GOUT

This early-stage trial tested a new drug called HEC93077 in 126 healthy Chinese volunteers and people with high uric acid (hyperuricemia), a condition that can lead to gout. The main goals were to check the drug's safety, how the body processes it, and whether food affects its ab…

This study tested a new drug called AR882 in 818 adults with gout. The goal was to see if AR882 lowers uric acid levels better than a placebo over 12 months. Participants took either a low or high dose of AR882 or a placebo pill. The main measure was how many people reached a saf…

This study tested a new medicine called tigulixostat in 354 adults with gout and high uric acid levels. The goal was to see if taking the drug for 6 months could safely lower uric acid below a target level. Participants received either one of three doses of tigulixostat or a plac…

This study tested a new medicine called LC350189 in 156 adults with gout and high uric acid. The goal was to see if the drug could safely lower uric acid levels over 12 weeks. Participants received one of three doses of the new drug, a placebo, or an active comparator. The main m…

This study tested a new medicine called ABP-671 for people with gout, a painful form of arthritis caused by high uric acid levels. About 300 adults took part to see if ABP-671 could safely lower uric acid below a target level. The drug was compared to a placebo and an older gout …

This study tested whether a gout medication (pegloticase) given every 4 weeks with methotrexate works as well as the standard every-2-week schedule for people with hard-to-control gout. About 262 adults with uncontrolled gout took part. The goal was to see if the less frequent do…

This phase 3 trial tested a new gout drug, epaminurad, against the standard treatment febuxostat in 612 adults with gout. The goal was to see which drug better lowers uric acid levels below 6 mg/dL. Participants took one of the two medications for several months, and researchers …

This study looked at whether giving the gout medication pegloticase over a shorter time is safe and works well for people with uncontrolled gout who are also taking methotrexate. About 191 adults took part. The main goal was to check for infusion reactions, and a key measure was …

This study tested a phone-based version of the Walk With Ease program for 267 adults with arthritis, gout, fibromyalgia, or lupus. Participants received coaching over the phone to help them walk more and manage symptoms. The goal was to see if this approach could reduce pain and …

This study looked at medical records from nearly 295,000 older adults with gout to see if two common gout medications, probenecid and allopurinol, affect the risk of developing Alzheimer's or other dementias. The goal was to find out if either drug could be repurposed to protect …

This study looked at whether people who donate a kidney have a higher chance of developing gout later in life. Researchers compared 50,000 living kidney donors to similar healthy people who did not donate. They used health records from three Canadian provinces to track gout diagn…

This study looked at 60 adults with gout who were starting medication to lower uric acid. Researchers compared two types of scans—ultrasound and DECT—to see how well they measured changes in urate crystal deposits over 24 months. The goal was to find out which imaging method work…

This study tested a new skin patch that measures uric acid levels in people with gout. Six participants wore the patch during a meal and for 7 days at home. The goal was to see if the patch is comfortable and can accurately track uric acid and other substances. This is an early t…

This study looked at 33 Polynesian adults from families with multiple gout cases to find genetic factors that increase gout risk. Researchers compared gout patients with their non-gouty relatives and used advanced CT scans to detect early crystal deposits. The goal is to better u…

This study aimed to find the genetic causes of certain inherited kidney diseases that run in families. Researchers studied 225 adults with chronic kidney failure and gout, looking for mutations in known genes and searching for new ones. The goal was to better understand these rar…

This study followed over 18,000 Taiwanese adults to see if a vegetarian diet is linked to a lower risk of chronic diseases like dementia, depression, heart disease, stroke, gout, cataracts, gallstones, and urinary tract infections. Researchers used health insurance records to tra…

This study looked at how common gout is in French Polynesia and what genetic factors might cause it. Over 1,000 adults from several islands took part. Researchers measured gout rates and searched for genetic links to better understand why Polynesians have higher rates of this pai…

This study looked at how often nursing home residents over 65 have joint complaints like pain or swelling. Researchers examined 100 residents, some with dementia and some without, to count tender or swollen joints. The goal was to better understand these issues in a group that is…