HEMATOLOGIC MALIGNANCY

This study tests whether a blood test that measures CMV-specific immunity can help doctors decide how long to use the antiviral drug letermovir after a stem cell transplant. The goal is to prevent late-onset CMV infection, a common and serious complication. The trial involves 250…

This phase 2 trial tests whether adding the drug tocilizumab to a standard transplant regimen can prevent graft failure and graft-versus-host disease in people with blood cancers receiving a special type of bone marrow transplant. The study involves 21 participants and aims to re…

This study tests a new way to do stem cell transplants for 20 children with blood cancers or myelodysplasia who don't have a perfect donor match. Doctors remove certain immune cells from a parent's partially matched stem cells before transplant to help the new cells grow faster a…

This early-phase study tests whether giving healthy donor NK cells along with two medicines (vactosertib and IL-2) is safe and helps the cells stay active in people with advanced colorectal, stomach, esophageal, or blood cancers. The NK cells are meant to attack cancer, but the b…

This study tests a mobile app called CARE designed to support caregivers of people receiving a bone marrow transplant. The goal is to see if using the app improves the caregiver's quality of life and reduces stress. About 120 adult caregivers will participate, and their well-bein…

This study creates 3D organoids from bone marrow samples of 70 people with blood cancers to test how well different chemotherapy combinations kill cancer cells. The goal is to see if these lab models can predict which treatment works best for each patient, especially when the can…

This study follows about 178 people who previously received AvenCell's CAR-T cell therapy for blood cancers or prostate cancer. The goal is to monitor long-term safety, including delayed side effects like new cancers or autoimmune problems. Participants are not receiving new trea…

This study collects leftover tissue and blood samples from 1,200 adults with known or suspected cancer during their standard surgeries or biopsies. Researchers will compare cancerous and normal tissues to find differences that could lead to new treatments. No extra procedures are…

This study looks at whether older adults with cancer can use computer surveys (like on a tablet or computer) to answer health questions. Researchers want to see if these digital tools are easy to use, reliable, and give the same results as paper surveys. About 100 people aged 65 …

This study looks at how doctors and patients feel about a new approach to picking antibiotics for people with blood cancers who have a reported penicillin allergy. The goal is to understand what might make it easier or harder to use this approach in everyday hospital care. About …

This study follows about 150 people who previously received Caribou cell therapy for blood cancers like lymphoma or leukemia. Researchers will check for long-term side effects and overall survival for up to 15 years after treatment. No new treatment is given—this is just observat…

This study tests a program called PATH-C that uses positive psychology exercises to improve well-being, quality of life, and physical activity in caregivers of stem cell transplant patients. About 80 adult caregivers will be randomly assigned to the program or usual support. The …