OPIOID USE

This study tests whether a smartphone app can help people who are already on methadone treatment reduce their use of opioids and cocaine. About 240 adults who use both drugs will either get standard methadone care or also use an app that rewards them with money for drug-free test…

This study tests whether giving a short-term buprenorphine treatment (called a bridge) to people on probation or parole with opioid use disorder helps them start and stay in community-based treatment. About 320 adults in Baltimore will either receive the bridge treatment or a ref…

This study looks at the best way to provide HIV prevention medicine (PrEP) and hepatitis C treatment to people who inject drugs. About 446 participants will either get all their care at one location or be referred to a specialist elsewhere. The goal is to see which approach leads…

This study looks at whether having a trained peer case manager can help people with HIV who also have mental health or substance use problems get the care they need. About 405 adults from an HIV clinic will be randomly assigned to either usual care or extra support from a peer. T…

This study tests a program called TIARAS for women who inject drugs and are already taking PrEP to prevent HIV. Participants are randomly assigned to either write about a past trauma or write about neutral topics, and both groups also receive support to reduce drug use. The goal …

This study looks at whether giving fewer opioid pain pills after laparoscopic hysterectomy still keeps pain under control. About 120 adults having this surgery for non-cancer reasons will be randomly assigned to get either a standard or a reduced opioid prescription. The goal is …

This study tests whether a nerve block (an injection near the neck nerves) plus local anesthetic can lower pain, nausea, and the need for strong painkillers after thyroid surgery. About 74 adults having part or all of their thyroid removed will be randomly assigned to get either …

This study compares two pain control methods after robotic prostate removal: one using opioids and one using only non-opioid medicines like ketamine, ketorolac, and acetaminophen. About 100 men aged 40-75 with prostate cancer will participate. The goal is to see if the opioid-fre…

This study aimed to see if a nerve block (TAP block) given during stomach surgery could lower the amount of strong painkillers (opioids) patients need afterward. It compared two numbing medicines, Bupivacaine and Exparel. However, the study was withdrawn before any participants w…

This study tests a Pain and Coordination Plan (PAC-plan) for people who have had accidental injuries and are taking opioids after surgery. The plan includes guidance on stopping opioids, a follow-up doctor visit, and better teamwork between hospital and primary care. Researchers …

This study compares over-the-counter pain relievers to prescription opioids for managing pain after wisdom tooth removal. About 1,800 people will rate their pain and satisfaction over a week. The goal is to see if non-opioid options work just as well, which could help reduce opio…

This study tests whether a nerve block given before heart surgery can help manage pain and reduce the need for strong painkillers like opioids. About 150 adults having certain heart surgeries will be randomly assigned to receive one of two types of numbing medicine. The goal is t…

This study uses a special imaging scan (PET/CT) and a radioactive tracer to measure inflammation in the brain. Researchers will compare four groups: people with HIV, people with opioid use disorder, people with both, and healthy volunteers. The goal is to understand how these con…

This study follows about 163 adults who had knee or hip replacement surgery and were sent home with opioid pain pills. Researchers teach patients how to safely store and destroy unused pills, then check in 6-8 weeks later to see what they did with them. The goal is to learn how w…

This study looks at how to better connect people in the court system with medication for opioid use disorder. Researchers will test strategies to help courts quickly screen and link defendants to treatment. The goal is to reduce overdose deaths, drug use, and repeat offenses. Ove…

This study aimed to create a mobile app to teach people how to safely use, store, and throw away opioid pain medications. Researchers planned to test the app with patients who had a prescription for opioids, but the study was withdrawn before any participants were enrolled. No re…

This study planned to test whether giving methadone during breast reconstruction surgery could reduce the need for other painkillers afterward. It was designed for women having breast reconstruction after mastectomy. However, the study was withdrawn before enrolling any participa…