HEMATOLOGIC MALIGNANCY

This study tests a reduced-intensity stem cell transplant for people with blood cancers like leukemia or lymphoma. It uses a half-matched family donor and aims to help the body accept the new cells while controlling the cancer. 20 adults will take part to see if this approach imp…

This study tests a new treatment called CD70-CAR T cells for children and young adults up to age 21 with blood cancers like leukemia, lymphoma, or MDS that have come back or not responded to standard therapy. The treatment uses the patient's own immune cells, modified in a lab to…

This study tests two different pre-transplant chemotherapy plans combined with a single drug (cyclophosphamide) given after transplant to prevent graft-versus-host disease (GVHD), a common and serious complication. About 82 adults with blood cancers who have a matched donor will …

This study is testing whether giving blood transfusions at home is practical and okay for cancer patients who need transfusions often. About 30 adults with blood cancers or bone marrow problems will receive 1-5 units of blood products at home. Researchers will track how often tra…

This study is testing whether wearing a virtual reality headset during a bone marrow biopsy can help reduce pain and anxiety. About 160 adults with blood cancers will be randomly assigned to use VR or standard care. The goal is to see if a simple, non-drug distraction can make th…

This study is for children with blood cancer who are getting the seasonal flu vaccine. Researchers want to see how their immune system responds to the vaccine and how long that protection lasts. Up to 150 children will take part at St. Jude Children's Research Hospital. The goal …

This study aims to find out if certain immune markers in the blood can predict how well cancer patients respond to FDA-approved immunotherapy. Researchers will collect blood samples from 1500 participants before and during treatment and track their response for up to 6 months. Th…

This study looks at how the body processes venetoclax when the tablet is crushed and mixed into a liquid for children and young adults with blood cancers like leukemia or lymphoma. About 30 participants who already take venetoclax this way will have blood samples taken to measure…

This study is for adults getting a stem cell transplant for blood cancers like leukemia or lymphoma. It collects DNA from blood, skin, hair, and cheek cells before and after transplant to see how the donor's genes change drug processing. The goal is to find the best way to test a…

This study looks at why some blood cancers come back after CAR T therapy. Researchers will track immune cells in 50 patients over time to find patterns linked to relapse. The goal is to understand resistance, not to test a new treatment.

This study looks at whether CAR-T cell therapy, a new immune treatment for blood cancers, can cause early heart problems. Researchers will check heart function with ultrasound before and a few days after treatment in 60 patients. The goal is to find out how often heart issues hap…