NAFLD

This study tested whether a combination of two drugs, dasatinib and quercetin, can reduce liver scarring in people with non-alcoholic fatty liver disease (NAFLD) and fibrosis. Thirty adults with biopsy-confirmed liver scarring took either the drug combo or a placebo in cycles ove…

This study tested an experimental drug called efinopegdutide in 381 adults with non-alcoholic steatohepatitis (NASH), a serious form of fatty liver disease. The main goal was to see if the drug could help the liver heal (resolve NASH) without making scarring worse. Participants r…

This study tested whether a natural plant compound called phytosterol can help people with non-alcoholic fatty liver disease (NAFLD). 27 adults took the supplement for 3 months. Researchers measured changes in liver enzymes, cholesterol, insulin, and inflammation. The goal was to…

This pilot study tested a drug called ibutamoren in 12 adults with nonalcoholic fatty liver disease (NAFLD). The goal was to see if it could lower fat in the liver. Participants took the drug for 6 months, and researchers measured liver fat using special MRI scans. The study was …

This Phase 2 trial tested a drug called DD01 in 67 overweight or obese adults with a type of fatty liver disease (MASLD/MASH). The goal was to see if DD01 could safely reduce liver fat by at least 30% over 48 weeks compared to a placebo. The study is completed, and results will s…

This phase 2 trial tested the drug elobixibat in 47 adults with nonalcoholic fatty liver disease (NAFLD) or its more severe form, NASH. The study compared elobixibat to a placebo to see if it could lower LDL cholesterol and improve liver health over 16 weeks. The trial is now com…

This study tested two versions of a low-calorie Mediterranean diet, each with different carb and fat levels, combined with moderate aerobic exercise in 36 adults with obesity and fatty liver disease (NAFLD). The goal was to see if one diet plan worked better than the other at red…

This study looked at 60 teenage girls with PCOS, obesity, and fatty liver disease. Half received the drug semaglutide, and the other half followed a special diet for 12 weeks. The goal was to see which approach better reduced liver fat and improved how the body uses insulin.

This study looked at whether adding tomatoes to the diet can improve liver health, gut function, and blood sugar in people with non-alcoholic fatty liver disease (NAFLD). 80 adults with NAFLD and a BMI of 30 or less followed a tomato-enriched diet for 6 weeks. Researchers measure…

This study tested two blood tests, eLIFT and FibroMeter, to see how well they detect advanced liver fibrosis in 722 adults with type 2 diabetes. The goal was to find a non-invasive alternative to liver biopsy or FibroScan. Researchers compared the blood test results to standard m…

This completed study looked at the economic burden of non-alcoholic fatty liver disease (NAFLD) in 73 adults in Flanders, Belgium. Researchers measured healthcare costs, patient expenses, and quality of life using questionnaires. The goal was to understand the financial impact of…

This study tested new MRI and MRE techniques that let children breathe normally during scans, instead of holding their breath. The goal was to measure liver fat and stiffness more comfortably and accurately in kids with fatty liver disease. 135 children aged 6-17 took part, and t…

This study looked at how people with chronic liver disease (like hepatitis B, C, or fatty liver) respond to COVID-19 vaccines. About 233 adults had three visits over a year to check their immune response and see if they got COVID-19. The goal was to understand if liver disease af…

This study looked at how the hormone glucagon affects the liver's ability to break down proteins and fats in people with obesity, type 2 diabetes, and fatty liver disease. Researchers wanted to understand if the body becomes resistant to glucagon in these conditions. A total of 2…

This study looked at how common and severe fatty liver disease is in people with type 2 diabetes. Researchers used advanced MRI scans to measure liver fat, inflammation, and scarring. 317 patients were checked twice, three years apart, to see how the disease changes over time. Th…

This study looked at 1005 people with non-alcoholic fatty liver disease (NAFLD) to find better ways to check liver damage without using a needle biopsy. Researchers tested blood tests and special ultrasound devices to see how well they can spot serious liver scarring. The goal is…