HEAD AND NECK CARCINOMA

This study is testing a new approach for people with certain head and neck cancers: using lower doses of radiation and chemotherapy, followed by surgery to remove any remaining cancer in the neck. The goal is to see if this gentler treatment can still control the cancer while red…

This study tests whether a short course of antibiotics (metronidazole) and mouthwash (chlorhexidine) can lower the amount of bacteria living inside oral cancer tumors. About 30 adults scheduled for oral cancer surgery will receive the treatment before their operation. Researchers…

This study tests a new combination of drugs and radiation for people whose head and neck cancer has returned after previous treatment. The goal is to find the safest dose and see how well the treatment works. About 30 participants will receive the drugs tislelizumab and pamiparib…

This study tests an experimental drug called VMD-928, taken as a pill, either alone or with another drug (pembrolizumab), in people with advanced solid tumors or lymphoma that have stopped responding to standard treatments. The goal is to find a safe dose and see if it can shrink…

This study tests a new vaccine designed to help the immune system fight HPV-positive oropharyngeal cancer. It is for 24 adults who have completed initial treatment and show no signs of cancer remaining. The vaccine targets HPV proteins to trigger a stronger immune response, and r…

This study is for people with head and neck cancer who cannot or choose not to receive standard treatments. It tests a new radiation method called PULSAR combined with advanced planning technology (HyperArc) to deliver higher, more targeted doses of radiation. The goal is to bett…

This study tests whether a heavy lifting strength training program can help head and neck cancer survivors regain muscle strength, reduce fatigue, and improve quality of life. About 60 adults who finished cancer treatment at least one year ago will be randomly assigned to either …

This study tests whether using virtual reality (VR) can help reduce depression, anxiety, pain, and stress in people with head and neck cancer who are getting radiation therapy, as well as their caregivers. About 40 patients and their caregivers will try either a 3D VR mindfulness…

This study tests whether giving cancer treatment at home is preferred over going to a clinic. It involves 27 adults with various cancers in the Florida Panhandle. The goal is to see if home care improves patient satisfaction and is safe.

This study tests whether custom 3D-printed oral stents can reduce mouth sores and blisters in head and neck cancer patients receiving radiation therapy. About 119 adults will be randomly assigned to get radiation with or without the stent. The goal is to improve comfort and quali…

This study tests a simple technique called TORT where patients stick out their tongue during radiation for head and neck cancer. The goal is to see if this position lowers radiation to the tongue and throat muscles, reducing painful side effects like trouble swallowing, mouth sor…

This study looks at whether giving fluoride varnish during regular cancer follow-up visits can help improve oral health for head and neck cancer patients who have had radiation and lack easy access to dental care. About 120 uninsured or underinsured adults will take part. Researc…

This study collects blood and tissue samples from 2000 people—some with cancer, some without—to create a blinded reference set. Researchers will use these samples to evaluate how well new blood tests can detect many types of cancer early. The goal is to improve the accuracy of mu…

This study aims to find biological markers (biomarkers) that show up in the blood, tissue, or saliva when a person has HPV-related throat cancer, and disappear after successful treatment. Researchers will collect samples from 560 adults with or without the cancer to compare. The …

This study is gathering information on side effects from proton therapy in 5,000 adults with various cancers. Researchers will collect detailed treatment and toxicity data to better understand and predict short- and long-term side effects. The goal is to improve future patient ca…

This study tests a new program called Financial Compass that helps head and neck cancer patients deal with money problems caused by their illness. About 50 patients who are struggling financially will either get the program or usual care. The goal is to see if the program is prac…

This study aims to learn more about head and neck cancer by looking at cells and biological markers that may explain why some cancers grow or spread aggressively. Researchers will collect samples from 50 newly diagnosed patients who have not yet received any treatment. No new tre…

This study aims to learn more about cancer genes in people from different ethnic backgrounds. Researchers will test 1,800 adults with various solid tumors to see how common certain gene changes are. The goal is to improve cancer risk assessment and tailor screening for these popu…