KIDNEY TRANSPLANT

This early-stage study tests whether injecting donor stem cells directly into the kidney's main artery is safe for people who have rejection after a kidney transplant. The stem cells are meant to reduce inflammation and treat the rejection. The study involves 12 adult kidney tran…

This study tests whether adding sodium thiosulfate to the fluid that keeps donor kidneys cold during transport can reduce the chance of delayed kidney function after transplant. About 120 adults receiving a deceased donor kidney will be randomly assigned to get the additive or st…

This study tests a treatment called VX-880 in 10 people who have both type 1 diabetes and a kidney transplant. The goal is to see if it can help them stop taking insulin while keeping their blood sugar under control. Participants will continue taking lifelong anti-rejection drugs…

This study tests a drug called sparsentan in 20 adults who have protein in their urine after a kidney transplant due to IgA nephropathy or FSGS. Participants take one pill daily for 36 weeks to see if it safely lowers protein levels and protects kidney function. The goal is to co…

This study tests if giving terlipressin during kidney transplant surgery helps maintain blood pressure better than standard drugs. About 150 adults with kidney failure will be randomly assigned to receive either terlipressin plus dobutamine or dobutamine alone. The goal is to see…

This study tests if a doctor-led counseling program, plus two smartphone apps, can help older adults (60+) who have had a liver or kidney transplant eat better and be more active. Sixty participants will first get lifestyle advice, then use the apps for 12 weeks. The goal is to s…

This study looks at 800 adult first-time kidney transplant recipients to see if a blood test can predict who is at higher risk for rejection. Six months after transplant, 300 eligible participants will be randomly assigned to switch from the standard drug tacrolimus to abatacept …

This study looks at whether empagliflozin, a drug used for diabetes and chronic kidney disease, is safe for people who have received a kidney transplant. About 264 veterans will take the drug to see if it causes side effects like infections or affects their transplant. The goal i…

This study tests a new treatment for people who get a kidney from a brother or sister. After the transplant, patients receive radiation and a drug, followed by an infusion of the donor's blood stem cells. The goal is to see if this helps the body accept the kidney so that patient…

This study tests if a single injection of Berinert into a donor kidney before transplant can improve kidney function one year later. It involves 180 adults on dialysis waiting for a deceased-donor kidney transplant. Half receive the drug, half receive a placebo, and neither the p…

This study involves 200 children aged 13-20 who are receiving a kidney transplant. Researchers are comparing a new combination of immunosuppressive drugs (belatacept and sirolimus) with the standard combination (tacrolimus and MMF) to see which better prevents the body from attac…

This study tests whether bone marrow stem cells are safe for people with chronic kidney disease, including those who have had a kidney transplant. About 75 adults will receive stem cells through a vein or directly into the kidney arteries. The goal is to monitor side effects, not…

This study tests a special jacket that keeps donated kidneys warm during transplant surgery. The goal is to see if the jacket is safe for different types of kidneys and patients. About 20 adults getting their first or second kidney transplant will take part. Researchers will watc…

This study tests if the drug ravulizumab can help transplanted kidneys start working sooner, reducing the need for dialysis after surgery. About 450 adults at high risk for delayed graft function will receive either the drug or a placebo. The main goal is to see how quickly patie…

This study tests a new approach using a patient's own modified immune cells (CAR T cells) to lower the risk of rejecting a donated kidney. It is for people with kidney failure who have been on the transplant waiting list for at least a year and have a very high chance of rejectin…

This study tests a new drug, leymovir, against the standard drug valganciclovir to prevent cytomegalovirus (CMV) infection in 290 Chinese kidney transplant recipients. Leymovir works differently and may cause fewer side effects like low white blood cell counts and kidney damage. …

This study explores whether artificial intelligence can create personalized stories to help children aged 5 to 12 who have received a kidney transplant. The stories are designed to address the emotional and social challenges these kids face. Researchers will ask 100 children and …

This study collects blood samples from 400 kidney transplant patients to help develop a non-invasive test that detects DNA from the donor kidney. The goal is to monitor the health of the transplanted organ without needing a biopsy. Participants must be 18 or older, have had a kid…

This study watches 80 people with advanced kidney disease who are waiting for a kidney transplant. Researchers will measure heart blood flow and function before and after the transplant to see if the new kidney helps the heart. The goal is to understand how kidney disease and inf…

This study tests a new, non-invasive MRI technique to monitor kidney function after a transplant. Instead of relying on blood tests or invasive biopsies, the MRI measures blood flow and oxygen levels in the kidney. The goal is to detect early signs of rejection or damage, potenti…

This study tests two new imaging methods—ultrasound localization microscopy and multispectral optoacoustic tomography—to check the health of kidney transplants without needing a biopsy. Ten adult kidney transplant patients who already need a biopsy will be scanned to see if these…

This study follows 30 adults who recently received a kidney transplant to track changes in their health over one year. Researchers will measure heart disease and stroke risk factors, such as blood pressure and cholesterol, along with physical fitness and other medical conditions.…

This study explores whether a special type of MRI, called manganese-enhanced MRI (MEMRI), can help detect early signs of heart and kidney problems in people with various kidney diseases, including acute kidney injury, chronic kidney disease, and kidney transplant. Researchers wil…

This study looks at why some kidney transplant patients develop blood sugar problems like diabetes. It focuses on the drug tacrolimus, which helps protect the new kidney but can harm insulin-producing cells. Researchers will track 120 patients in Poland to see how fast their bodi…

This study surveys 1000 kidney transplant recipients in France and the U.S. to understand their views on artificial intelligence in medicine, especially a system that predicts when a transplanted kidney might fail. Participants fill out an online questionnaire about their hopes a…

This study follows 200 kidney transplant patients in Scotland to see if certain biomarkers can help predict transplant rejection. Researchers will collect urine samples and track health outcomes during routine follow-up visits. The goal is to improve how doctors monitor and manag…

This study looks at the long-term health of children (16 and older) whose mothers had a solid organ transplant before pregnancy. Researchers want to see if these children have higher risks for heart or kidney problems, possibly due to the mother's anti-rejection medications. Abou…