OBESITY, MORBID

This study looks at people who had a gastric bypass but later regained weight or didn't lose enough. It compares two different ways to do a second surgery (distal gastric bypass) to see which works better for weight loss and has fewer side effects like diarrhea. About 150 adults …

This study tests whether adding essential amino acids to a low-calorie, low-protein diet helps people with severe obesity lose more weight and maintain muscle mass. Sixty adults aged 45-65 with a BMI over 35 will be randomly assigned to receive either the amino acid supplement or…

This study tests a new, less invasive procedure called PSAM that cuts some stomach muscles to slow down how fast food leaves the stomach, which may help people feel full longer and lose weight. It is for adults aged 18-70 with a BMI over 35 who are eligible for weight loss proced…

This study looks at people who had a sleeve gastrectomy but didn't lose enough weight or regained it. It compares two follow-up surgeries: a newer, simpler one called SADI-S and a standard one called DS. The goal is to see if SADI-S works just as well for weight loss but with few…

This study looks at whether giving noninvasive breathing support right after removing the breathing tube can lower the chance that severely obese patients will need the tube put back in. About 250 adults with a BMI of 40 or higher who have been on a ventilator for at least 24 hou…

This study looks at whether limiting eating to a specific time window each day (time-restricted eating) is safe and doable for pregnant women with severe obesity. Researchers will enroll 60 women in their second and third trimesters to see if this approach helps control weight an…

This study compares two types of weight-loss surgery in 220 adults with severe obesity. One surgery is a sleeve gastrectomy (stomach reduction), the other adds an intestinal bypass. Researchers will measure weight loss, acid reflux, and other health changes over time. Participant…

This study compares a new, gentler surgical technique called low impact laparoscopy (using lower gas pressure and smaller cuts) to standard laparoscopy for people having weight-loss surgery (sleeve gastrectomy). The goal is to see if the gentler method reduces post-surgery pain a…

This study compares two methods of calculating propofol (anesthesia) doses for obese patients undergoing surgery. Researchers want to see if using adjusted body weight instead of total body weight leads to safer and more precise anesthesia delivery. The trial involves 46 obese ad…

This study looks at how full people feel after two types of weight-loss procedures: sleeve gastrectomy (removing part of the stomach) and a stitch procedure (OverStitch) for those who regained weight after earlier surgery. Researchers will ask 60 adults with severe obesity to dri…

This study is testing a new, ultra-thin endoscope that goes through the nose without sedation, making it easier and cheaper to examine the upper digestive tract in people with obesity. Researchers want to see if patients and doctors find it acceptable and comfortable. If successf…

This study aims to see if using a special tube to measure pressure inside the chest can help doctors set breathing machines better for severely obese patients with serious lung injury. About 40 adults with a BMI over 40 and moderate to severe ARDS will take part. The goal is to c…

This observational study looks at the bacteria in dental plaque of 170 people with obesity (BMI 30+) who are scheduled for bariatric surgery. Researchers want to see if the types and amounts of mouth bacteria differ between those with obesity (BMI 30-35) and those with morbid obe…

This study looks at how losing a lot of weight and keeping it off changes the way the body breaks down fat in response to insulin. Researchers will measure fat tissue inflammation and insulin's ability to control fat release in 30 people before and after bariatric surgery. The go…

This study looks at how inflammation in fat tissue is connected to fat buildup in the liver and insulin resistance in people with severe obesity. Researchers will measure liver stiffness and markers of inflammation in 60 adults who are having gastric bypass surgery. The goal is t…