it works, this could point toward a way to lower bacteria inside oral tumors, potentially improving survival after surgery.
What could go wrong
This is a small, early-phase study with only 30 participants, so results may not apply broadly. The antibiotics may not reduce tumor bacteria enough to affect outcomes.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.