OBESITY, MORBID

This study looks at whether weight-loss surgery (gastric bypass) is safer and more effective than standard treatments like diet and exercise for teens aged 13 to 18 with severe obesity. About 120 participants will be followed for up to 10 years to measure weight loss, quality of …

This study compares a new esophageal stent (Luso-Cor) with standard stents and vacuum therapy for closing leaks that can happen after weight-loss or cancer surgery on the stomach or esophagus. About 180 adults who develop these leaks will be enrolled. The goal is to see which met…

This study tests a brain implant that sends electrical pulses to reduce loss of control eating in people with severe obesity. Six adults who have not been helped by other treatments will try it. The main goal is to check safety and see if it cuts down on binge episodes.

This study compares two approaches to help rural adults with obesity lose weight. One group meets one-on-one with their doctor every three months. The other joins a group lifestyle program over Zoom plus quarterly team meetings with their doctor and a lifestyle coach. Researchers…

This study tests a procedure called endoscopic sleeve gastroplasty (ESG) in 10 obese teenagers aged 12-17. Instead of surgery, doctors use a flexible tube to reduce stomach size, helping with weight loss. The goal is to see if it's safe and helps teens lose weight and improve hea…

This study compares two types of weight-loss surgery (standard bypass vs. a simpler single-loop bypass) in people who have already had a partial stomach removal (parietal gastrectomy) but still have obesity or have regained weight. The goal is to see if the simpler surgery causes…

This study tests a remote, 8-week positive psychology program for people who had bariatric surgery 1-3 years ago and their romantic partners. The goal is to see if the program improves mood, resilience, relationship satisfaction, and healthy behaviors. About 80 couples will be ra…

This study looks at how changing the length of the small intestine during gastric bypass surgery affects metabolism and inflammation in people with severe obesity. Researchers will measure glucose tolerance and other metabolic markers before and 6-8 months after surgery in 65 par…

This study collects blood, urine, and tissue samples from 500 adults with obesity to help researchers learn why people gain or lose weight, and why some regain weight after treatment. Participants must be over 18 and have a BMI of 30 or higher. The samples will be stored for up t…

This study tests whether a green dye, injected during weight-loss surgery, helps surgeons see blood flow at the new stomach connection. About 300 adults having Roux-en-Y gastric bypass will take part. The goal is to see if better blood flow checks can lower the risk of ulcers, le…

This study will follow 5,000 adults who have had an endoscopic procedure for weight loss or to fix a previous weight-loss surgery. Researchers will track changes in weight, blood pressure, diabetes, and cholesterol for up to 10 years. The goal is to learn how well these procedure…

This study looks at whether liraglutide (Saxenda®), a drug used for weight loss, can increase a brain-health marker called BDNF in people with multiple sclerosis, long-COVID, or leukemia (in remission) who also have obesity and memory or thinking problems. About 30 participants w…

This study looks back at the records of 8,000 people who had weight-loss (bariatric) surgery for severe obesity. Researchers want to learn how different surgeries affect weight loss, safety, and health problems linked to obesity. The goal is to use this information to improve car…

This study looks at how weight loss surgery (bariatric surgery) might change memory and thinking skills in people with obesity and cognitive decline. Researchers will test memory and thinking before and after surgery in up to 9,500 participants. The goal is to understand if losin…