MENTAL DISORDERS

This study tests whether a sedative called dexmedetomidine can prevent long-term memory and thinking problems that often occur after heart surgery. Researchers will enroll 2,400 adults aged 60 and older who are having bypass or valve surgery. Participants will receive either dexm…

This study tests whether adding a group-based stabilization and skill-training program to regular individual therapy helps people with long-lasting post-traumatic stress recover better. About 160 adults already receiving outpatient mental health care will take part. Half will get…

This study tests two approaches—mindfulness training and patient-centered pain management visits—to help adults with chronic pain who have been taking opioids for at least three months. The goal is to reduce pain, improve quality of life, and lower the risk of opioid misuse. Abou…

This study tests whether a new drug called (2R,6R)-HNK can quickly improve symptoms in adults with major depression that hasn't responded to other treatments. About 50 participants will receive four infusions of the drug and four of a placebo over several weeks, with their mood a…

This study tests whether adding ear acupressure (small seeds taped to ear points) to standard nicotine patches can better reduce cravings, withdrawal symptoms, and anxiety in psychiatric patients who must stop smoking while in the hospital. About 60 adults aged 18-65 will be rand…

This study looks at how the brain's structure and genes in the blood are linked in people with schizophrenia. About 1,900 participants, including healthy volunteers, will have brain scans and blood tests over one year. The goal is to learn more about the disease, not to test a ne…

This study looks at how the brain manages emotions when facing a threat. Researchers will record brain activity and use mild electrical stimulation in people with epilepsy who already have electrodes implanted for medical reasons. The goal is to understand brain connections invol…

This study looks at brain activity in children with overactive bladder and daytime wetting compared to healthy children. Researchers will use brain scans to see if a nerve stimulation treatment changes how the brain controls the bladder. About 65 children will take part, and the …