MENTAL DISORDERS

This study tests whether donanemab can slow memory and thinking decline in people with early Alzheimer's disease. About 1,500 participants with mild symptoms and brain amyloid plaques will receive the drug or a placebo for up to 93 weeks. The main goal is to see if donanemab help…

This study compares a structured, clinician-led exercise program called Braining with advice to exercise on your own for people receiving psychiatric care. Over 12 weeks, participants attend up to three supervised exercise sessions per week. The goal is to see if Braining increas…

This study tests whether changing the dose schedule of donanemab can lower the risk of a brain swelling side effect called ARIA-E while still clearing amyloid plaques. About 1,175 adults with early symptomatic Alzheimer's will receive different dosing regimens over 91 weeks. The …

This study looks at whether Tai Chi, a gentle mind-body exercise, can improve chronic insomnia in breast cancer survivors. About 90 women who have finished cancer treatment and have had trouble sleeping for at least 6 months will participate. The goal is to see if Tai Chi helps t…

This study looks at a new computer tool that helps doctors know which patients are at high risk for an opioid overdose. The tool works inside the hospital's electronic health record system and sends an alert when a doctor prescribes an opioid. Researchers are checking if the tool…

This study aimed to see if a general form of group therapy, using skills common to all major therapies, could help adults with depression, anxiety, PTSD, or stress. It was designed for people 18 and older with self-reported distress, but excluded those with recent self-harm, suic…

This study looks at whether a team-based care model can help youth aged 14-17 with mental health and addiction issues get faster, better care. About 247 teens will be randomly assigned to either the new team approach or usual care at hospital clinics in Toronto. The goal is to se…