Mini-livers reveal secrets of fatty liver disease gene
NCT ID NCT06856252
First seen Nov 20, 2025 · Last updated May 19, 2026 · Updated 21 times
Summary
This study uses tiny, lab-grown liver models (called organoids) made from patient cells to understand how a specific gene variant (PNPLA3 I148M) contributes to non-alcoholic steatohepatitis (NASH), a serious form of fatty liver disease. Researchers will expose these mini-livers to fatty acids, fructose, and cholesterol to mimic the disease and look for new biomarkers. The goal is to better understand the disease process, not to test a treatment. About 60 adults having liver procedures will provide tissue samples.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico - Istituto di Ricovero e Cura a Carattere Scientifico di natura pubblica
RECRUITINGMilan, Milano, 20122, Italy
Contact Phone: •••-•••-•••• Email: •••••@•••••
Conditions
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