NAFLD

This study looks at whether adding two different exercise programs to a Mediterranean diet can lower inflammation better than diet alone in adults aged 18-65 with obesity and non-alcoholic fatty liver disease. About 90 participants will be assigned to diet only or diet plus one o…

This study aims to find the most effective amount of exercise to reduce liver fat in people with NASH, a serious liver disease. Researchers will compare different exercise doses in 45 sedentary adults aged 18-69 with NASH and early-stage liver scarring. The goal is to provide cle…

This study tests whether nicotinamide (a form of vitamin B3) can stop or reverse liver scarring in people with fatty liver disease and obesity. About 30 adults will take either nicotinamide or a placebo daily for one year. Researchers will measure liver stiffness and fat to see i…

This early-stage study tests whether bicalutamide, a drug that blocks male hormones, can improve liver health in women aged 18-42 who have both polycystic ovary syndrome (PCOS) and nonalcoholic fatty liver disease (NAFLD). About 50 participants will receive either bicalutamide or…

This study is testing a new, portable device called LiverScope that uses magnetic fields to check the liver for disease, similar to an MRI but smaller and easier to use. Researchers want to see if LiverScope gives the same results as a standard MRI. About 26 adults with a type of…

This study compares two step-by-step approaches to diagnose advanced liver fibrosis in people with NAFLD (fatty liver disease). Both methods start with a simple blood test, then use a more advanced test only if needed, aiming to avoid invasive liver biopsies. About 1,045 particip…

This study tests a new care pathway to help primary care doctors at the VA better identify and treat non-alcoholic fatty liver disease (NAFLD) in Veterans. The program automatically flags at-risk patients and educates care teams. Researchers will compare this approach to usual ca…

This study looks at whether blocking two specific gene regulators in the liver can protect against nonalcoholic fatty liver disease (NAFLD). Researchers will test this in mice, analyze human genetic data, and use lab-grown liver models. The goal is to find new treatment targets f…

This study looks at why people born with low birth weight have a higher chance of developing fatty liver disease (NAFLD). Researchers will put 8 adults with NAFLD on a 4-week low-calorie diet to see if it reduces liver fat and improves health. The goal is to understand how the bo…

This study uses tiny, lab-grown liver models (organoids) made from patient cells to understand how a specific gene variant (I148M of PNPLA3) contributes to non-alcoholic steatohepatitis (NASH), a serious fatty liver disease. Researchers will expose these mini-livers to fatty acid…

This study looks at how genetic factors influence the risk of liver damage and heart problems in people with fatty liver disease. Researchers will enroll 2,500 blood donors aged 40-65 who are overweight or have related conditions like high blood sugar or high cholesterol. The goa…

This study looks at how androgens (a type of sex hormone) might affect fatty liver disease in young women. Researchers will compare changes in liver fat and stiffness over time in 150 women with and without PCOS. The goal is to understand the connection, not to test a treatment.