NON-HODGKIN LYMPHOMA

This study tested a personalized geriatric optimization plan (GO!) in 30 patients over 60 receiving a stem cell transplant for blood cancers or bone marrow failure. The plan included tailored changes to diet, sleep, activity, and medications. The goal was to see if these changes …

This study tested whether giving focused radiation to leftover cancer spots can help people with non-Hodgkin lymphoma who did not fully respond to CAR-T cell therapy. Fourteen adults with aggressive lymphoma received radiation to those remaining areas. The goal was to see if this…

This early-stage study tested a new drug called JNJ-64619178 in 114 people with advanced cancers, including lymphoma and solid tumors. The main goal was to find the safest dose and check for side effects. The drug works by blocking a protein that helps cancer cells grow.

This study tested a personalized cell therapy called tisagenlecleucel (a CAR-T treatment) against usual treatments for adults with a fast-growing type of blood cancer (aggressive B-cell Non-Hodgkin Lymphoma) that did not respond to or came back after initial chemotherapy. 330 par…

This early-phase study tested a new drug (BMS-986345) combined with an existing drug (duvelisib) in 14 people with blood cancers like lymphoma, myeloma, and leukemia. The main goal was to find a safe dose and check for side effects. Results help guide future research, but this is…

This early-phase study tested a new approach for people with advanced B-cell non-Hodgkin lymphoma or chronic lymphocytic leukemia (CLL) that had returned or not responded to standard treatments. Researchers took patients' own immune cells (T cells) and added a special receptor (a…

This study tested a two-step stem cell transplant for people with high-risk blood cancers like leukemia and lymphoma. First, patients got low-dose chemotherapy and radiation to prepare the body. Then, they received donor immune cells followed by donor stem cells to help destroy c…

This early-phase study tested a new drug called WTX-330 in 25 adults with advanced solid tumors or lymphoma that had stopped responding to standard treatments. The main goals were to check safety, find the right dose, and see if the drug shrinks tumors. The study is now complete,…

This study tested whether adding anakinra (a drug used for arthritis) to standard CAR-T cell therapy could prevent serious brain and nerve side effects in people with hard-to-treat non-Hodgkin lymphoma. Fifteen participants received both treatments. The goal was to see if the com…

This early-stage study tested a new drug called odronextamab (REGN1979) in 200 adults with B-cell blood cancers like non-Hodgkin lymphoma and chronic lymphocytic leukemia that had stopped responding to standard treatments. The goal was to check the drug's safety and find the righ…

This study tested a new treatment called AB-101, made from natural killer (NK) cells, for people with a type of blood cancer called non-Hodgkin lymphoma that had come back or stopped responding to other treatments. The treatment was given alone or combined with other drugs. The g…

This study tested a combination of three targeted antibodies (mosunetuzumab, polatuzumab vedotin, and obinutuzumab) in 42 people with untreated slow-growing B-cell non-Hodgkin lymphoma. The goal was to see how many patients achieve a complete response (no cancer detectable). The …

This study tested a three-drug combination (VIP152, venetoclax, and prednisone) in 8 adults with aggressive non-Hodgkin lymphomas that had not responded to or returned after prior treatment. The main goals were to check safety and find the best dose. Participants took pills at ho…

This study looked at whether giving vitamin D supplements to people with newly diagnosed non-Hodgkin lymphoma or chronic lymphocytic leukemia who have low vitamin D levels could improve their outcomes. About 197 participants received either a low or high dose of vitamin D alongsi…

This small pilot study tested whether an 8-week home exercise program guided by a trainer over video calls is practical and helpful for lymphoma survivors. The goal was to see if this approach could improve heart health in survivors who face a higher risk of cardiovascular proble…

This study aimed to find blood-based markers that could predict how well patients with advanced lung cancer, lymphoma, or urologic cancers respond to immunotherapy. Researchers collected blood samples from 135 patients before and during treatment to track immune system changes. T…

This study looked at over 1,700 people with blood cancers or disorders who needed a bone marrow transplant. Researchers compared two strategies: first searching for a matched unrelated donor and then an alternative if needed, versus going straight to an alternative donor. The goa…

This study tested a computer tool that helps doctors and cancer survivors discuss heart health during follow-up visits. About 645 survivors of breast, prostate, colorectal, endometrial, and lymphoma cancers took part. The goal was to see if the tool leads to more conversations ab…