HEMATOLOGIC MALIGNANCY

This early-phase trial tests a new type of immune therapy called CD70-CAR T cells in children and young adults up to age 21 with blood cancers that have come back or not responded to treatment. The therapy involves taking the patient's own immune cells, engineering them to recogn…

This study tests a special stem cell transplant for children and adults with blood cancers like leukemia. The transplant uses stem cells that have had certain immune cells removed to lower the risk of graft-versus-host disease, a serious complication. About 70 participants will r…

This study tests a new way to do a stem cell transplant for children with a hard-to-treat type of leukemia (ALL). Doctors will use special immune cells (CAR T cells) after the transplant to try to kill any remaining cancer cells. The goal is to see if this approach is safe and wo…

This early-stage study tests whether a new drug called ziftomenib is safe when combined with standard chemotherapy for people whose acute myeloid leukemia (AML) has come back or not responded to treatment. The study includes adults with specific genetic changes (NPM1 mutation or …

This study tests a new treatment made from specially engineered immune cells (T cells) donated by healthy people. The cells are designed to better recognize and kill cancer cells while lasting longer in the body. The trial includes 24 adults with blood cancers or solid tumors tha…

This early-phase trial is testing whether adding a patient's own blood stem cells to standard CAR T therapy is safe and doable for people with blood cancers that have come back or not responded to treatment. About 20 adults will receive their own stem cells 10 days after CAR T in…

This early-stage trial tests whether adding two drugs, decitabine and venetoclax, to a standard reduced-intensity stem cell transplant is safe for people with high-risk blood cancers like leukemia. The study involves 20 adults aged 18-75 who have a matched donor. The main goal is…

This early-phase study tests a new way to give immune cells (T-cells) after a stem cell transplant in children with high-risk blood cancers. The goal is to see if giving special memory T-cells early can help fight cancer while reducing dangerous side effects like graft-versus-hos…

This study tests two different pre-transplant conditioning plans combined with a single drug combination (cyclophosphamide and methotrexate) to prevent graft-versus-host disease (GVHD) in blood cancer patients receiving a stem cell transplant from a matched donor. About 82 adults…

This study looks at the best length of treatment with the drug maribavir for a hard-to-treat CMV infection that can happen after a stem cell transplant. About 218 adults who have already had a transplant and have this infection will be randomly assigned to different treatment dur…

This study is for people with blood cancers like leukemia who are getting chemotherapy or a stem cell transplant, which can cause very low white blood cell counts (neutropenia) for over a week. The goal is to see if the antibiotic eravacycline can prevent serious bacterial infect…

This study is for people living with HIV who also have a blood cancer that can be treated with a bone marrow transplant. Researchers want to see if a new mix of three drugs can safely prevent graft-versus-host disease, a common complication where donor cells attack the patient's …

This study is for people who have had a stem cell transplant for blood cancer and are at high risk of serious fungal infections. The standard preventive drug may not work well enough anymore. Researchers are testing a stronger drug, posaconazole, and checking its levels in the bl…

This study looks at the long-term safety and benefits of the drug pelabresib in people with blood cancers, solid tumors, or advanced cancers. It includes up to 50 adults who were in earlier pelabresib studies and are still benefiting from the drug. Some participants who received …

This early-phase study tests whether Darzalex Faspro can safely lower donor-specific antibodies (DSAs) in 8 adults with blood cancers or bone marrow failure who are at high risk of rejecting a stem cell transplant. The goal is to reduce DSA levels enough to allow the transplant t…

This early-phase study tests whether injecting specially grown immune cells (HTLP) after a cord blood transplant can help rebuild the immune system more quickly in adults with blood cancers. Ten participants will receive the injection and be monitored for side effects like graft-…

This study tests whether combining two oral drugs, pirtobrutinib and venetoclax, can control mantle cell lymphoma (MCL) in patients whose cancer has come back or hasn't responded to prior treatments. About 30 adults with confirmed MCL will take these pills to see how many achieve…

This study tests whether adding the drug belumosudil to standard care can better prevent graft-versus-host disease (GVHD) in adults with blood cancer who have had a stem cell transplant. About 46 participants will receive belumosudil along with their usual GVHD prevention medicin…

This study tests a stem cell transplant for people with blood cancers like leukemia or lymphoma. It uses a milder chemotherapy and radiation plan to prepare the body for a half-matched donor's stem cells. The goal is to see if this approach helps the new cells grow safely and con…

This early-stage trial tests whether adding abatacept to standard anti-rejection drugs can safely prevent graft-versus-host disease (GVHD) in 10 adults with blood cancers receiving a special type of stem cell transplant (omidubicel). Participants will receive the drug combination…

This study aims to create a blood test that can find many types of cancer at an early stage. Researchers will analyze DNA from blood samples of 6,000 people, including those with and without cancer, to train an artificial intelligence platform. The goal is to improve early detect…

