NAFLD

This early-stage trial tests whether bicalutamide, a drug that blocks male hormones, can reduce liver fat and stiffness in women with PCOS and nonalcoholic fatty liver disease (NAFLD). About 50 women aged 18-42 will receive either the drug or a placebo for a short time. The goal …

This study tests whether nicotinamide (a form of vitamin B3) can stop or reverse liver scarring in people with fatty liver disease and obesity. Thirty adults with liver fibrosis will take either nicotinamide or a placebo daily for one year. Researchers will measure changes in liv…

This study looks at how much exercise works best to lower liver fat in people with nonalcoholic fatty liver disease (NAFLD) and its more serious form, NASH. There is no approved drug for this condition, so exercise is a key treatment. The trial will enroll 45 sedentary adults age…

This study tests if a low dose of digoxin, a drug currently used for heart conditions, can help people with NASH (a severe type of fatty liver disease). About 144 adults with NASH and liver scarring will take oral digoxin for a period. The goal is to see if the drug can reverse t…

This study looks at whether adding different exercise programs to a Mediterranean diet can lower inflammation better than diet alone in adults aged 18-65 with obesity and non-alcoholic fatty liver disease (NAFLD). About 90 participants will be assigned to diet only, diet plus one…

This study compares two step-by-step strategies to diagnose advanced liver fibrosis in people with NAFLD (fatty liver disease). Both strategies start with a simple blood test, then use a more advanced test only if needed, to avoid invasive liver biopsies. About 1,045 participants…

This study is testing a new, portable device called LiverScope that uses MRI-like technology to check for liver disease without needles or surgery. Researchers want to see if it works as well as standard MRI scans. About 26 adults with fatty liver disease will have one visit that…

This study tests a new care pathway designed to help primary care doctors at VA clinics better identify and treat Veterans with non-alcoholic fatty liver disease (NAFLD), a common but often undiagnosed liver condition linked to obesity and diabetes. The pathway automatically flag…

This study looks at how androgens (a type of sex hormone) might influence fatty liver disease in young women. Researchers will compare women with and without PCOS, a condition linked to high androgen levels and liver fat. The goal is to understand how liver health changes over ti…

This study looks at why people born with low birth weight are more likely to develop fatty liver disease (NAFLD). Researchers will put 8 adults with NAFLD on a 4-week low-calorie diet to see if it reduces liver fat. The goal is to understand how body fat storage affects liver hea…

This study looks at how genes influence fat buildup in the liver and whether that fat raises the risk of liver damage and heart problems. Researchers will study 2500 blood donors aged 40-65 who are overweight or have related health issues. The goal is to use genetic information t…

This study uses tiny, lab-grown liver models (called organoids) made from patient cells to understand how a specific gene variant (PNPLA3 I148M) contributes to non-alcoholic steatohepatitis (NASH), a serious form of fatty liver disease. Researchers will expose these mini-livers t…

This study looks at whether blocking two proteins, SUV420H1 and SUV420H2, in liver cells can protect against nonalcoholic fatty liver disease (NAFLD). Researchers will test this in mice, analyze human genetic data, and try a new gene-silencing approach in lab-grown human liver ti…