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New cocktail targets tough lymphomas

NCT ID NCT05371054

First seen Dec 12, 2025 · Last updated Jun 18, 2026 · Updated 23 times

Summary

This early-phase study tested a combination of three drugs (VIP152, venetoclax, and prednisone) in 8 adults with aggressive non-Hodgkin lymphomas that had returned or not responded to prior treatments. The main goals were to check safety and find the best dose, while also measuring how many patients had their tumors shrink completely. Participants took pills at home and received IV infusions at the clinic in 21-day cycles for up to 24 cycles, with follow-up for up to 5 years.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • National Institutes of Health Clinical Center

    Bethesda, Maryland, 20892, United States

Conditions

The condition(s) this trial relates to.

adult T-cell leukemia/lymphoma ALK-negative anaplastic large cell lymphoma ALK-positive anaplastic large cell lymphoma angioimmunoblastic T-cell lymphoma diffuse large B-cell lymphoma hematopoietic and lymphoid system neoplasm high grade B-cell lymphoma lymphoid neoplasm lymphoma Nodal T-follicular helper cell lymphoma, follicular type non-Hodgkin lymphoma peripheral T-cell lymphoma, not otherwise specified

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.