This study tests a new program that brings blood transfusions to the homes of people with advanced blood cancers who are in hospice care. The goal is to see if this improves their quality of life, mood, and reduces hospital visits near the end of life. About 700 patients will tak…

This study tests whether a combination of a ketogenic diet supplement and online brain training can improve memory and thinking in blood cancer survivors. About 80 adults who have had a blood cancer and have mild to moderate thinking problems will be randomly assigned to either r…

This study tests a program called Nite2Day+ that uses mindfulness and sleep tips to help people with blood cancers sleep better and manage fatigue, stress, and pain. About 60 adults hospitalized for treatment will either get the program or standard care. The program includes a mo…

This study tests whether using a virtual reality (VR) headset during a bone marrow biopsy can lower pain and anxiety. About 160 adults with blood cancers will be randomly assigned to use VR or standard care. Researchers will compare pain scores right after the procedure and the n…

This study compares two oral medications—diosmin-hesperidin (a plant-based supplement) and loratadine (an allergy drug)—to prevent severe bone pain caused by G-CSF, a drug that boosts white blood cells in blood cancer patients. About 88 adults receiving G-CSF for leukemia, lympho…

This study explores whether a four-week online expressive writing workshop can improve mental wellness in young adults (ages 18-39) with blood cancer. Participants will attend the workshop and complete three surveys over 12 weeks to track changes in wellbeing and stress. The goal…

This study tests whether giving blood transfusions at home is practical and acceptable for cancer patients who need regular transfusions. About 30 adults with blood cancers or bone marrow failure will receive 1-5 blood product units at home. Researchers will track how often trans…

This study tests a program called BMT-CARE designed to improve the quality of life for people caring for a loved one undergoing a bone marrow transplant. Researchers will compare the well-being of 800 caregivers who receive the program versus those who get usual care. The goal is…

This study tests a new program called Sentinel that helps doctors provide extra comfort and support to patients getting a stem cell transplant. The program is designed to be part of regular care. The study will check if the program is practical and if patients like it. About 40 a…

This study looks at whether a 12-week home exercise program with remote coaching can help lymphoma survivors improve their heart and lung fitness and stay active after cancer treatment. About 80 adults who finished chemotherapy for lymphoma will either exercise at home with remot…

This study looks at whether adding a special palliative care program (called PEACE) to usual cancer care can improve quality of life for adults with blood cancers like lymphoma, leukemia, or multiple myeloma who are receiving cell therapy. About 90 participants will be randomly a…

This study looks at how the body processes venetoclax when the tablet is crushed and mixed into a liquid. It includes 30 children and young adults with blood cancers who already take venetoclax this way. The goal is to measure drug levels in the blood and spinal fluid to ensure t…

This study looks at whether CAR-T cell therapy, a new immune treatment for blood cancers, can cause early heart problems. Researchers will check heart function with ultrasound in 60 patients before and a few days after treatment. The goal is to find out how often heart issues hap…

This study looks at how metabolism in cancer and immune cells influences the bone marrow environment and treatment resistance in blood cancers like leukemia and myelofibrosis. Researchers will analyze samples from 350 participants to measure metabolites, lipids, and gene activity…

This study looks at whether blood cancer patients with a serious infection can safely stop antibiotics sooner if they are stable for 72 hours, instead of the usual 10-day course. About 172 adults will be randomly assigned to either a personalized short course or standard long cou…

This study tests a new communication tool called 'Let's Get REAL' that helps children and teens (ages 8-17) and their families talk together about stem cell transplant or cellular therapy decisions. The goal is to see if the tool is easy to use and helpful for families. About 60 …

This study looks at whether we can safely remove the "beta-lactam allergy" label from blood cancer patients who are not truly allergic. By doing so, doctors can use more effective antibiotics. The study will enroll 3,800 hospitalized adults with blood cancers and a reported aller…

This study looks at how a stem cell transplant changes a person's DNA and how that affects drug dosing. Researchers will collect blood, skin, hair, and other samples from 88 adults before and after transplant. The goal is to find the best way to test a patient's genes for safe an…

This study aims to find out if certain blood markers can predict how well cancer patients respond to immunotherapy. Researchers will collect blood samples from 1500 people with different types of cancer before and during treatment. Participants will be followed for up to 6 months…

This study follows 100 children and young adults who received CAR T cell therapy to understand short- and long-term side effects like infections, slow blood cell recovery, and nerve problems. Researchers will check participants at 3, 6, 12, and 24 months after treatment. The goal…

This study looks at blood samples from 50 people with blood cancers who are getting CAR T therapy. Researchers want to see how certain immune cells change over time and if those changes are linked to the cancer coming back or not responding. The goal is to learn more, not to test…

This study aims to understand how well the seasonal flu vaccine works in children with blood cancers like leukemia. Researchers will measure the immune response in up to 150 children at St. Jude Children's Research Hospital. The goal is to see if the vaccine triggers enough prote…