OPIOID USE

This study compares two ways to help people on probation or parole who have opioid addiction. One group starts taking the medication buprenorphine right away at the parole office, while the other gets the usual referral to a community clinic. Researchers want to see if starting m…

This study aims to find the best way to provide HIV prevention medication and hepatitis C treatment to people who inject drugs. It compares two approaches: getting care directly at a drug treatment or needle exchange site versus being referred to a specialist clinic. Researchers …

This study is testing whether having a trained peer supporter helps people with HIV get better care for mental health or substance use problems. About 405 participants at a Johns Hopkins clinic were randomly assigned to either receive this peer support or continue with their usua…

This study is testing a special discharge plan to help patients who were injured and given opioid painkillers. The plan includes a medication schedule, a follow-up doctor's appointment, and better communication between hospital and family doctors. Researchers want to see if this …

This study is testing a new type of court, called an Opioid Court, designed to quickly connect people arrested with opioid use to treatment and medication. It aims to see if this system works better than standard drug courts at helping people stay in treatment, avoid relapse, and…

This study tests a program called TIARAS, which combines writing exercises with a reward system, to see if it helps women who inject drugs stay on their HIV prevention pills or shots (PrEP). Over 200 women will be randomly assigned to write about past trauma or neutral topics whi…

This study is testing whether giving patients a special bag and instructions helps them safely destroy leftover opioid pain pills after hip or knee replacement surgery. Researchers want to see if this approach prevents unused pills from being stored or misused at home. About 163 …

This study is testing whether a specific type of nerve block, given before thyroid surgery, can help reduce pain, nausea, and the need for opioid painkillers afterward. It involves 74 adults having thyroid surgery, who are randomly assigned to receive either the real nerve block …

This study is testing whether a combination of non-opioid pain medications can effectively manage pain after a laparoscopic hysterectomy, with the goal of reducing or eliminating the need for opioid prescriptions. Researchers are comparing this approach to standard opioid prescri…

This study compares two approaches to managing pain after robotic prostate cancer surgery. One group receives standard opioid pain medication, while the other receives a combination of non-opioid drugs like ketamine, ketorolac, and acetaminophen. Researchers want to see if the op…

This study is testing whether a testosterone gel can help reduce pain and improve daily life for women over 60 who have chronic back pain and are using opioid painkillers. Researchers will compare the gel to a placebo (inactive substance) over three months to see if it helps with…

This large study aims to give doctors better evidence for managing pain after surgery. It directly compares a combination of common, non-prescription pain relievers (like ibuprofen and acetaminophen) against a standard prescription opioid. The research involves over 1,800 adults …

This study aimed to test if a special pain-blocking injection given during surgery could help patients use fewer opioid painkillers afterward. It focused on people having weight loss surgery or other minimally invasive stomach procedures. The trial planned to compare two differen…

This study aimed to see if giving a single dose of methadone during breast reconstruction surgery could provide longer-lasting pain relief. The goal was to reduce the total amount of opioid painkillers patients need after their operation, which could lower the risk of side effect…

This study uses a special brain scan (PET/CT) to measure inflammation in the brains of four groups of people: those with HIV, those with opioid use disorder, those with both conditions, and healthy individuals. The goal is to understand how these conditions, alone or combined, af…

The goal of this pilot study is to describe and compare Ultrasound-Guided Erector Spinae Plane (ESP) Blocks using Exparel® (bupivacaine liposome injectable suspension) to Marcaine® (bupivacaine hydrochloride) for pain management and outcomes after cardiac surgeries.