GOUT

This study tests a new medicine called PRX-115, given through a vein, to see if it can lower uric acid levels in adults with gout who haven't had success with standard pills. About 150 people will receive either PRX-115 (with or without methotrexate) or a placebo over 24 weeks. T…

This study looks at whether giving gout medication (febuxostat) right after an attack is better than waiting the usual 6 weeks. Gout is a painful joint condition caused by high uric acid. The goal is to see if early treatment reduces the number of days with gout symptoms. About 1…

This study tests a new drug called dotinurad for adults with gout who cannot take common medications or did not respond to other treatments. The goal is to see if dotinurad can safely lower uric acid levels over 24 weeks. About 90 participants will receive either the drug or a pl…

This study tests a new medicine called dotinurad to see if it lowers uric acid better than the standard drug allopurinol in adults with gout. About 500 people with frequent gout flares will take either dotinurad or allopurinol for 24 weeks. The main goal is to see how many reach …

This study looks at whether people with well-controlled gout (for 5 years or more) can take a lower dose of febuxostat or even stop it without their uric acid levels rising or symptoms coming back. About 59 adults will be split into three groups: one that reduces the dose, one th…

This early-stage study tests a new injectable drug called peguricase, given together with methotrexate, in 36 adults with gout that standard treatments fail to control. The main goals are to check safety, how the drug moves through the body, and to find the right dose for future …

This study looks at how long it takes for urate crystals in the joints of people with gout to completely dissolve when uric acid levels are kept very low. Researchers will use ultrasound to track crystal disappearance in 250 adults over time. The goal is to find out what factors …

This study tests a new gout drug, tigulixostat, against an existing one, febuxostat, in 600 Chinese adults with gout. The goal is to see which better lowers uric acid levels below a target threshold over 24 weeks, while also monitoring safety, gout attacks, and quality of life fo…

This study compares two common gout treatment strategies: one that aims to lower urate levels to a target, and another that treats symptoms as they occur. Researchers will track gout flares and quality of life over two years in 650 adults with gout. The goal is to find which appr…

This study tests a new way for people with gout to manage their condition. Participants will either use a smartphone app to check their own urate levels and adjust medication, or receive standard care. The goal is to see if this self-monitoring approach reduces painful gout flare…

This study tests a program to help people with gout get the follow-up care they need after an emergency room visit for a flare-up. The goal is to improve both short-term treatment and long-term management of gout. The study will enroll 200 adults who had a confirmed gout flare in…

This study tests two different doses of a gel medicine (Purified Cortrophin Gel) given as a single shot to adults having a sudden, painful gout flare. About 150 people will rate their pain over a week to see which dose works better and is safe. The goal is to quickly ease severe …

This study looks at how 45, 90, or 150 minutes of physical activity each week affects arthritis symptoms like pain and mobility. Researchers will track changes in walking distance and other physical functions. The goal is to find the most effective amount of exercise for people w…

This study tests whether a tablet called dapansutrile can safely reduce joint pain during an acute gout flare. About 300 adults with gout will receive either the study drug or a placebo. The main goal is to measure pain relief 72 hours after the first dose.

This study follows 450 adults with CPPD, gout, or osteoarthritis over up to 10 years. Researchers use regular ultrasounds and blood tests to see how crystal deposits in joints and blood vessels change and respond to standard treatments. The goal is to learn more about disease pro…

This study is testing whether a smartphone app called 'MinUrinsyregikt' can help people with gout manage their condition. Fifty adults with gout will use the app for three months to track their uric acid levels and symptoms. The goal is to see if the app is easy to use and if a l…

This study looks at how a new drug, ABP-671, interacts with the standard gout medication allopurinol. About 20 adults with gout who are already taking allopurinol will receive ABP-671 as well. Researchers will measure drug levels in the blood to see if there are any interactions,…